ChemicalBook > CAS DataBase List > 3-HYDROXY-5-(TRIFLUOROMETHYL)BENZOIC ACID

3-HYDROXY-5-(TRIFLUOROMETHYL)BENZOIC ACID

Product Name
3-HYDROXY-5-(TRIFLUOROMETHYL)BENZOIC ACID
CAS No.
328-69-8
Chemical Name
3-HYDROXY-5-(TRIFLUOROMETHYL)BENZOIC ACID
Synonyms
-Carboxy-5-(trifluoromethyl)phenol;3-HYDROXY-5-(TRIFLUOROMETHYL)BENZOIC ACID;Benzoic acid, 3-hydroxy-5-(trifluoromethyl)-;3-Carboxy-5-(trifluoromethyl)phenol, 3-Carboxy-5-hydroxybenzotrifluoride
CBNumber
CB7171006
Molecular Formula
C8H5F3O3
Formula Weight
206.12
MOL File
328-69-8.mol
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3-HYDROXY-5-(TRIFLUOROMETHYL)BENZOIC ACID Property

Melting point:
191-193°C
Boiling point:
333.7±42.0 °C(Predicted)
Density 
1.539±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
3.65±0.10(Predicted)
Appearance
White to off-white Solid
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Safety

Hazard Codes 
Xi
Hazard Note 
Irritant
HS Code 
2918290090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
H977538
Product name
3-Hydroxy-5-(trifluoromethyl)benzoicacid
Packaging
1g
Price
$75
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0021956
Product name
3-HYDROXY-5-(TRIFLUOROMETHYL)BENZOIC ACID
Purity
95.00%
Packaging
1G
Price
$693.92
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0021956
Product name
3-HYDROXY-5-(TRIFLUOROMETHYL)BENZOIC ACID
Purity
95.00%
Packaging
5G
Price
$1216.45
Updated
2021/12/16
Apolloscientific
Product number
PC9912
Product name
3-Hydroxy-5-(trifluoromethyl)benzoicacid
Packaging
10g
Price
$197
Updated
2021/12/16
SynQuest Laboratories
Product number
2829-3-35
Product name
3-Hydroxy-5-(trifluoromethyl)benzoic acid
Purity
97%
Packaging
5G
Price
$197
Updated
2021/12/16
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3-HYDROXY-5-(TRIFLUOROMETHYL)BENZOIC ACID Chemical Properties,Usage,Production

Synthesis

328-68-7

328-69-8

Step 2: To an aqueous suspension of 3-amino-5-trifluoromethylbenzoic acid (4.36 g, 21.3 mmol) was slowly added concentrated sulfuric acid (10.6 mL, 191 mmol) at 0 °C. The reaction mixture was stirred continuously until the solid was completely dissolved. Subsequently, an aqueous solution (40 mL) of sodium nitrite (1.47 g, 21.3 mmol) was added dropwise. The reaction mixture was continued to be stirred at 0 °C for 15 min, and then warmed up to reflux state maintained for 15 min. Upon completion of the reaction, the mixture was cooled to room temperature and extracted three times with ether. All organic layers were combined, washed with saturated brine and dried over anhydrous magnesium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to give 3-hydroxy-5-(trifluoromethyl)benzoic acid (25-2, 4.06 g) as a yellow solid.

References

[1] Patent: WO2007/64045, 2007, A1. Location in patent: Page/Page column 341-342
[2] Patent: US2018/312523, 2018, A1. Location in patent: Paragraph 1842; 1844

3-HYDROXY-5-(TRIFLUOROMETHYL)BENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3-HYDROXY-5-(TRIFLUOROMETHYL)BENZOIC ACID Suppliers

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View Lastest Price from 3-HYDROXY-5-(TRIFLUOROMETHYL)BENZOIC ACID manufacturers

Honest Joy Holdings Limited
Product
3-Hydroxy-5-(trifluoromethyl)benzoic acid 328-69-8
Price
US $0.00/KG
Min. Order
1KG
Purity
97.0%
Supply Ability
100 tons
Release date
2022-02-20

328-69-8, 3-HYDROXY-5-(TRIFLUOROMETHYL)BENZOIC ACIDRelated Search:

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  • 3-Carboxy-5-(trifluoromethyl)phenol, 3-Carboxy-5-hydroxybenzotrifluoride
  • 3-HYDROXY-5-(TRIFLUOROMETHYL)BENZOIC ACID
  • Benzoic acid, 3-hydroxy-5-(trifluoromethyl)-
  • -Carboxy-5-(trifluoromethyl)phenol
  • 328-69-8
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts