4-Trifluoromethylsalicylic acid
- Product Name
- 4-Trifluoromethylsalicylic acid
- CAS No.
- 328-90-5
- Chemical Name
- 4-Trifluoromethylsalicylic acid
- Synonyms
- 2-HYDROXY-4-(TRIFLUOROMETHYL)BENZOIC ACID;RARECHEM AL BE 1424;Desacetyl Triflusal;Triflusal Impurity 1;Triflusal EP Impurity B;Trifluoromethylsalicylicacid;p-Trifluoromethylsalicylicacid;4-(TRIFLUOROMETHY)SALICYLIC ACID;4- threefluorine Methylsalicylate;α,α,α-Trifluoro-2,4-cresotic Acid
- CBNumber
- CB6245300
- Molecular Formula
- C8H5F3O3
- Formula Weight
- 206.12
- MOL File
- 328-90-5.mol
4-Trifluoromethylsalicylic acid Property
- Melting point:
- 178 °C
- Boiling point:
- 286.4±40.0 °C(Predicted)
- Density
- 1.539±0.06 g/cm3(Predicted)
- vapor pressure
- 0.013-0.076Pa at 25℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 2.45±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C8H5F3O3/c9-8(10,11)4-1-2-5(7(13)14)6(12)3-4/h1-3,12H,(H,13,14)
- InChIKey
- XMLFPUBZFSJWCN-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(C(F)(F)F)C=C1O
- LogP
- 3.21
- CAS DataBase Reference
- 328-90-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- WGK 2
- HazardClass
- IRRITANT
- HS Code
- 29189900
- Storage Class
- 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects - Hazard Classifications
- Acute Tox. 3 Oral
Aquatic Chronic 3
Eye Dam. 1
Skin Irrit. 2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T2005010
- Product name
- Triflusal impurity B
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- 15 mg
- Price
- $127
- Updated
- 2026/04/30
- Product number
- T2005010
- Product name
- Triflusal impurity B
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- t2005010
- Price
- $150
- Updated
- 2024/03/01
- Product number
- T2064
- Product name
- 4-(Trifluoromethyl)salicylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $25
- Updated
- 2026/04/30
- Product number
- T2064
- Product name
- 4-(Trifluoromethyl)salicylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $37
- Updated
- 2026/04/30
- Product number
- D288765
- Product name
- DesacetylTriflusal
- Packaging
- 25g
- Price
- $315
- Updated
- 2021/12/16
4-Trifluoromethylsalicylic acid Chemical Properties,Usage,Production
Chemical Properties
White to off-white solid
Uses
The active metabolite of Triflusal; inhibits cardiac hypertrophy in vitro and in vivo by blocking the NF-κB signaling pathway.
Definition
ChEBI: 2-Hydroxy-4-trifluoromethyl benzoic acid is a hydroxybenzoic acid. It is functionally related to a salicylic acid.
Synthesis
455-24-3
328-90-5
General procedure for the synthesis of 2-hydroxy-4-(trifluoromethyl)benzoic acid from 4-trifluoromethylbenzoic acid: III. Pd(II)-catalyzed tert-butyl hydroxylation reaction (General Method 02): Pd(OAc)2 (11.2 mg, 0.05 mmol), 4-trifluoromethylbenzoic acid (0.5 mmol), benzoquinone (54.0 mg, 0.5 mmol), KOAc (98.0 mg, 1 mmol), and N,N-dimethylacetamide (1.5 mL) were added to a 50 mL high-pressure reactor, and the unit was equipped with a magnetic stir bar. After filling the reactor with O2 (20 atm), it was evacuated and filled again with O2 (5 atm, repeated twice). The reaction mixture was stirred at 115 °C for 15 h and subsequently cooled to room temperature. Post-reaction treatment and purification of the crude product was carried out as described previously for hydroxylation under 1 atm O2 conditions.
References
[1] Journal of the American Chemical Society, 2009, vol. 131, # 41, p. 14654 - 14655
[2] Patent: WO2011/37929, 2011, A2. Location in patent: Page/Page column 14; 19-20
4-Trifluoromethylsalicylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Trifluoromethylsalicylic acid manufacturers
- Product
- 4-Trifluoromethylsalicylic acid 328-90-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100tons
- Release date
- 2025-11-20
- Product
- 4-Trifluoromethylsalicylic acid 328-90-5
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 500KGS
- Release date
- 2021-11-08
- Product
- 4-Trifluoromethylsalicylic acid 328-90-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2025-03-10