4-Trifluoromethylsalicylic acid

Product Name: 4-Trifluoromethylsalicylic acid
CAS No.: 328-90-5
Chemical Name: 4-Trifluoromethylsalicylic acid
Synonyms: 2-HYDROXY-4-(TRIFLUOROMETHYL)BENZOIC ACID;RARECHEM AL BE 1424;Desacetyl Triflusal;Triflusal Impurity 1;Triflusal EP Impurity B;Trifluoromethylsalicylicacid;p-Trifluoromethylsalicylicacid;4-(TRIFLUOROMETHY)SALICYLIC ACID;4- threefluorine Methylsalicylate;α,α,α-Trifluoro-2,4-cresotic Acid
CBNumber: CB6245300
Molecular Formula: C8H5F3O3
Formula Weight: 206.12
MOL File: 328-90-5.mol

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4-Trifluoromethylsalicylic acid Property

Melting point:: 178 °C
Boiling point:: 286.4±40.0 °C(Predicted)
Density: 1.539±0.06 g/cm3(Predicted)
vapor pressure: 0.013-0.076Pa at 25℃
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 2.45±0.10(Predicted)
form: Solid
color: White to Off-White
InChI: InChI=1S/C8H5F3O3/c9-8(10,11)4-1-2-5(7(13)14)6(12)3-4/h1-3,12H,(H,13,14)
InChIKey: XMLFPUBZFSJWCN-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=C(C(F)(F)F)C=C1O
LogP: 3.21
CAS DataBase Reference: 328-90-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T2005010
Product name: Triflusal impurity B
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 15 mg
Price: $118
Updated: 2025/07/31

Sigma-Aldrich

Product number: T2005010
Product name: Triflusal impurity B
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: t2005010
Price: $150
Updated: 2024/03/01

TCI Chemical

Product number: T2064
Product name: 4-(Trifluoromethyl)salicylic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: T2064
Product name: 4-(Trifluoromethyl)salicylic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $46
Updated: 2025/07/31

TRC

Product number: D288765
Product name: DesacetylTriflusal
Packaging: 25g
Price: $315
Updated: 2021/12/16

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4-Trifluoromethylsalicylic acid Chemical Properties,Usage,Production

Chemical Properties

White to off-white solid

Uses

The active metabolite of Triflusal; inhibits cardiac hypertrophy in vitro and in vivo by blocking the NF-κB signaling pathway.

Definition

ChEBI: 2-Hydroxy-4-trifluoromethyl benzoic acid is a hydroxybenzoic acid. It is functionally related to a salicylic acid.

Synthesis

455-24-3

328-90-5

General procedure for the synthesis of 2-hydroxy-4-(trifluoromethyl)benzoic acid from 4-trifluoromethylbenzoic acid: III. Pd(II)-catalyzed tert-butyl hydroxylation reaction (General Method 02): Pd(OAc)2 (11.2 mg, 0.05 mmol), 4-trifluoromethylbenzoic acid (0.5 mmol), benzoquinone (54.0 mg, 0.5 mmol), KOAc (98.0 mg, 1 mmol), and N,N-dimethylacetamide (1.5 mL) were added to a 50 mL high-pressure reactor, and the unit was equipped with a magnetic stir bar. After filling the reactor with O2 (20 atm), it was evacuated and filled again with O2 (5 atm, repeated twice). The reaction mixture was stirred at 115 °C for 15 h and subsequently cooled to room temperature. Post-reaction treatment and purification of the crude product was carried out as described previously for hydroxylation under 1 atm O2 conditions.

References

[1] Journal of the American Chemical Society, 2009, vol. 131, # 41, p. 14654 - 14655
[2] Patent: WO2011/37929, 2011, A2. Location in patent: Page/Page column 14; 19-20

4-Trifluoromethylsalicylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Trifluoromethylsalicylic acid Suppliers

Canada 1 China 332 Europe 3 Germany 4 India 9 Italy 1 Japan 3 Slovakia 1 South Korea 1 Ukraine 1 United Kingdom 13 United States 28 Global 397

Inner Mongolia Yida Chemical Technology Co., Ltd.

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TCI (Shanghai) Development Co., Ltd.

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Beijing dtftchem Technology Co., Ltd.

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View Lastest Price from 4-Trifluoromethylsalicylic acid manufacturers

Shandong Vital Biotechnology Co., Ltd.

Product: 4-Trifluoromethylsalicylic acid 328-90-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100tons
Release date: 2025-11-20

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Trifluoromethylsalicylic acid 328-90-5
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min
Supply Ability: 500KGS
Release date: 2021-11-08

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Trifluoromethylsalicylic acid 328-90-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-10

328-90-5, 4-Trifluoromethylsalicylic acidRelated Search:

4'-(Trifluoromethyl)acetophenone Trifluoromethanesulfonic acid 2-Hydroxy-6-methylbenzoic acid CHLOROPHOSPHONAZO III 3-Aminobenzotrifluoride 2-Methylbenzotrifluoride 3-(Trifluoromethyl)benzoic acid Salicylic acid 4-(Trifluoromethyl)cinnamic acid (Trifluoromethyl)trimethylsilane 4-Methylsalicylic acid 3-Hydroxybenzoic acid 2'-Hydroxy-3-phenylpropiophenone 2-(Trifluoromethyl)benzoic acid 2-(Trifluoromethyl)benzyl chloride 5-Methylsalicylic acid 4-(Trifluoromethyl)benzoic acid 3-(Trifluoromethyl)benzaldehyde

4-(Trifluoromethyl)salicylic acid, 2-Carboxy-5-(trifluoromethyl)phenol, 4-Carboxy-3-hydroxybenzotrifluoride

4-(TrifluoroMethyl)salicylic acid, water ≤0.3%

α,α,α-Trifluoro-2,4-cresotic Acid

4- threefluorine Methylsalicylate

4-(TrifluoroMethyl)benzoic Acid, 97+%

p-Trifluoromethylsalicylicacid

4-(TRIFLUOROMETHYL)SALICYLIC ACID

2-HYDROXY-4-(TRIFLUOROMETHYL)BENZOIC ACID

4-Trifluoro Methyl Salicylic Acid (>=99%)

RARECHEM AL BE 1424

4-(TRIFLUOROMETHYL)-2-HYDROXYBENZOIC ACID

4-(TRIFLUOROMETHY)SALICYLIC ACID

4-TrifluoromethylSalicylicAcid>99.0%

4-Trifluoromethy Salicylic Acid >99.0%

Trifluoromethylsalicylicacid

2-HYDROXY-4-TRIFLUOROMETHYLBENZOIC ACID, 4-TRIFLUORO METHYL SALICYLIC ACID

BENZOIC ACID, 2-HYDROXY-4-(TRIFLUOROMETHYL)-

Desacetyl Triflusal

4-(Trifluoromethyl)salicylic acid, 99%, water ≤0.3%

2-Hydroxy-4-(trifluoromethyl)benzoic acid 98%

Triflusal EP Impurity B

2-Hydroxy-4-(trifluoromethyl)benzoi

Triflusal Impurity 2 (Triflusal EP Impurity B)

4-TRIFLUOROMETHYL SALICYLIC ACID/328-90-5

TIANFUCHEM--328-90-5--4-Trifluoromethylsalicylic acid factory price

Triflusal Impurity 1

328-90-5

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Metabolites & Impurities

Pharmaceuticals

Aromatics

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

328-90-5