ChemicalBook > CAS DataBase List > 3-Bromopropionic acid

3-Bromopropionic acid

Product Name
3-Bromopropionic acid
CAS No.
590-92-1
Chemical Name
3-Bromopropionic acid
Synonyms
3-Bromopropanoic acid;Valine Impurity 30;3-Bromoprpionicacid;-Bromopropionicacid;RARECHEM AL BO 0160;3-bromopropanoicacid;3-bromo-propanoicaci;3-bromo-propionicaci;3-BROMPROPIONIC ACID;3-bromo-Propanoicacid
CBNumber
CB7177280
Molecular Formula
C3H5BrO2
Formula Weight
152.97
MOL File
590-92-1.mol
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3-Bromopropionic acid Property

Melting point:
58-62 °C(lit.)
Boiling point:
140-142 °C (45 mmHg)
Density 
1.48 g/mL at 25 °C(lit.)
refractive index 
1.4753 (estimate)
Flash point:
150 °F
storage temp. 
2-8°C
solubility 
H2O: 0.1 g/mL, clear
form 
Crystals or Crystalline Powder
pka
4.00(at 25℃)
color 
White to slightly yellow
Water Solubility 
0.1 g/mL
Merck 
14,1433
BRN 
1071333
Dielectric constant
11.0（20℃）
CAS DataBase Reference
590-92-1(CAS DataBase Reference)
NIST Chemistry Reference
Propanoic acid, 3-bromo-(590-92-1)
EPA Substance Registry System
Propanoic acid, 3-bromo- (590-92-1)
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Safety

Hazard Codes 
F,C
Risk Statements 
11-34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
RTECS 
UE7875000
Hazard Note 
Corrosive/Highly Flammable
TSCA 
Yes
HazardClass 
4.1
PackingGroup 
III
HS Code 
29159080
Hazardous Substances Data
590-92-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
101281
Product name
3-Bromopropionic acid
Purity
97%
Packaging
100g
Price
$73.2
Updated
2024/03/01
TCI Chemical
Product number
B0645
Product name
3-Bromopropionic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$27
Updated
2024/03/01
TCI Chemical
Product number
B0645
Product name
3-Bromopropionic Acid
Purity
>98.0%(GC)(T)
Packaging
100g
Price
$52
Updated
2024/03/01
Alfa Aesar
Product number
A11573
Product name
3-Bromopropionic acid, 97%
Packaging
25g
Price
$24.65
Updated
2024/03/01
Alfa Aesar
Product number
A11573
Product name
3-Bromopropionic acid, 97%
Packaging
100g
Price
$43.6
Updated
2024/03/01
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3-Bromopropionic acid Chemical Properties,Usage,Production

Chemical Properties

white to pale yellow or orange crystalline. soluble in water, alcohol, ether, chloroform, benzene. Hydrolysis in alkaline solution generates hydroxypropionic acid. Corrosive. for organic synthesis.

Uses

3-Bromopropionic acid used as quaternization agent in amperometric biosensors.

Application

3-Bromopropionic acid is a widely used chemical intermediate. It can be used as a starting material to synthesize derivatives such as esters, acid halides and amides; the active group bromine can undergo a series of reactions, and is mainly used in the fields of pesticides and medicines. Such as the pesticides diflufenacil, furalax and so on.

Preparation

3-Bromopropionic acid is prepared by reacting acrylonitrile with hydrogen bromide to obtain bromopropionitrile and then hydrolyzing it. Add acrylonitrile to boiling hydrobromic acid, reflux at 130°C for 6 hours, extract the solid obtained by filtration with ethanol, and obtain the crude product after recovering ethanol by distillation under reduced pressure. By heating 2-cyanoethanol and 40% hydrobromic acid to reflux for 2h, 3-bromopropionic acid can also be produced with a yield of over 80%.

Synthesis Reference(s)

Journal of the American Chemical Society, 71, p. 2807, 1949 DOI: 10.1021/ja01176a061
Organic Syntheses, Coll. Vol. 1, p. 131, 1941

Safety Profile

Moderately toxic by intraperitoneal route. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Br-. See also BROMIDES.

Purification Methods

The acid crystallises as plates from CCl4. It is soluble in organic solvents and H2O. Its methyl ester has b 65o/18mm and 80o/27mm. The S-benzylisothiouronium salt has m 136o. [Kendall & McKenzie Org Synth Coll Vol I 131 1941, Beilstein 2 IV 764.]

3-Bromopropionic acid Preparation Products And Raw materials

Raw materials

3-Hydroxypropionitrile

Preparation Products

2-Oxetanone 4H-AMINO-6-BROMO-2,3-DIHYDROTHIOCHROMEN-1,1-DIOXIDE 6-bromo-2,3-dihydrothiochromen-1,1-dioxide-4-one 3-(4-OXO-6-PHENYL-1,4-DIHYDRO-PYRIMIDIN-2-YLSULFANYL)-PROPIONIC ACID 4-Chromanone 4-Hydroxy-6-bromo-2,3-dihydrothiochromen-1,1-dioxide Ethyl 3-bromopropionate 6-bromo-2,3-dihydrothiochromen-4-one
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3-Bromopropionic acid Suppliers

Americas 1 Belgium 1 Canada 2 China 198 Europe 3 France 2 Germany 6 India 23 Israel 1 Japan 9 Russia 1 Slovakia 1 Switzerland 2 The Netherlands 1 Ukraine 2 United Kingdom 17 United States 39 Global 309
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View Lastest Price from 3-Bromopropionic acid manufacturers

Hebei Duling International Trade Co. LTD
Product
3-Bromopropionic acid 590-92-1
Price
US $20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 Ton
Release date
2023-03-15
Hebei Mojin Biotechnology Co., Ltd
Product
3-Bromopropionic acid 590-92-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-07-28
Career Henan Chemical Co
Product
3-Bromopropionic acid 590-92-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2019-08-07

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  • RARECHEM AL BO 0160
  • 3-Bromopropionic Acid (CAS No. : 590-92-1)
  • 3-Bromopropionic Acid &gt
  • Valine Impurity 30
  • 590-92-1
  • CH2BrCH2COOH
  • BrCH2CH2CO2H
  • C3H5O2BR
  • CARBOXYLIC ACID
  • Organic Building Blocks
  • 蠅-Functional Alkanols, Carboxylic Acids, Amines & Halides
  • 蠅-Bromocarboxylic Acids
  • C1 to C5
  • Carbonyl Compounds
  • Carboxylic Acids
  • Building Blocks
  • Aromatic Propionic Acids
  • Organic acids
  • Pyridines derivates
  • omega-Bromocarboxylic Acids
  • omega-Functional Alkanols, Carboxylic Acids, Amines & Halides
  • C1 to C5
  • Carbonyl Compounds
  • Carboxylic Acids