ChemicalBook > CAS DataBase List > H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH

H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH

Product Name
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
CAS No.
117399-93-6
Chemical Name
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
Synonyms
et-3;EDN3;HSCR4;human,rat;ET-3, HUMAN;ENDOTHELIN-3;Rat endothelin-3;ET-3 (HUMAN, RAT);Endothelin 3【rat】;Human endothelin-3
CBNumber
CB7181630
Molecular Formula
C121H168N26O33S4
Formula Weight
2643.04
MOL File
117399-93-6.mol
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H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Property

Density 
1.285±0.06 g/cm3(Predicted)
storage temp. 
−20°C
form 
powder
color 
white
Water Solubility 
Soluble to 1 mg/ml in water
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Safety

Safety Statements 
22
WGK Germany 
3
F 
3-10
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E9137
Product name
Endothelin 3 human, rat
Purity
≥97%(HPLC),powder
Packaging
10μg
Price
$127
Updated
2024/03/01
Sigma-Aldrich
Product number
E9137
Product name
Endothelin 3 human, rat
Purity
≥97%(HPLC),powder
Packaging
50μg
Price
$226.2
Updated
2024/03/01
Sigma-Aldrich
Product number
E9137
Product name
Endothelin 3 human, rat
Purity
≥97%(HPLC),powder
Packaging
0.1mg
Price
$679
Updated
2024/03/01
Sigma-Aldrich
Product number
05-23-3801
Product name
Endothelin 3, Human and Rat
Purity
Attenuates thrombin-evoked aggregation of human platelets.
Packaging
0.5MG
Price
$509
Updated
2024/03/01
Sigma-Aldrich
Product number
05-23-3801
Product name
Endothelin 3, Human and Rat - CAS 117399-93-6 - Calbiochem
Purity
Attenuates thrombin-evoked aggregation of human platelets.
Packaging
.5mg
Price
$487
Updated
2023/01/07
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H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Chemical Properties,Usage,Production

Uses

Endothelin 3 human, rat has been used for culturing neural tube explant culture, and the pharmacological study of endothelin receptors.

General Description

Endothelin 3 (ET3) belongs to endothelin peptide family, which includes three members, ET-1, -2 and -3. These are 21-amino acid peptides, which are synthesized as precursors. They are converted to biologically active peptides, after being cleaved by proteases. There are two endothelin receptors called ETRA and ETRB, and ET3 binds to ETRB. It is localized to human intestine and colon.

Biochem/physiol Actions

Endothelin 3 (ET3) is a vasoconstrictor that acts in a paracrine and autocrine manner, and in intestinal lamina propria causes the degranulation of mast cells. It results in the release of ions from intestinal epithelial cells. In acute and chronic intestinal inflammation, it is overexpressed. It is also up-regulated in colon carcinoma, where it supports cell proliferation and survival. It might be involved in colon homeostasis, and is essential for the survival and proliferation of goblet cells. In mice, it is essential for the development of pigment cells derived from neural crest (NC). Its expression is de-regulated in metastatic melanoma.

storage

Store at -20°C

H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH Suppliers

China 89 Europe 3 Germany 2 Switzerland 1 United Kingdom 2 United States 14 Global 111
MOLEKULA Ltd.
Tel
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Fax
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Email
kevinbanks@molekula.com
Country
United Kingdom
ProdList
6140
Advantage
66
Tocris Bioscience
Tel
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Fax
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Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
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77
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View Lastest Price from H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH manufacturers

Career Henan Chemical Co
Product
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH 117399-93-6
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-12
Career Henan Chemical Co
Product
H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH 117399-93-6
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-12

117399-93-6, H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OHRelated Search:

IRL-1038 Endothelin-1 (human, porcine) H-CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH BIG ET-1 (1-38) (HUMAN) ENDOTHELIN (16-21) GLYCYL-L-TRYPTOPHAN H-VAL-TRP-OH H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH N-ACETYL-L-HISTIDINE METHYL AMIDE H-ILE-ALA-OH GLYCYL-DL-TRYPTOPHAN H-LEU-BETA-ALA-OH H-GLY-GLY-TRP-OH H-VAL-GLY-GLY-OH L-ALANYL-L-TRYPTOPHAN H-ILE-TRP-OH AC-PHE-TYR-NH2 H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH

  • ENDOTHELIN-III, HUMAN, RAT
  • ENDOTHELIN-3
  • ENDOTHELIN-3, HUMAN
  • ENDOTHELIN 3, HUMAN AND RAT
  • ENDOTHELIN-3 (HUMAN, MOUSE, RABBIT, RAT)
  • ENDOTHELIN-3 (HUMAN) (PORCINE, RAT, RABBIT)
  • ENDOTHELIN 3 HUMAN, RAT
  • ENDOTHELIN-3 (HUMAN, RAT, PIG)
  • ENDOTHELIN-3 (HUMAN, RAT, PORCINE, RABBIT)
  • CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP
  • CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP HUMAN, RAT, PORCINE, RABBIT
  • CTCFTYKDKECVYYCHLDIIW
  • CTCFTYKDKECVYYCHLDIIW (DISULFIDE BRIDGE: 1-15 AND 3-11)
  • H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH
  • H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH (DISULFIDE BRIDGE: 1-15 AND 3-11)
  • ET-3, HUMAN
  • ET-3, HUMAN AND RAT
  • ET-3 (HUMAN, MOUSE, RABBIT, RAT)
  • ET-3 (HUMAN, RAT)
  • ET-3 (HUMAN, RAT, PIG)
  • ENDOTHELIN 3, HUMAN, RAT, 50 UG*
  • human,rat
  • et-3
  • M.W. 2643.04 C121H168N26O33S4
  • Endothelin 3【canine】
  • Endothelin 3【rabbit】
  • Endothelin 3【rat】
  • CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR- TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP(DISULFIDE BRIDGE:CYS1-CYS15, CYS3-CYS11)
  • CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP: CTCFTYKDKECVYYCHLDIIW DISULFIDE BRIDGES CYS1-CYS15, CYS3-CYS11
  • Endothelin-3 (huMan, Mouse, rabbit, rat) ET-3 (huMan, Mouse, rabbit, rat)
  • Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridges Cys1-Cys15 and Cys3-Cys11)
  • Endothelin 3 huMan, ratEndothelin
  • Endothelin 3 (huMan)(9CI)
  • Anti-EDN3 antibody produced in rabbit
  • EDN3
  • HSCR4
  • ANTI-EDN3 (C-TERM) antibody produced in rabbit
  • 19: PN: WO2007112069 SEQID: 10 claimed protein
  • 33,34,49,50-Tetrathia-2,5,8,11,14,17,20,23,26,29,37,40,43,46-tetradecaazabicyclo[23.22.4]henpentacontane, cyclic peptide deriv.
  • Endothelin 3 (mouse intestine)
  • Human endothelin-3
  • Rat endothelin-3
  • Endothelin 3, human, rat, ≥97% (HPLC), powder
  • Endothelin 3, Human and Rat - CAS 117399-93-6 - Calbiochem
  • Endothelin 3 (Rat,Human)
  • L-Tryptophan, L-cysteinyl-L-threonyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-tyrosyl-L-lysyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-tyrosyl-L-cysteinyl-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-, cyclic (1→15),(3→11)-bis(disulfide)
  • H-CYS-THR-CYS-PHE-THR-TYR-LYS-ASP-LYS-GLU-CYS-VAL-TYR-TYR-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH USP/EP/BP
  • Endothelin 3 human, rat (TFA)
  • 117399-93-6
  • C121H168N26O33S4
  • Agonist
  • BioChemical
  • Amino Acids and Peptides
  • Biochemicals and Reagents
  • Peptides
  • Endothelins
  • Peptide
  • Endothelin receptor