Trolox

Product Name: Trolox
CAS No.: 53188-07-1
Chemical Name: Trolox
Synonyms: TROLOX;TROLOX;troloxc;TROLOX(R);trolox tm;TROLOXTM C;Trolox(R),97%;Trolox, 97% 1GR;Trolox, 97% 5GR;Trolox Standard
CBNumber: CB7188583
Molecular Formula: C14H18O4
Formula Weight: 250.29
MOL File: 53188-07-1.mol

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Trolox Property

Melting point:: 187-189 °C (lit.)
Boiling point:: 313.42°C (rough estimate)
Density: 1.0616 (rough estimate)
refractive index: 1.4970 (estimate)
storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). Also soluble in Water at alkalinepH.
pka: 3.35±0.20(Predicted)
form: Crystalline Powder
color: White to faintly beige
BRN: 1384051
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChI: InChI=1S/C14H18O4/c1-7-8(2)12-10(9(3)11(7)15)5-6-14(4,18-12)13(16)17/h15H,5-6H2,1-4H3,(H,16,17)
InChIKey: GLEVLJDDWXEYCO-UHFFFAOYSA-N
SMILES: C1(C)(C(O)=O)OC2=C(C)C(C)=C(O)C(C)=C2CC1
CAS DataBase Reference: 53188-07-1(CAS DataBase Reference)
EPA Substance Registry System: 3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid (53188-07-1)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 2
RTECS: DJ2273000
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 238813
Product name: (±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $78.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 238813
Product name: (±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid
Purity: 97%
Packaging: 5g
Price: $194
Updated: 2024/03/01

TCI Chemical

Product number: H0726
Product name: 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $67
Updated: 2024/03/01

TCI Chemical

Product number: H0726
Product name: 6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 10011659
Product name: Trolox
Purity: ≥98%
Packaging: 250mg
Price: $32
Updated: 2024/03/01

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Trolox Chemical Properties,Usage,Production

Description

Trolox (53188-07-1) is a water soluble derivative of vitamin E. Displays antioxidant and radical scavenging activities.1 Prevents lipid peroxidation induced by CYP2E1 in Hep G2 cells.2 Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes.3

Chemical Properties

white to fainly beige crystalline powder

Uses

An antioxidant derived from water-soluble vitamin E

Uses

Trolox is a Vitamin E analog that also maintains the antioxidant capabilities which Vitamin E shows. Neuroprotective product.

Definition

ChEBI: A chromanol that is 6-hydroxychromane which is substituted by a carboxy group at position 2 and by methyl groups at positions 2, 5, 7, and 8. A cell-permeable, water-soluble analogue of vitamin E, it is used as a standard for measuring the antioxidant capa ity of complex mixtures.

Application

Trolox is a cell-permeable, water-soluble derivative of vitamin E with potent antioxidant properties. lt is commonly used as a standard or positive control in antioxidant assays. In addition, trolox is used to assessthe role of oxidative injury in processes like neuronal cell death and aging. It is effective as adjunctivetherapy in the treatment of certain cancers.

General Description

(±)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (Trolox) exhibits radical scavenging and antioxidant activities.

Mechanism of action

Trolox can protect against oxidative stress, genotoxicity and inflammation induced by CS through ROS scavenging mechanism, and serve as a potential antioxidant prevention strategy against oxidative injury of ATII cells in CS-related lung diseases.

storage

Store at +4°C

References

1) Massey et al. (1990), Free radical damage in neonatal rat cardiac myocyte cultures: effects of alpha-tocopherol, Trolox and phytol; Free Radic. Biol. Med., 8 449 2) Chen et al. (1998), Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells; Mol. Pharmacol., 53 638 3) Brookes et al. (1996), Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes; Arch. Biochem. Biophys., 333 482

Trolox Preparation Products And Raw materials

Raw materials

Preparation Products

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Trolox Suppliers

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View Lastest Price from Trolox manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID 53188-07-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-29

Hebei Mojin Biotechnology Co., Ltd

Product: Trolox 53188-07-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-10-25

Zhuozhou Wenxi import and Export Co., Ltd

Product: (+/-)-6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid 97% 53188-07-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

53188-07-1, Trolox Related Search:

tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate Poly(ethylene glycol) dimethacrylate DICYCLOPENTANYL METHACRYLATE 2-(Perfluorohexyl)ethyl methacrylate Trimethylolpropane trimethacrylate Butyl methacrylate Methyl propiolate Trimethylolpropane triacrylate 6-Hydroxypicolinic acid Guaiazulene Trolox (S)-(-)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID (R)-6-METHOXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID (S)-6-METHOXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID (R)-(+)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID Succinimidyl (2R)-6-(Tetrahydro-2H-pyran-2-yloxy)-2,5,7,8-tetramethylchroman-2-carboxylate 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID 6-METHOXY-2,5,7,8-TETRAMETHYL-CHROMAN-2-CARBOXYLIC ACID METHYL ESTER

3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2h-1-benzopyran-2-carboxylicaci

troloxc

6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID

(+/-)-6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID

TROLOX

TROLOX(R)

TROLOXTM C

TIMTEC-BB SBB005933

trolox tm

(+/-)-6-HYDROXY-2,5,7,8-TETRAMETHYL-CHRO M.-2-CARBOXYL.AC

rac-2,5,7,8-Tetramethyl-6-hydroxychroman-2α*-carboxylic acid

3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid

Trolox(R),97%

Trolox, 97% 1GR

Trolox, 97% 5GR

6-hydroxy-2,5,7,8-tetraMethychroMan-2-caboxylic acid (Trolox)

(+/-)-6-Hydroxy-2,5,7,8-tetraMethylchroMane-2-carboxylic acid 97%

6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylicAcid&gt

Trolox Standard

2H-1-Benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-

6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID ISO 9001：2015 REACH

53188-07-1 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID

6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromene-2-carboxylic acid

TROLOX

Ferroptosis,Inhibitor,Apoptosis,Reactive Oxygen Species,inhibit,Trolox

53188-07-1

3188-07-1

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