ChemicalBook > CAS DataBase List > Homovanillic acid

Homovanillic acid

Product Name
Homovanillic acid
CAS No.
306-08-1
Chemical Name
Homovanillic acid
Synonyms
HVA;Homovanilic acid;4-HYDROXY-3-METHOXYPHENYLACETIC ACID;4-Hydroxy-3-methoxybenzeneacetic acid;Benzeneacetic acid, 4-hydroxy-3-methoxy-;JACS-306-08-1;homovanillicaci;Vanilacetic acid;HOMOVANIUIC ACID;Vanillacetic Acid
CBNumber
CB7198081
Molecular Formula
C9H10O4
Formula Weight
182.17
MOL File
306-08-1.mol
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Homovanillic acid Property

Melting point:
142-145 °C(lit.)
Boiling point:
235.56°C (rough estimate)
Density 
1.1634 (rough estimate)
refractive index 
1.4209 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
pka
4.39±0.10(Predicted)
form 
Crystalline Powder
color 
White to beige
Water Solubility 
soluble
Merck 
14,4740
BRN 
2213447
Stability:
Hygroscopic
LogP
0.330
CAS DataBase Reference
306-08-1(CAS DataBase Reference)
NIST Chemistry Reference
Benzeneacetic acid, 4-hydroxy-3-methoxy-(306-08-1)
EPA Substance Registry System
Homovanillic acid (306-08-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
10-23
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29189900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H1252
Product name
Homovanillic acid
Purity
Fluorimetric reagent
Packaging
1g
Price
$92.7
Updated
2024/03/01
Sigma-Aldrich
Product number
69673
Product name
Homovanillic acid
Purity
analytical standard
Packaging
25mg
Price
$71.4
Updated
2024/03/01
TCI Chemical
Product number
H0339
Product name
4-Hydroxy-3-methoxyphenylacetic Acid
Purity
>98.0%(T)
Packaging
1g
Price
$42
Updated
2024/03/01
TCI Chemical
Product number
H0339
Product name
4-Hydroxy-3-methoxyphenylacetic Acid
Purity
>98.0%(T)
Packaging
5g
Price
$141
Updated
2024/03/01
Alfa Aesar
Product number
A12441
Product name
Homovanillic acid, 98+%
Packaging
1g
Price
$72.4
Updated
2024/03/01
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Homovanillic acid Chemical Properties,Usage,Production

Description

Homovanillic acid (HVA) is a dopamine metabolite. It is formed via deamination of dopamine by monoamine oxidase (MAO) to produce 3,4-dihydroxyphenylacetic acid (DOPAC; ) followed by DOPAC metabolism by catechol-O-methyltransferase (COMT). HVA undergoes hydrogen peroxide-dependent oxidation in the presence of horseradish peroxidase to form a fluorescent dimer that displays excitation/emission maxima of 312/420 nm, respectively. It has been used to quantify hydrogen peroxide production in macrophages and neutrophils.

Chemical Properties

white to beige crystalline powder

Uses

Fluorimetric reagent and major catecholamine metaboliteHomovanillic acid is used as a reagent in the determination of oxidative enzymes. It is associated with dopamine levels in the brain. Its presence supports a diagnosis of neuroblastoma and malignant pheochromocytoma.

Uses

A neuroendocrine tumor marker. Dihydroxyphenylacetic Acid (DOPAC) metabolite.

Definition

ChEBI: A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.

Biological Activity

Fluorimetric reagent and major catecholamine metabolite. Used for fluorimetric determination of oxidative enzymes including glucose oxidase.

storage

+4°C

Homovanillic acid Preparation Products And Raw materials

Raw materials

Guaiacol Palladium Sodium hydroxide Glyoxylic acid Sulfuric acid

Preparation Products

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Homovanillic acid Suppliers

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View Lastest Price from Homovanillic acid manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
Chromic sulfate 306-08-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-10-16
Shanghai Standard Technology Co., Ltd.
Product
Homovanillic acid 306-08-1
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-11-28
Zhuozhou Wenxi import and Export Co., Ltd
Product
Homovanillic acid 306-08-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

306-08-1, Homovanillic acidRelated Search:

N,N'-1,3-Phenylene bismaleimide Citric acid Folic acid CHLOROPHOSPHONAZO III 2-Hydroxyphenylacetic acid Oxalic acid dihydrate Stearic acid Vanillic acid DL-Mandelic acid 4-Hydroxyphenylacetic acid 4-Methoxyphenylacetic acid Ethyl 2-(Chlorosulfonyl)acetate Ascoric Acid Acetic anhydride Testosterone phenylacetate 3,4,5-Trimethoxyphenylacetic acid HOMOVANILLIC ACID ETHYL ESTER,Homovanillic acid ethyl DL-4-HYDROXY-3-METHOXYMANDELIC ACID

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