2-Fluoroethyl 4-methylbenzenesulfonate

Product Name: 2-Fluoroethyl 4-methylbenzenesulfonate
CAS No.: 383-50-6
Chemical Name: 2-Fluoroethyl 4-methylbenzenesulfonate
Synonyms: Fluoroethylp-tosylate;2-FLUOROETHYL TOSYLATE;2-Fluoroethanol tosylate;L-TRYPTOPHAN/D-TRYPTOPHAN;2-Fluoroethyl 4-methylben;FLUOROETHYL 4-TOLUENESULFONATE;Fluoroethyl p-toluenesulfonate;2-Fluoro-ethanol 1-( tosylate);2-Fluoroethyl p-Toluenesulfonate;2-fluoroethyl 4-methylbenzenesulfonate
CBNumber: CB7206867
Molecular Formula: C9H11FO3S
Formula Weight: 218.25
MOL File: 383-50-6.mol

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2-Fluoroethyl 4-methylbenzenesulfonate Property

Boiling point:: 140°C/1mmHg(lit.)
Density: 1.290 g/cm3
refractive index: 1.5060 to 1.5100
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Oil
color: Clear Colourless to Pale Brown
InChI: InChI=1S/C9H11FO3S/c1-8-2-4-9(5-3-8)14(11,12)13-7-6-10/h2-5H,6-7H2,1H3
InChIKey: XNRDLSNSMTUXBV-UHFFFAOYSA-N
SMILES: C(OS(C1=CC=C(C)C=C1)(=O)=O)CF
CAS DataBase Reference: 383-50-6(CAS DataBase Reference)

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Safety

HS Code: 2930909899

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: F1056
Product name: 2-Fluoroethyl p-Toluenesulfonate
Purity: >98.0%(GC)
Packaging: 1g
Price: $181
Updated: 2025/07/31

TCI Chemical

Product number: F1056
Product name: 2-Fluoroethyl p-Toluenesulfonate
Purity: >98.0%(GC)
Packaging: 5g
Price: $451
Updated: 2025/07/31

TRC

Product number: F591735
Product name: 2-FluoroethylTosylate
Packaging: 250mg
Price: $45
Updated: 2021/12/16

TRC

Product number: F591735
Product name: 2-FluoroethylTosylate
Packaging: 1g
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: J94890
Product name: 2-Fluoroethyl4-methylbenzenesulfonate
Packaging: 1g
Price: $49
Updated: 2021/12/16

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2-Fluoroethyl 4-methylbenzenesulfonate Chemical Properties,Usage,Production

Uses

2-Fluoroethyl Tosylate is an intermediate used in the preparation and pre-clinical evaluation of new class of high-affinity 18F-labeled PSMA ligands for detection of prostate cancer by positron emission tomography (PET) imaging.

Synthesis

371-62-0

98-59-9

383-50-6

2-Fluoroethanol (1.00 mL, 16.9 mmol), p-toluenesulfonyl chloride (3.85 g, 20.2 mmol), N-methylmorpholine (9.30 mL, 84.5 mmol), and dichloromethane (50 mL) were added to the reaction vessel, and the reaction was stirred for 17 hours at room temperature. After completion of the reaction, water was added to the reaction system and extracted with ethyl acetate three times to combine the organic layers. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. After concentration under reduced pressure, the residue was purified by fast silica gel column chromatography (eluent: ethyl acetate/hexane=19:81→40:60) to afford fluoroethyl p-toluenesulfonate (3.79 g, 17.2 mmol, yield >100%) as a pale yellow liquid.1H NMR (600 MHz, CDCl3): δ 7.81 (d, J=8.4 Hz, 2H), δ 7.36 (d, J=8.4 Hz, 2H), 4.63-4.60 (m, 1H), 4.55-4.52 (m, 1H), 4.31-4.27 (m, 1H), 4.26-4.23 (m, 1H), 2.46 (s, 3H). lRMS (EI) Calculated value (C9H11F3O): 218.0, measured value: 218.0.

References

[1] Patent: US2018/30074, 2018, A1. Location in patent: Paragraph 0188-0191
[2] Journal of Labelled Compounds and Radiopharmaceuticals, 2008, vol. 51, # 7, p. 286 - 292
[3] Patent: US2013/177501, 2013, A1. Location in patent: Paragraph 0168
[4] Patent: US9168317, 2015, B2. Location in patent: Page/Page column 25; 26
[5] Patent: US9314541, 2016, B2. Location in patent: Page/Page column 26

2-Fluoroethyl 4-methylbenzenesulfonate Preparation Products And Raw materials

Raw materials

Tosyl chloride 2-Fluoroethanol

Preparation Products

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2-Fluoroethyl 4-methylbenzenesulfonate Suppliers

Americas 1 Australia 1 Belgium 1 Canada 1 China 99 Europe 2 France 2 Germany 5 India 3 Japan 1 South Korea 1 Switzerland 1 United Kingdom 6 United States 23 Global 147

Quzhou Fluorio Pharmtech Co.,Ltd.

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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Shanghai Sunway Pharmaceutical Technology Co., Ltd

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Hangzhou Yuhao Chemical Technology Co., Ltd

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Nanjing Norris-Pharm Technology Co., Ltd

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View Lastest Price from 2-Fluoroethyl 4-methylbenzenesulfonate manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Fluoroethyl 4-methylbenzenesulfonate 383-50-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-09

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Fluoroethyl 4-methylbenzenesulfonate 383-50-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20t
Release date: 2024-06-25

Honest Joy Holdings Limited

Product: 2-Fluoroethyl 4-methylbenzenesulfonate 383-50-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.5%
Supply Ability: 100 tons
Release date: 2022-02-21

383-50-6, 2-Fluoroethyl 4-methylbenzenesulfonateRelated Search:

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Fluoroethylp-tosylate

2-Fluoro-(4-methylbenzenesulfonate)ethanol

FLUOROETHYL 4-TOLUENESULFONATE

2-FLUOROETHYL TOSYLATE

L-TRYPTOPHAN/D-TRYPTOPHAN

2-fluoroethyl 4-methylbenzenesulfonate

Fluoroethyl p-toluenesulfonate

4-Methylbenzenesulfonic acid 2-fluoro-ethyl ester

2-fluoroethyl 4-Methylbenzene-1-sulfonate

Toluene-4-sulfonic acid 2-fluoroethyl ester

2-Fluoroethyl <i>p</i>-Toluenesulfonate

2-Fluoroethyl p-Toluenesulfonate

Ethanol, 2-fluoro-, 1-(4-methylbenzenesulfonate)

p-Toluenesulfonic Acid 2-Fluoroethyl Ester

2-Fluoroethyl 4-methylben

2-fluoro-Ethanol 1-(4-methylbenzenesulfonate)

2-Fluoroethanol tosylate

2-Fluoro-ethanol 1-( tosylate)

383-50-6

C9H12FO3S

C9H11FO3S