2-Fluoroethyl 4-methylbenzenesulfonate
- Product Name
- 2-Fluoroethyl 4-methylbenzenesulfonate
- CAS No.
- 383-50-6
- Chemical Name
- 2-Fluoroethyl 4-methylbenzenesulfonate
- Synonyms
- Fluoroethylp-tosylate;2-FLUOROETHYL TOSYLATE;2-Fluoroethanol tosylate;L-TRYPTOPHAN/D-TRYPTOPHAN;2-Fluoroethyl 4-methylben;FLUOROETHYL 4-TOLUENESULFONATE;Fluoroethyl p-toluenesulfonate;2-Fluoro-ethanol 1-( tosylate);2-Fluoroethyl p-Toluenesulfonate;2-fluoroethyl 4-methylbenzenesulfonate
- CBNumber
- CB7206867
- Molecular Formula
- C9H11FO3S
- Formula Weight
- 218.25
- MOL File
- 383-50-6.mol
2-Fluoroethyl 4-methylbenzenesulfonate Property
- Boiling point:
- 140°C/1mmHg(lit.)
- Density
- 1.290 g/cm3
- refractive index
- 1.5060 to 1.5100
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Oil
- color
- Clear Colourless to Pale Brown
- InChI
- InChI=1S/C9H11FO3S/c1-8-2-4-9(5-3-8)14(11,12)13-7-6-10/h2-5H,6-7H2,1H3
- InChIKey
- XNRDLSNSMTUXBV-UHFFFAOYSA-N
- SMILES
- C(OS(C1=CC=C(C)C=C1)(=O)=O)CF
- CAS DataBase Reference
- 383-50-6(CAS DataBase Reference)
Safety
- HS Code
- 2930909899
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- F1056
- Product name
- 2-Fluoroethyl p-Toluenesulfonate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $181
- Updated
- 2025/07/31
- Product number
- F1056
- Product name
- 2-Fluoroethyl p-Toluenesulfonate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $451
- Updated
- 2025/07/31
- Product number
- F591735
- Product name
- 2-FluoroethylTosylate
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- F591735
- Product name
- 2-FluoroethylTosylate
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- J94890
- Product name
- 2-Fluoroethyl4-methylbenzenesulfonate
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
2-Fluoroethyl 4-methylbenzenesulfonate Chemical Properties,Usage,Production
Uses
2-Fluoroethyl Tosylate is an intermediate used in the preparation and pre-clinical evaluation of new class of high-affinity 18F-labeled PSMA ligands for detection of prostate cancer by positron emission tomography (PET) imaging.
Synthesis
371-62-0
98-59-9
383-50-6
2-Fluoroethanol (1.00 mL, 16.9 mmol), p-toluenesulfonyl chloride (3.85 g, 20.2 mmol), N-methylmorpholine (9.30 mL, 84.5 mmol), and dichloromethane (50 mL) were added to the reaction vessel, and the reaction was stirred for 17 hours at room temperature. After completion of the reaction, water was added to the reaction system and extracted with ethyl acetate three times to combine the organic layers. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. After concentration under reduced pressure, the residue was purified by fast silica gel column chromatography (eluent: ethyl acetate/hexane=19:81→40:60) to afford fluoroethyl p-toluenesulfonate (3.79 g, 17.2 mmol, yield >100%) as a pale yellow liquid.1H NMR (600 MHz, CDCl3): δ 7.81 (d, J=8.4 Hz, 2H), δ 7.36 (d, J=8.4 Hz, 2H), 4.63-4.60 (m, 1H), 4.55-4.52 (m, 1H), 4.31-4.27 (m, 1H), 4.26-4.23 (m, 1H), 2.46 (s, 3H). lRMS (EI) Calculated value (C9H11F3O): 218.0, measured value: 218.0.
References
[1] Patent: US2018/30074, 2018, A1. Location in patent: Paragraph 0188-0191
[2] Journal of Labelled Compounds and Radiopharmaceuticals, 2008, vol. 51, # 7, p. 286 - 292
[3] Patent: US2013/177501, 2013, A1. Location in patent: Paragraph 0168
[4] Patent: US9168317, 2015, B2. Location in patent: Page/Page column 25; 26
[5] Patent: US9314541, 2016, B2. Location in patent: Page/Page column 26
2-Fluoroethyl 4-methylbenzenesulfonate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoroethyl 4-methylbenzenesulfonate manufacturers
- Product
- 2-Fluoroethyl 4-methylbenzenesulfonate 383-50-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-09
- Product
- 2-Fluoroethyl 4-methylbenzenesulfonate 383-50-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20t
- Release date
- 2024-06-25
- Product
- 2-Fluoroethyl 4-methylbenzenesulfonate 383-50-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.5%
- Supply Ability
- 100 tons
- Release date
- 2022-02-21