1-N-Cbz-2-Methylpiperazine

Product Name: 1-N-Cbz-2-Methylpiperazine
CAS No.: 444666-46-0
Chemical Name: 1-N-Cbz-2-Methylpiperazine
Synonyms: 1-CBZ-2-METHYLPIPERAZINE;1-N-CBZ-2-METHYL PIPERAZINE;N-1-CBZ-2-METHYL-PIPERAZINE;2-Methylpiperazine, N1-CBZ protected 96%;2-METHYL-PIPERAZINE-1-CARBOXYLIC ACID BENZYL ESTER;1-N-Cbz-2-Methylpiperazine N-1-Cbz-2-Methylpiperazine;2-Methyl-1-piperazinecarboxylic acid phenylmethyl ester;1-Piperazinecarboxylic acid, 2-methyl-, phenylmethyl ester
CBNumber: CB7216486
Molecular Formula: C13H18N2O2
Formula Weight: 234.29
MOL File: 444666-46-0.mol

More

Less

1-N-Cbz-2-Methylpiperazine Property

Boiling point:: 358.0±30.0 °C(Predicted)
Density: 1.105
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 8.48±0.40(Predicted)

More

Less

Safety

HS Code: 2933599590

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

TRC

Product number: B535335
Product name: Benzyl2-Methylpiperazine-1-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC150414
Product name: 1-N-Cbz-2-methylpiperazine
Packaging: 50mg
Price: $56
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC150414
Product name: 1-N-Cbz-2-methylpiperazine
Packaging: 100mg
Price: $97
Updated: 2021/12/16

AK Scientific

Product number: 6133AB
Product name: Benzyl2-methylpiperazine-1-carboxylate
Packaging: 1g
Price: $163
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC150414
Product name: 1-N-Cbz-2-methylpiperazine
Packaging: 250mg
Price: $192.5
Updated: 2021/12/16

More

Less

1-N-Cbz-2-Methylpiperazine Chemical Properties,Usage,Production

Synthesis

109-07-9

501-53-1

444666-46-0

The general procedure for synthesizing 1-N-Cbz-2-methylpiperazine from 2-methylpiperazine and benzyl chloroformate is as follows: referring to Example 5, 10.02 g (0.100 mol) of racemic 2-methylpiperazine was added to a 200 mL four-necked flask equipped with a pH meter and a dropping funnel, followed by the addition of 80.2 g of 1 -butanol to solubilize it, and then the addition of 20.1 g of water (water content of 20.0 wt%). Benzyl chloroformate was slowly added dropwise under vigorous stirring. At the same time, the pH of the reaction system was maintained between 7.5 and 8.5 by dropwise addition of 48 wt% aqueous sodium hydroxide. If necessary, an ice bath was used for cooling to maintain the internal temperature at 23 to 26°C (final water content of 23.0 wt%). After completion of the dropwise addition, the reaction was continued under vigorous stirring for 2 hours. A sample of the reaction solution was analyzed and showed a 50.4% yield of 1-benzyloxycarbonyl-2-methylpiperazine.

References

[1] Patent: EP1548010, 2005, A1. Location in patent: Page/Page column 18
[2] Patent: EP1548010, 2005, A1. Location in patent: Page/Page column 18

1-N-Cbz-2-Methylpiperazine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1-N-Cbz-2-Methylpiperazine Suppliers

China 34 India 1 United Kingdom 4 United States 10 Global 49

ForeChem (Nantong) Technology Co.,Ltd.

Tel: 513-85982855 18921614129
Fax: 051385915507
Email: sales@xianxingpharm.com
Country: China
ProdList: 2986
Advantage: 61

Sichuan Guanghan Bio-Tech Co., Ltd

Tel: +86-28-86127071
Fax: +86-28-86127072
Email: info@sino-produce.com
Country: China
ProdList: 406
Advantage: 66

Shanghai Boc Chemical Co.,Ltd

Tel: 021-34975603-808 18721111801
Fax: +86-21-34975602-805
Email: sales@bocpharma.com
Country: China
ProdList: 1009
Advantage: 64

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Chengdu HappySyn Pharmaceutical Technology Co., Ltd.

Tel: 028-85114309 18982182443
Email: yangli@happysyn.com
Country: China
ProdList: 2151
Advantage: 55

Shanghai Carlow Chemicals Co., Ltd.

Tel: 21-33526724 18930996265
Fax: 37023730
Email: info@carlowchem.com
Country: China
ProdList: 1922
Advantage: 58

Porse Fine Chemical Co.,LTD

Tel: 20-66003216 18666003216
Fax: +86-20-28069063
Email: info@porsefinechemical.com
Country: China
ProdList: 1941
Advantage: 62

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Hangzhou Milestone Pharmtech Co., Ltd.

Tel: 0571-82896630 18969958410
Email: sales_hz@milestonepharmtech.com
Country: China
ProdList: 4895
Advantage: 55

JW & Y Pharmlab Co., Ltd.

Tel: 021-64340559 13651849907;
Fax: 021- 64345308
Email: xinyu_shi@jwypharmlab.com.cn
Country: China
ProdList: 12000
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886750 13927877953
Fax: 0751-2886750
Email: 3005811397@qq.com
Country: China
ProdList: 13305
Advantage: 58

Shanghai Anmike Chemical Co. Ltd.

Tel: 微信 17321281695 18019252918
Fax: 021-31261685
Email: sale@amkchem.com
Country: China
ProdList: 9519
Advantage: 55

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 10007
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

Chengdu AiQun Pharmaceutical Technology Co., Ltd.

Tel: 028-82393420 18108156287
Fax: 028-82393420
Email: 2982653826@qq.com
Country: China
ProdList: 560
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Shanghai zhigan biotechnology co., LTD

Tel
Email: zhiqianbio@126.com
Country: China
ProdList: 19778
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd

Tel: 037188900765 18037465274
Fax: QQ3430974218
Email: enyawanglei@sina.cn
Country: China
ProdList: 13966
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

Shanghai Haohong Scientific Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Shanghai Lingfei Pharmaceutical Technology Co., Ltd

Tel: 15618928656
Email: 771909552@qq.com
Country: China
ProdList: 1265
Advantage: 58

Baoji Didu Pharmaceutical and Chemical Co., Ltd

Tel: 029-029-81148929 17791530722
Email: 1049@dideu.com
Country: China
ProdList: 10011
Advantage: 58

Sichuan Biosynce Pharmatech Co., Ltd.

Tel: +8619950309693
Email: diane@biosynce.com
Country: China
ProdList: 4871
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 49934
Advantage: 58

Beijing Atlantic Scientific Co., Ltd

Tel: --
Fax: --
Email: sales@bjasc.com.cn
Country: China
ProdList: 29
Advantage: 34

Sichuan Unibiochem Co., Ltd

Tel: --
Fax: --
Email: info@unibiochem.com
Country: China
ProdList: 715
Advantage: 46

DSL Chemicals Co.，Ltd

Tel: --
Fax: --
Email: info@DSLChem.com
Country: China
ProdList: 6983
Advantage: 65

444666-46-0, 1-N-Cbz-2-MethylpiperazineRelated Search:

Benzyl benzoate N-Methyl-2-pyrrolidone 1-Methylpyrrolidine 2-Methylpiperazine Kresoxim-methyl Methylparaben 1-Methylpiperazine Methyl acetate Benzyl chloroformate Methyl acrylate Carbobenzoxyhydrazide Piperacillin 4-Nitrobenzyl chloroformate Benzyl formate Bensulfuron methyl 1-Methylimidazole Thiophanate-methyl Methyl

1-CBZ-2-METHYLPIPERAZINE

1-N-CBZ-2-METHYL PIPERAZINE

2-METHYL-PIPERAZINE-1-CARBOXYLIC ACID BENZYL ESTER

N-1-CBZ-2-METHYL-PIPERAZINE

1-N-Cbz-2-Methylpiperazine N-1-Cbz-2-Methylpiperazine

2-Methyl-1-piperazinecarboxylic acid phenylmethyl ester

1-Piperazinecarboxylic acid, 2-methyl-, phenylmethyl ester

2-Methylpiperazine, N1-CBZ protected 96%

444666-46-0