Epipodophyllotoxin

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Epipodophyllotoxin

Product Name: Epipodophyllotoxin
CAS No.: 4375-07-9
Chemical Name: Epipodophyllotoxin
Synonyms: Eipodophyllotoxin;Epipodophyllotoxin;(-)-Epipodophyllotoxin;(-)-Epipodophyllotoxin;Podophyllotoxin 9-Epimer;(5R)-5,8,8aβ,9-Tetrahydro-9α-hydroxy-5β-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-(5aαH)-one;(5R)-5,5aα,8aβ,9-Tetrahydro-9α-hydroxy-5β-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-6(8H)-one;(5S,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[5,6-f][1,3]benzodioxol-8-one;(5S,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one;(5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(3,4,5-trimethoxyphenyl)-9-hydroxyfuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
CBNumber: CB72177765
Molecular Formula: C22H22O8
Formula Weight: 414.41
MOL File: 4375-07-9.mol

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Epipodophyllotoxin Property

Melting point:: 160.3°C
Boiling point:: 453.31°C (rough estimate)
Density: 1.2649 (rough estimate)
refractive index: 1.4480 (estimate)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 13.26±0.40(Predicted)
color: White to Off-White
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: E588645
Product name: Epipodophyllotoxin
Packaging: 1g
Price: $1190
Updated: 2021/12/16

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Epipodophyllotoxin Chemical Properties,Usage,Production

Uses

Epipodophyllotoxins is a naturally occuring antitumors agent extracted from Mayapple plant.

Mechanism of action

Epipodophyllotoxin is a highly effective anticancer drug. Its mechanism of action may be to inhibit topoisomerase II, which in turn prevents the replication of DNA in tumour cells.

Anticancer Research

It is a lignan compound; podophyllotoxin is isolated from the roots of Podophyllumpeltatum and P. emodi. Teniposide and etoposide are the semisynthetic derivativesof epipodophyllotoxin, and they are used for lymphomas and bronchial and testicularcancers (Shoeb 2006). These compounds break DNA molecules during the G2/Mphase in cell cycle by binding to tubulin and irreversibly inhibiting DNAtopoisomerase II (Balunas and Kinghorn 2005). Podophyllotoxin prevents thebreast cancer cell growth by modifying checkpoint kinase 2 (Chk2) signalingpathway and also induces apoptosis in non-small cell lung cancer by cell cyclearrest, autophagy, and ER stress (Singh et al. 2016b).

Epipodophyllotoxin Preparation Products And Raw materials

Raw materials

Preparation Products

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4375-07-9, EpipodophyllotoxinRelated Search:

Podophyllotoxin Hydroxyecdysone beta-Sitosterol 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one Artemether hydroxygenkwanin beta-Eudesmol alpha-Terpineol (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one alpha-Cyperone MOSLOFLAVONE

Eipodophyllotoxin

(-)-Epipodophyllotoxin

(5R)-5,5aα,8aβ,9-Tetrahydro-9α-hydroxy-5β-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-6(8H)-one

(5R)-5,8,8aβ,9-Tetrahydro-9α-hydroxy-5β-(3,4,5-trimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-(5aαH)-one

(5R)-5β-(3,4,5-Trimethoxyphenyl)-7α-(hydroxymethyl)-8α-hydroxy-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole-6β-carboxylic acid 6,7-lactone

(5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(3,4,5-trimethoxyphenyl)-9-hydroxyfuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-, (5R,5aR,8aR,9S)-

Epipodophyllotoxin

(5S,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one

(5S,5aR,8aR,9R)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[5,6-f][1,3]benzodioxol-8-one

Podophyllotoxin 9-Epimer

(-)-Epipodophyllotoxin

(5R)-5β-(3,4,5-Trimethoxyphenyl)-7α-(hydroxymethyl)-8α-hydroxy-5,6,7,8-tetrahydronaphtho[2,3-d]-1,3-dioxole-6β-carboxylic acid 6,7-lactone

( ) Epipodophyllotoxin,spindle,antiproliferative,Apoptosis,American,904166,cancer,mayapple,mitotic,Podophyllum peltatum,()Epipodophyllotoxin,assembly,Inhibitor,inhibit

(5R,5aR,8aR,9S)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one

4375-07-9

Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals