5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine

Product Name: 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
CAS No.: 23669-79-6
Chemical Name: 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
Synonyms: dmt-du;5'-DMT-dU;DMT-2'-dU;5'-O-DMT-dU;5’-O-DMTr-dU;DMT-DEOXYURIDINE;5'-DMT-2'-deoxyuridine;5'-O-DMT-2'-DEOXYURIDINE;2'-Deoxy-5'-O-DMT-uridine;5’-O-DMTr-2’-deoxyuridine
CBNumber: CB7232338
Molecular Formula: C30H30N2O7
Formula Weight: 530.58
MOL File: 23669-79-6.mol

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5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine Property

Melting point:: 120 °C
Density: 1.294±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in acetonitrile at 20mg/ml
form: Powder
pka: 9.39±0.10(Predicted)
color: White to Off-white
optical activity: 7.03°(C=0.01g/mI, DMF, 20°C, 589nm)

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Safety

Hazard Codes: Xn
Risk Statements: 20/22-36/37/38
Safety Statements: 22-26-36
WGK Germany: 3
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: D460528
Product name: 5''-O-(4,4''-Dimethoxytrityl)-2’-deoxyuridine
Packaging: 200mg
Price: $130
Updated: 2021/12/16

Ark Pharm

Product number: P000453457
Product name: 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
Purity: 98%
Packaging: 250mg
Price: $8
Updated: 2021/12/16

Ark Pharm

Product number: P000453457
Product name: 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
Purity: 98%
Packaging: 1g
Price: $19
Updated: 2021/12/16

Biosynth Carbosynth

Product number: ND05965
Product name: 2'-Deoxy-5'-O-DMT-uridine
Packaging: 100mg
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: K265
Product name: 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine
Packaging: 1g
Price: $56
Updated: 2021/12/16

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5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine Chemical Properties,Usage,Production

Chemical Properties

solid

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis

951-78-0

40615-36-9

23669-79-6

To a solution of 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (22.80 g, 99.91 mmol) in anhydrous pyridine (200 mL) was added 4,4'-bis(methoxytrityl)chlorine (37.24 g, 109.90 mmol) and the mixture was allowed to stand at 25 °C for 12 hours. Upon completion of the reaction, the reaction was quenched with saturated NaHCO3/NH4Cl solution (200 mL) and subsequently extracted with ethyl acetate (3 x 200 mL). The organic layers were combined, washed with brine (2 x 100 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by column chromatography (petroleum ether: ethyl acetate, 2:1 to 0:1) to afford the target product 1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (43.00 g, 72.94 mmol) as yellow foam.

References

[1] Bioorganic and Medicinal Chemistry, 1996, vol. 4, # 10, p. 1649 - 1658
[2] Organic letters, 2003, vol. 5, # 6, p. 917 - 919
[3] Journal of the American Chemical Society, 2001, vol. 123, # 15, p. 3405 - 3411
[4] Chemical Research in Toxicology, 2006, vol. 19, # 7, p. 968 - 976
[5] Nucleic Acids Research, 2015, vol. 43, # 11, p. 5275 - 5283

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine Suppliers

China 91 India 3 Slovakia 1 Switzerland 1 United Kingdom 4 United States 13 Global 113

J & K SCIENTIFIC LTD.

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View Lastest Price from 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine 23669-79-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-23

23669-79-6, 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridineRelated Search:

Doxifluridine 2'-Deoxyuridine 4-Methoxyphenylacetone (Trifluoromethoxy)benzene Benzyl alcohol Benzyl benzoate Trifluridine Benzyl bromide Uridine DMT-2′O-TBDMS-rU Phosphoramidite BrdU (Bromodeoxyuridine) uridine diphosphate glucose {= UDP-glucose} DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* DMT-2'O-Methyl-rU Phosphoramidite 5'-O-(4,4'-Dimethoxytrityl)uridine DMT-dT Phosphoramidite 5'-O-Dimethoxytrityl-deoxythymidine 5'-O-(4,4'-Dimethoxytrityl)-thymidine-3'-O-succinic acid

5'-O-Dimethylterephthale-2'-deoxyuridine

dmt-du

5''-O-(4,4''-DIMETHOXYTRITYL)-2''-DEOXYURIDINE 99%

2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)uridine

5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyuridine

2'-Deoxy-5'-O-DMT-uridine

5'-DMT-dU

5'-O-[Bis(4-methoxyphenyl)benzyl]-2'-deoxyuridine

5'-O-DMT-2'-DEOXYURIDINE

DMT-DEOXYURIDINE

5'-DMT-2'-deoxyuridine

DMT-2'-dU

Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-

5'-O-DMT-dU

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine USP/EP/BP

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine, 98%,

1-((2S,4R,5S)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

5’-O-DMTr-dU

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine

5’-O-DMTr-2’-deoxyuridine

5′-O-(4,4′-Dimethoxytrityl)-2′-deoxyuridine, CAS 23669-79-6

23669-79-6

Biochemicals and Reagents

BioChemical

Nucleosides, Nucleotides, Oligonucleotides

Nucleoside Analogs