TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE
- Product Name
- TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE
- CAS No.
- 30189-48-1
- Chemical Name
- TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE
- Synonyms
- -tert-Butyl (1-hydrazinyl-1-oxo-3-phenylpropan-2-yl);N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANINE ACID HYDRAZIDE;TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE;(2S)-2-[(tert-Butoxycarbonyl)amino]-3-phenylpropanohydrazide;L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-, hydrazide;Tert-Butyl N-(1-Hydrazinyl-1-Oxo-3-PhenylpropaN-2-Yl)Carbamate;(S)-tert-Butyl (1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)carbamate
- CBNumber
- CB7233946
- Molecular Formula
- C14H21N3O3
- Formula Weight
- 279.33
- MOL File
- 30189-48-1.mol
TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE Property
- Melting point:
- 131-136°C
- Boiling point:
- 505.3±50.0 °C(Predicted)
- Density
- 1.146±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- 11.42±0.46(Predicted)
- form
- solid
- color
- Off white
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- Hazard Note
- Irritant
- HS Code
- 2922500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- AK487096
- Product name
- (S)-tert-Butyl(1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)carbamate
- Purity
- 97%
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 4658-1-Z7
- Product name
- N-(tert-Butoxycarbonyl)-L-phenylalanine acid hydrazide
- Packaging
- 1g
- Price
- $79
- Updated
- 2021/12/16
- Product number
- AK487096
- Product name
- (S)-tert-Butyl(1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)carbamate
- Purity
- 97%
- Packaging
- 5g
- Price
- $139
- Updated
- 2021/12/16
- Product number
- 7204BA
- Product name
- Tert-butylN-(1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)carbamate
- Packaging
- 1g
- Price
- $142
- Updated
- 2021/12/16
- Product number
- CHM0032287
- Product name
- TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $647.36
- Updated
- 2021/12/16
TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE Chemical Properties,Usage,Production
Synthesis
51987-73-6
30189-48-1
General procedure for the synthesis of tert-butyl (S)-(1-hydrazino-1-oxo-3-phenylpropan-2-yl)carbamate from N-Boc-L-phenylalanine methyl ester: Hydrazine hydrate (170 μL, 3.44 mmol) was added to a methanol (5.4 mL) solution of N-Boc-L-phenylalanine methyl ester (300 mg, 1.07 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was concentrated under reduced pressure by rotary evaporator. The resulting residue was first ground with hexane (2×) and then with a minimum volume of 2:3 hexane/methanol solvent mixture (2×) to afford the target product (S)-(1-hydrazino-1-oxo-3-phenylpropan-2-yl)carbamic acid tert-butyl ester in white solid form (195 mg, 65% yield). The structure of the product was confirmed by 1H NMR (CDCl3) δ 7.41-7.25 (m, 3H), 7.20 (d, J = 6.8 Hz, 2H), 4.39-4.21 (m, 1H), 3.07 (d, J = 7.0 Hz, 2H), 1.42 (s, 9H) and mass spectrometry (ESI+) m/z 280.3 ([M+H]+).
References
[1] New Journal of Chemistry, 2018, vol. 42, # 6, p. 4344 - 4351
[2] Journal of Organic Chemistry, 1995, vol. 60, # 10, p. 3112 - 3120
[3] Angewandte Chemie - International Edition, 2016, vol. 55, # 32, p. 9422 - 9426
[4] Angew. Chem., 2016, vol. 55, # 32, p. 9569 - 9574,6
[5] Patent: WO2013/192286, 2013, A1. Location in patent: Paragraph 00281
TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE Preparation Products And Raw materials
Raw materials
Preparation Products
TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE Suppliers
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