ChemicalBook > CAS DataBase List > 3,4,5-Trimethoxycinnamic acid

3,4,5-Trimethoxycinnamic acid

Product Name: 3,4,5-Trimethoxycinnamic acid
CAS No.: 90-50-6
Chemical Name: 3,4,5-Trimethoxycinnamic acid
Synonyms: AKOS BBS-00000775;RARECHEM BK HC T328;o-methylsinapicacid;OTAVA-BB BB7119152925;TRIMETHOXYCINNAMICACID;3,4,5-Trimethoxycinnamic;3,4,5-Trimethoxyzimtsure;5-TriMethoxycinnaMic acid;3,4,5-Trimethoxycinmic acid;3,4,5-trimethoxy-cinnamicaci
CBNumber: CB7236422
Molecular Formula: C12H14O5
Formula Weight: 238.24
MOL File: 90-50-6.mol

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3,4,5-Trimethoxycinnamic acid Property

Melting point:: 125-127 °C (lit.)
Boiling point:: 300.83°C (rough estimate)
Density: 1.1416 (rough estimate)
vapor pressure: 0-0Pa at 20-25℃
refractive index: 1.4571 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka: 4.48±0.10(Predicted)
form: Solid:crystalline
color: White
BRN: 1537834
InChI: InChI=1S/C12H14O5/c1-15-9-6-8(4-5-11(13)14)7-10(16-2)12(9)17-3/h4-7H,1-3H3,(H,13,14)
InChIKey: YTFVRYKNXDADBI-UHFFFAOYSA-N
SMILES: C(O)(=O)C=CC1=CC(OC)=C(OC)C(OC)=C1
LogP: 0.3-1.1 at 35℃ and pH2-7
CAS DataBase Reference: 90-50-6(CAS DataBase Reference)
EPA Substance Registry System: 2-Propenoic acid, 3-(3,4,5-trimethoxyphenyl)- (90-50-6)

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
WGK Germany: 2
RTECS: GE0722000
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T70408
Product name: 3,4,5-Trimethoxycinnamic acid
Purity: 97%
Packaging: 25g
Price: $58.9
Updated: 2022/05/15

TRC

Product number: T896038
Product name: 3,4,5-Trimethoxycinnamic acid
Packaging: 10g
Price: $60
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK275960
Product name: 3,4,5-Trimethoxycinnamic acid
Purity: 99%
Packaging: 100g
Price: $241
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb594658
Product name: 3,4,5-Trimethoxycinnamic acid
Packaging: 1000mg
Price: $187
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK275960
Product name: 3,4,5-Trimethoxycinnamic acid
Purity: 99%
Packaging: 25g
Price: $73
Updated: 2021/12/16

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3,4,5-Trimethoxycinnamic acid Chemical Properties,Usage,Production

Chemical Properties

white to cream fine crystalline powder

Uses

3-(3,4,5-Trimethoxyphenyl)acrylic acid demonstrates antioxidant activity as it was detected to inhibit lipid peroxidation in rat brain homogenates.

Definition

ChEBI: A methoxycinnamic acid with three methoxy substituents at the 3-, 4- and 5-positions.

Synthesis

141-82-2

86-81-7

20329-98-0

Example IV Synthesis of 3,4,5-trimethoxycinnamic acid (by microwave radiation method): in a 100 mL Erlenmeyer flask, a mixture of 3,4,5-trimethoxybenzaldehyde (5.0 g, 0.025 mol) and malonic acid (5.30 g, 0.050 mol) was added, followed by piperidine (4-8 mL) and acetic acid (25-35 mL). The flask was fitted with a loose funnel at the top and the mixture was shaken well and placed in a microwave oven and microwaved in batches for 4-8 min. Upon completion of the reaction, the cooled mixture was poured into ice-cold water and acidified with 5% HCl solution. The precipitated yellow solid was collected by filtration and recrystallized by aqueous ethanol to give 3,4,5-trimethoxycinnamic acid in 88% yield; the melting point was 127 °C (literature value 126-128 °C). The spectral data of the product were consistent with those reported in the literature: 1H NMR (CDCl3) δ 7.73 (1H, d, J = 16.0 Hz, -CH=CH-COOH), 6.78 (2H, s, H-2 and H-6), 6.38 (1H, d, J = 16.0 Hz, CH=CH-COOH), 3.91 (9H, s, 3-OCH3, 4- OCH3, 5-OCH3); 13C NMR: δ 172.6 (COOH), 153.8 (C-3 and C-5), 147.4 (C-4), 140.8 (CH=CH-COOH), 129.8 (C-1), 116.8 (CH=CH-COOH), 105.8 (C-2 and C-6), 61.4 (4- OCH3), 56.5 (3-OCH3 and 5-OCH3).

target

5-HT Receptor | ERK | GABA Receptor | HIF-2

References

[1] MedChemComm, 2017, vol. 8, # 4, p. 755 - 766
[2] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 473 - 482
[3] Medicinal Chemistry Research, 2016, vol. 25, # 6, p. 1074 - 1086
[4] Chemistry Letters, 2003, vol. 32, # 12, p. 1186 - 1187
[5] Patent: US2004/118673, 2004, A1. Location in patent: Page 7

3,4,5-Trimethoxycinnamic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,4,5-Trimethoxycinnamic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3,4,5-Trimethoxycinnamic acid 90-50-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-29

Shandong Deshang Chemical Co., Ltd.

Product: 3,4,5-Trimethoxycinnamic acid 90-50-6
Price: US $10.00-4.50/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 tons
Release date: 2024-08-28

airuikechemical co., ltd.

Product: 3,4,5-trimethoxycinmic acid 90-50-6
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-03-27

90-50-6, 3,4,5-Trimethoxycinnamic acidRelated Search:

trans-Cinnamic acid Octyl 4-methoxycinnamate 3-(Trifluoromethyl)cinnamic acid Methyl cinnamate Ethyl cinnamate alpha-Methylcinnamic acid Cinnamyl cinnamate 3,4-Dimethoxycinnamonitrile 4-Methoxycinnamic acid 3,4,5-TRIMETHOXYCINNAMIC ACID ETHYL ESTER 3,4,5-TRIMETHOXYCINNAMIC ACID SODIUM SALT trans-2,4,5-Trimethoxycinnamic acid TRANS-2,3,4-TRIMETHOXYCINNAMIC ACID,2,3,4-TRIMETHOXYCINNAMIC ACID,Trans-2,3,4-trimethoxycinnamic acid 99% 3,4,5-Trimethoxycinnamic acid, methyl reserpate 2,4,6-TRIMETHOXYCINNAMIC ACID 2,4,6-TRIMETHOXYCINNAMIC ACID ETHYL ESTER 3,4,5-Trimethoxycinnamic acid ISOPENTYL TRIMETHOXYCINNAMATE TRISILOXANE

RARECHEM BK HC T328

OTAVA-BB BB7119152925

3-(3,4,5-trimethoxyphenyl)-2-propenoicaci

3-(3,4,5-trimethoxyphenyl)-2-propenoicacid

3,4,5-trimethoxy-cinnamicaci

3,4,5-TriMethoxycinnaMic acid, predoMinantly trans, 99% 5GR

3, 4, 5 - triMethoxy CinnaMate

3,4,5-TrimethoxyClnnamic aCld

3,4,5-Trimethoxycinmic acid

2-Propenoicacid, 3-(3,4,5-trimethoxyphenyl)-

(E)-3-(3,4,5-trimethoxyphenyl)-2-propenoate

3,4,5-trimethoxyphenylacrylicacid

o-methylsinapicacid

(E)-3-(3,4,5-TRIMETHOXY-PHENYL)-ACRYLIC ACID

3,4,5-TRIMETHOXYCINNAMIC ACID

3-(3,4,5-TRIMETHOXYPHENYL)ACRYLIC ACID

AKOS BBS-00000775

3,4,5-Trimethoxycinnamic

3,4,5-TRIMETHOXYCINNAMIC ACID, 97%, PRED OMINANTLY TRANS

3,4,5-TrimethoxycinnamicAcid,~99%

3,4,5-Trimethoxycinnamic acid, predominantly trans, 99%

(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoic acid

TRIMETHOXYCINNAMICACID

3,4,5-Trimethoxyzimtsure

5-TriMethoxycinnaMic acid

3-(3,4,5-Trimethoxyphenyl)propenoic acid

3,4,5-Trimethoxybenzeneacrylic acid

3,4,5-Trimethoxycinnamic acid, 99%, predominantly trans

(2E)-3-(3,4,5-trimethoxyphenyl)acrylic acid

,4,5-Trimethoxycinnamic acid

3,4,5-Trimethoxycinnamic acid,3,4,5-Trimethoxyzimtsure,RARECHEM BK HC T328,3,4,5-Trimethoxycinnamic,TRIMETHOXYCINNAMICACID,o-

3,4,5-TrimethoxyClnnamic acid

3,4,5-Trimethoxycinnamic acid, 10 mM in DMSO

90-50-6

95-50-6

Carboxylic Acids

Carbonyl Compounds

C11 to C12

Building Blocks

Organic Building Blocks

Aromatic Cinnamic Acids, Esters and Derivatives

Cinnamic acid

Organic acids

C11 to C12

Carbonyl Compounds

Carboxylic Acids

Inhibitors

90-50-6