3,4,5-Trimethoxycinnamic acid
- Product Name
- 3,4,5-Trimethoxycinnamic acid
- CAS No.
- 90-50-6
- Chemical Name
- 3,4,5-Trimethoxycinnamic acid
- Synonyms
- AKOS BBS-00000775;RARECHEM BK HC T328;o-methylsinapicacid;OTAVA-BB BB7119152925;TRIMETHOXYCINNAMICACID;3,4,5-Trimethoxycinnamic;3,4,5-Trimethoxyzimtsure;5-TriMethoxycinnaMic acid;3,4,5-Trimethoxycinmic acid;3,4,5-trimethoxy-cinnamicaci
- CBNumber
- CB7236422
- Molecular Formula
- C12H14O5
- Formula Weight
- 238.24
- MOL File
- 90-50-6.mol
3,4,5-Trimethoxycinnamic acid Property
- Melting point:
- 125-127 °C (lit.)
- Boiling point:
- 300.83°C (rough estimate)
- Density
- 1.1416 (rough estimate)
- vapor pressure
- 0-0Pa at 20-25℃
- refractive index
- 1.4571 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- pka
- 4.48±0.10(Predicted)
- form
- Solid:crystalline
- color
- White
- BRN
- 1537834
- InChI
- InChI=1S/C12H14O5/c1-15-9-6-8(4-5-11(13)14)7-10(16-2)12(9)17-3/h4-7H,1-3H3,(H,13,14)
- InChIKey
- YTFVRYKNXDADBI-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C=CC1=CC(OC)=C(OC)C(OC)=C1
- LogP
- 0.3-1.1 at 35℃ and pH2-7
- CAS DataBase Reference
- 90-50-6(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Propenoic acid, 3-(3,4,5-trimethoxyphenyl)- (90-50-6)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T70408
- Product name
- 3,4,5-Trimethoxycinnamic acid
- Purity
- 97%
- Packaging
- 25g
- Price
- $58.9
- Updated
- 2022/05/15
- Product number
- T896038
- Product name
- 3,4,5-Trimethoxycinnamic acid
- Packaging
- 10g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- JK275960
- Product name
- 3,4,5-Trimethoxycinnamic acid
- Purity
- 99%
- Packaging
- 100g
- Price
- $241
- Updated
- 2021/12/16
- Product number
- orb594658
- Product name
- 3,4,5-Trimethoxycinnamic acid
- Packaging
- 1000mg
- Price
- $187
- Updated
- 2021/12/16
- Product number
- JK275960
- Product name
- 3,4,5-Trimethoxycinnamic acid
- Purity
- 99%
- Packaging
- 25g
- Price
- $73
- Updated
- 2021/12/16
3,4,5-Trimethoxycinnamic acid Chemical Properties,Usage,Production
Chemical Properties
white to cream fine crystalline powder
Uses
3-(3,4,5-Trimethoxyphenyl)acrylic acid demonstrates antioxidant activity as it was detected to inhibit lipid peroxidation in rat brain homogenates.
Definition
ChEBI: A methoxycinnamic acid with three methoxy substituents at the 3-, 4- and 5-positions.
Synthesis
141-82-2
86-81-7
20329-98-0
Example IV Synthesis of 3,4,5-trimethoxycinnamic acid (by microwave radiation method): in a 100 mL Erlenmeyer flask, a mixture of 3,4,5-trimethoxybenzaldehyde (5.0 g, 0.025 mol) and malonic acid (5.30 g, 0.050 mol) was added, followed by piperidine (4-8 mL) and acetic acid (25-35 mL). The flask was fitted with a loose funnel at the top and the mixture was shaken well and placed in a microwave oven and microwaved in batches for 4-8 min. Upon completion of the reaction, the cooled mixture was poured into ice-cold water and acidified with 5% HCl solution. The precipitated yellow solid was collected by filtration and recrystallized by aqueous ethanol to give 3,4,5-trimethoxycinnamic acid in 88% yield; the melting point was 127 °C (literature value 126-128 °C). The spectral data of the product were consistent with those reported in the literature: 1H NMR (CDCl3) δ 7.73 (1H, d, J = 16.0 Hz, -CH=CH-COOH), 6.78 (2H, s, H-2 and H-6), 6.38 (1H, d, J = 16.0 Hz, CH=CH-COOH), 3.91 (9H, s, 3-OCH3, 4- OCH3, 5-OCH3); 13C NMR: δ 172.6 (COOH), 153.8 (C-3 and C-5), 147.4 (C-4), 140.8 (CH=CH-COOH), 129.8 (C-1), 116.8 (CH=CH-COOH), 105.8 (C-2 and C-6), 61.4 (4- OCH3), 56.5 (3-OCH3 and 5-OCH3).
target
5-HT Receptor | ERK | GABA Receptor | HIF-2
References
[1] MedChemComm, 2017, vol. 8, # 4, p. 755 - 766
[2] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 473 - 482
[3] Medicinal Chemistry Research, 2016, vol. 25, # 6, p. 1074 - 1086
[4] Chemistry Letters, 2003, vol. 32, # 12, p. 1186 - 1187
[5] Patent: US2004/118673, 2004, A1. Location in patent: Page 7
3,4,5-Trimethoxycinnamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3,4,5-Trimethoxycinnamic acid Suppliers
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- Fax
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- chemcontrol@nextra.sk
- Country
- Slovakia
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View Lastest Price from 3,4,5-Trimethoxycinnamic acid manufacturers
- Product
- 3,4,5-Trimethoxycinnamic acid 90-50-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-29
- Product
- 3,4,5-Trimethoxycinnamic acid 90-50-6
- Price
- US $10.00-4.50/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 tons
- Release date
- 2024-08-28
- Product
- 3,4,5-trimethoxycinmic acid 90-50-6
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-03-27