Levomefolic Acid

Description Mechanism Medical application Storage

Product Name: Levomefolic Acid
CAS No.: 31690-09-2
Chemical Name: Levomefolic Acid
Synonyms: 5-MTHF;L-5-Methyltetrahydrofolate;L-5-Methyltetrahydrofolic acid;(6S)-5-Methyltetrahydrofolic acid;N-[4-[[[(6S)-2-Amino-5-methyl-1,4,5,6,7,8-hexahydro-4-oxopteridine-6-yl]methyl]amino]benzoyl]-L-glutamic acid;l-N5;8S95DH25XC;L-methyl acid;5lLCH3-folateH4;Unii-8S95dh25xc
CBNumber: CB72379121
Molecular Formula: C20H25N7O6
Formula Weight: 459.46
MOL File: 31690-09-2.mol

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Levomefolic Acid Property

Melting point:: 215-218oC
Density: 1.62
storage temp.: Sealed in dry,Room Temperature
solubility: Aqueous Base (Slightly, Heated, Sonicated), DMSO (Slightly)
pka: 3.51±0.10(Predicted)
form: Solid
color: Off-White to Light Green

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: L0335
Product name: Levomefolic Acid
Packaging: 50MG
Price: $214
Updated: 2024/03/01

TCI Chemical

Product number: L0335
Product name: Levomefolic Acid
Packaging: 250MG
Price: $644
Updated: 2024/03/01

TRC

Product number: L375730
Product name: Levomefolic Acid
Packaging: 5mg
Price: $185
Updated: 2021/12/16

Usbiological

Product number: I0785-77
Product name: L-N5-
Packaging: 1mg
Price: $355
Updated: 2021/12/16

Usbiological

Product number: 015555
Product name: Levomefolic Acid
Packaging: 5mg
Price: $496
Updated: 2021/12/16

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Levomefolic Acid Chemical Properties,Usage,Production

Description

Levomefolic Acid is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid. It has been proposed for treatment of cardiovascular disease.

Mechanism

It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate. Levomefolic acid is generated by methylenetetrahydrofolate reductase (MTHFR) from 5,10-methylenetetrahydrofolate (MTHF) and used to recycle homocysteine back to methionine by methionine synthase (MS).

Medical application

Levomefolic acid (5-MTHF) is the natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. IC50 value: Target: Folate analogLevomefolic acid has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. Levomefolic acid (5-MTHF) has the prominent antioxidant activity. A high dose of 5-MTHF or folic acid does not influence Natural killer (NK) cell function in vitro.
Preliminary research suggests that levomefolic acid (L-methylfolate) taken with a first-line antidepressant may provide an adjunctive antidepressant effect for individuals who do not respond or have only a partial therapeutic response to SSRI or SNRI medication,and might be a more cost-effective adjunctive agent than second-generation antipsychotics.

Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Uses

A natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid. It has been proposed for treatment of cardiovascular disease.

Uses

As a natural, active form of folic acid, Levomefolic Acid can be used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supple

Definition

ChEBI: 5-methyltetrahydrofolic acid is a tetrahydrofolic acid that is 5,6,7,8-tetrahydrofolic acid substituted by a methyl group at position 5. It has a role as a human metabolite. It is functionally related to a 5,6,7,8-tetrahydrofolic acid. It is a conjugate acid of a 5-methyltetrahydrofolate(2-).

Levomefolic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Levomefolic Acid Suppliers

Americas 1 Canada 1 China 174 Europe 1 India 7 Japan 1 United States 13 Global 198

Zhejiang Zhulong Biotechnology Co.,Ltd

Tel: 15868114325
Email: panybmail@163.com
Country: China
ProdList: 8
Advantage: 58

Nanjing jingzhu bio-technology Co.,Ltd

Tel: 025-52794219 13140719234
Email: 2498234449@qq.com
Country: China
ProdList: 74
Advantage: 58

SU ZHOU EVOL BIO-TECH CO.,LTD

Tel: 15706135552
Email: sales@evol-biotech.com
Country: China
ProdList: 20
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 8418
Advantage: 55

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4940
Advantage: 60

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

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View Lastest Price from Levomefolic Acid manufacturers

Jinan Jianfeng Chemical Co., Ltd

Product: Levomefolic Acid 31690-09-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 3000kg
Release date: 2023-12-08

Hebei Chuanghai Biotechnology Co,.LTD

Product: Levomefolic Acid 31690-09-2
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-20

Shaanxi Dideu Medichem Co. Ltd

Product: Levomefolic Acid 31690-09-2
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000Tons
Release date: 2024-08-05

31690-09-2, Levomefolic AcidRelated Search:

(1R,4aS,4bR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,9,10,10a-octahydro phenanthrene-1-carboxylic acid Tetrahydrofurfuryl alcohol DIHYDROFOLIC ACID Glycine L-Tetrahydrofolic Acid Folic acid

(6S)-5-Methyltetrahydrofolic acid

5lLCH3-folateH4

L(-)-5-Methyl-5,6,7,8-tetrahydrofolic acid

lL-5-Methyltetrahydrofolic acid

N-[4-[[[(6S)-2-Amino-5-methyl-1,4,5,6,7,8-hexahydro-4-oxopteridine-6-yl]methyl]amino]benzoyl]-L-glutamic acid

N-[4-[[[[(6S)-2-Amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxopteridin]-6-yl]methyl]amino]benzoyl]-L-glutamic acid

(S)-N-[4-[[(2-Amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid

Levomefolic acid

L-5-Methyltetrahydrofolate

5-Methyl-(6S)-tetrahydrofolic Acid

LevoMefolic Acid (See also L375720)

l-N5

Methyl-L-tetrahydrofolic A

N-[4-[[[(6S)-2-AMino-3,4,5,6,7,8-hexahydro-5-Methyl-4-oxo-6-pteridinyl]Methyl]aMino]benzoyl]-L-glutaMic Acid

5-MTHF

(S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)

L-Glutamic acid, N-(4-(((2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, (S)-

Unii-8S95dh25xc

(S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzami

L-5-Methyltetrahydrofolic acid

L-5-Methyltetrahydrofola acide

(S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid

Levomefolate (5-methyl-tetrahydrofolic acid)

L-methyl acid

L-Glutamic acid, N-[4-[[[(6S)-2-amino-3,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-

(S)-2-[4-[[[(S)-2-Amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl]amino]benzamido]pentanedioic Acid

N-[4-[[((6S)-2-Amino-5-methyl-4-oxo-1,4,5,6,7,8-hexahydro-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid

Levomefolic Acid USP/EP/BP

(S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pen

Levomefolic Acid D3Q: What is Levomefolic Acid D3 Q: What is the CAS Number of Levomefolic Acid D3 Q: What is the storage condition of Levomefolic Acid D3 Q: What are the applications of Levomefolic Acid D3

8-pentamethoxyflavone

(S)-2-(4-((((S)-2-Amino-5-methyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzamido)pentanedioicaci

L-Methyl Tetra Folate

(6S)-5-Methyltetrahydrofolic Acid in DMSO:H2O=1:1

5-Methyltetrahydrofolic Acid-[13C,d3] in DMSO:H2O=1:1

8S95DH25XC

31690-09-2

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Aromatics

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Intermediates & Fine Chemicals

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