Uses
ChemicalBook > CAS DataBase List > 3-Fluoro-4-Bromoobenzyl Cyanide

3-Fluoro-4-Bromoobenzyl Cyanide

Uses
Product Name
3-Fluoro-4-Bromoobenzyl Cyanide
CAS No.
499983-13-0
Chemical Name
3-Fluoro-4-Bromoobenzyl Cyanide
Synonyms
3-Fluoro-4-broMobenzyl cyanide;4-Bromo-3-fluorobenzyl cyanide;3-Fluoro-4-Bromoobenzyl Cyanide;4-Bromo-3-fluorophenylacetonitrile;4-Bromo-3-fluorobenzeneacetonitrile;3-Fluoro-4-bromophenyl acetonitrile;Benzeneacetonitrile, 4-bromo-3-fluoro-;2-(4-BroMo-3-fluorophenyl)acetonitrile
CBNumber
CB72485635
Molecular Formula
C8H5BrFN
Formula Weight
214.03
MOL File
499983-13-0.mol
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3-Fluoro-4-Bromoobenzyl Cyanide Property

Boiling point:
279℃
Density 
1.573
Flash point:
122℃
storage temp. 
2-8°C
Appearance
Off-white to light yellow Solid
InChI
InChI=1S/C8H5BrFN/c9-7-2-1-6(3-4-11)5-8(7)10/h1-2,5H,3H2
InChIKey
CGDCFGJXTOGEGD-UHFFFAOYSA-N
SMILES
C1(CC#N)=CC=C(Br)C(F)=C1
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Safety

RIDADR 
3439
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
B677853
Product name
2-(4-Bromo-3-fluorophenyl)acetonitrile
Packaging
250mg
Price
$55
Updated
2021/12/16
AK Scientific
Product number
J98092
Product name
4-Bromo-3-fluorophenylacetonitrile
Packaging
5g
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
3637-B-X4
Product name
4-Bromo-3-fluorophenylacetonitrile
Packaging
1g
Price
$64
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB105504
Product name
2-(4-bromo-3-fluorophenyl)acetonitrile
Packaging
1g
Price
$75
Updated
2021/12/16
AK Scientific
Product number
J98092
Product name
4-Bromo-3-fluorophenylacetonitrile
Packaging
10g
Price
$100
Updated
2021/12/16
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3-Fluoro-4-Bromoobenzyl Cyanide Chemical Properties,Usage,Production

Uses

3-Fluoro-4-bromophenylacetonitrile is a commonly used chemical intermediate, prepared by cyanidation.

Chemical Properties

Off-white powder

Synthesis

127425-73-4

773837-37-9

499983-13-0

A mixture of 3-fluoro-4-bromobenzyl bromide (27 mmol) and sodium cyanide (2.38 g, 54 mmol, 2.0 eq.) in ethanol (100 mL) was heated and reacted at 80 °C for 2 hours. Upon completion of the reaction, the mixture was concentrated to dryness under vacuum, followed by suspension of the residue in water and extraction with ethyl acetate. The organic phase was washed with brine and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give the crude product as a heavy oil. Purification by silica gel column chromatography (eluent gradient: 2%→12% ethyl acetate/hexane) resulted in 3-fluoro-4-bromophenylacetonitrile as white acicular crystals (1.96 g, 35% overall yield in two steps).

References

[1] Patent: WO2011/15287, 2011, A2. Location in patent: Page/Page column 13; 14
[2] Patent: US2011/39934, 2011, A1. Location in patent: Page/Page column 5
[3] Patent: EP2700643, 2014, A1. Location in patent: Paragraph 0235
[4] Patent: US2015/368278, 2015, A1. Location in patent: Paragraph 1263
[5] Patent: WO2017/98440, 2017, A1. Location in patent: Page/Page column 184

3-Fluoro-4-Bromoobenzyl Cyanide Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Fluoro-4-Bromoobenzyl Cyanide Suppliers

Canada 1 China 99 India 1 Switzerland 1 United Kingdom 3 United States 10 Global 115
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
Advantage
74
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View Lastest Price from 3-Fluoro-4-Bromoobenzyl Cyanide manufacturers

R&D Scientific Inc.
Product
4-Bromo-3-fluorophenylacetonitrile 499983-13-0
Price
US $500.00/g
Min. Order
1g
Purity
98
Supply Ability
500 Kg
Release date
2024-02-12
Career Henan Chemical Co
Product
3-Fluoro-4-Bromoobenzyl Cyanide 499983-13-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-17

499983-13-0, 3-Fluoro-4-Bromoobenzyl CyanideRelated Search:

α-Bromo-2,3,4,5,6-pentafluorotoluene 4-Fluorobenzyl bromide 1-BroMoheptadecafluorooctane 4-BROMO-3-FLUOROPHENYLACETIC ACID 4-Bromo-3-fluorobenzaldehyde

  • 3-Fluoro-4-Bromoobenzyl Cyanide
  • 3-Fluoro-4-bromophenyl acetonitrile
  • 4-Bromo-3-fluorobenzeneacetonitrile
  • 4-Bromo-3-fluorophenylacetonitrile
  • 3-Fluoro-4-broMobenzyl cyanide
  • 2-(4-BroMo-3-fluorophenyl)acetonitrile
  • 4-Bromo-3-fluorobenzyl cyanide
  • Benzeneacetonitrile, 4-bromo-3-fluoro-
  • 499983-13-0