ChemicalBook > CAS DataBase List > VU0155041

VU0155041

Product Name: VU0155041
CAS No.: 1093757-42-6
Chemical Name: VU0155041
Synonyms: UV0155041;VU0155041;VU0155041;VU-0155041;VU0155041, 10 mM in DMSO;VU0155041, positive allosteric mGluR4 agonist;(±)-cis-2-(3,5-DichlorophenylcarbaMoy)cyclohexanecarboxylic Acid;(±)-cis-2-(3,5-Dichlorophenylcarbamoy)cyclohexanecarboxylic Acid;(±)-cis-2-(3,5-Dicholorphenylcarbamoyl)cyclohexanecarboxylic acid;(1S,2R)-2-((3,5-DICHLOROPHENYL)CARBAMOYL)CYCLOHEXANECARBOXYLIC ACID;cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylicacid
CBNumber: CB72487583
Molecular Formula: C14H15Cl2NO3
Formula Weight: 316.18
MOL File: 1093757-42-6.mol

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VU0155041 Property

Boiling point:: 540.2±50.0 °C(Predicted)
Density: 1.429±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
form: white powder
pka: 4.48±0.44(Predicted)
color: Pale purple to purple

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 3248
Product name: VU0155041
Purity: ≥99%(HPLC)
Packaging: 10
Price: $59
Updated: 2021/12/16

Tocris

Product number: 3248
Product name: VU0155041
Purity: ≥99%(HPLC)
Packaging: 50
Price: $249
Updated: 2021/12/16

Usbiological

Product number: 257053
Product name: VU 0155041
Packaging: 10mg
Price: $290
Updated: 2021/12/16

TRC

Product number: D436000
Product name: (±)-cis-2-(3,5-Dichlorophenylcarbamoy)cyclohexanecarboxylicAcid
Packaging: 500mg
Price: $1175
Updated: 2021/12/16

ApexBio Technology

Product number: B7329
Product name: VU0155041
Packaging: 10mg
Price: $93
Updated: 2021/12/16

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VU0155041 Chemical Properties,Usage,Production

Uses

Acts as an allosteric modulator (PAM) of mGluR4, part of the class of receptors influencing Parkinson’s disease and it’s expression.

Biological Activity

VU0155041 is a mixed allosteric agonist/positive allosteric modulator (PAM) of mGluR4. VU0155041 is approximately 8-fold more potent than PHCCC and does not show any significant potentiator or antagonist activity at other mGluR subtypes. It is soluble in an aqueous vehicle and intracerebroventricular administration of 31-316 nmol of VU0155041 dose-dependently decreased haloperidol-induced catalepsy and reserpine-induced akinesia in rats. VU0155041 exhibits selectivity for mGluR4 relative to 67 different targets and does not affect the function of striatal NMDA receptors.', 'VU0155041 is a positive allosteric modulator of the metabotropic glutamate receptor subtype 4. It also shows some direct agonist activity, but at a site different from the glutamate binding site. /VU0155041 is approximately 8-fold more potent than PHCCC and enhances the activity of glutamate also about 8-fold. It shows promising anti-Parkinsonian effects in animal models of Parkinsonμs disease.

in vivo

VU0155041 (31 nmol, 93 nmol; i.c.v.) reverses catalepsy induced by the dopamine D2 receptor antagonist Haloperidol (1.5 mg/kg, i.p.) in rats^[1].
VU0155041 (93 nnmol, 316 nmol; i.c.v.) reverses Reserpine (HY-N0480)-induced akinesia in rats^[1].

Animal Model:	Third ventricle cannulated (TVC) Male Sprague-Dawley rats (225-255 g)^[1]
Dosage:	31 nmol, 93 nmol (10 μL)
Administration:	Intracerebroventrical injection, after the Haloperidol (1.5 mg/kg) treatment 2 hours
Result:	Decreased the cataleptic effects of Haloperidol, and the effects still presented 30 min after infusion.

IC 50

Human mGlu₄: 798 nM (EC₅₀); Rat mGlu₄: 693 nM (EC₅₀)

VU0155041 Preparation Products And Raw materials

Raw materials

Preparation Products

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VU0155041 Suppliers

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1093757-42-6, VU0155041Related Search:

VU 591 hydrochloride 2-Naphthalenecarboxamide, N-[(1S)-2-[4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-, hydrochloride (1:1) N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide VU 0364770 N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide VU 0357121 VU 0364439 VU 0357017 hydrochloride VU 0463841 [Hexahydro-5-(4-pyridinyl)pyrrolo[3,4-c]pyrrol-2(1H)-yl][1-(5-isoquinolinylsulfonyl)-3-azetidinyl]-Methanone N-(5-chloro-2-methoxyphenyl)-2-[4-(4-methylpiperidin-1-yl)sulfonylpiperazin-1-yl]acetamide VU0453595 5-[1-(2-ethoxyphenyl)sulfonylazetidin-3-yl]-3-thiophen-3-yl-1,2,4-oxadiazole VU 0360223 2(5H)-Furanone, 3-(3-fluorophenyl)-4-(4-methoxyphenyl)- VU 0360172 cyclopentyl 1,6-dimethyl-4-(6-nitro-1,3-benzodioxol-5-yl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide

VU0155041

cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylicacid

UV0155041

(1R,2S)-2-[(3,5-dichlorophenyl)carbamoyl]cyclohexane-1-carboxylic acid

(±)-cis-2-(3,5-DichlorophenylcarbaMoy)cyclohexanecarboxylic Acid

(±)-cis-2-(3,5-Dicholorphenylcarbamoyl)cyclohexanecarboxylic acid

rel-(1R,2S)-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylic acid

VU0155041;VU-0155041

Cyclohexanecarboxylic acid, 2-[[(3,5-dichlorophenyl)amino]carbonyl]-, (1R,2S)-rel-

(1S,2R)-2-((3,5-DICHLOROPHENYL)CARBAMOYL)CYCLOHEXANECARBOXYLIC ACID

Metabotropic glutamate receptors,glutamate,mGluR,VU0155041,VU 0155041,partial,Inhibitor,inhibit,mGluR4

rel-(1R,2S)-2-((3,5-Dichlorophenyl)carbamoyl)cyclohexane-1-carboxylic acid

(1S,2R)-2-[(3,5-dichlorophenyl)carbamoyl]cyclohexane-1-carboxylic acid

VU0155041, positive allosteric mGluR4 agonist

VU0155041, 10 mM in DMSO

(±)-cis-2-(3,5-Dichlorophenylcarbamoy)cyclohexanecarboxylic Acid

1093757-42-6

Glutamate