VU0155041
- Product Name
- VU0155041
- CAS No.
- 1093757-42-6
- Chemical Name
- VU0155041
- Synonyms
- UV0155041;VU0155041;VU0155041;VU-0155041;VU0155041, 10 mM in DMSO;VU0155041, positive allosteric mGluR4 agonist;(±)-cis-2-(3,5-DichlorophenylcarbaMoy)cyclohexanecarboxylic Acid;(±)-cis-2-(3,5-Dichlorophenylcarbamoy)cyclohexanecarboxylic Acid;(±)-cis-2-(3,5-Dicholorphenylcarbamoyl)cyclohexanecarboxylic acid;(1S,2R)-2-((3,5-DICHLOROPHENYL)CARBAMOYL)CYCLOHEXANECARBOXYLIC ACID;cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylicacid
- CBNumber
- CB72487583
- Molecular Formula
- C14H15Cl2NO3
- Formula Weight
- 316.18
- MOL File
- 1093757-42-6.mol
VU0155041 Property
- Boiling point:
- 540.2±50.0 °C(Predicted)
- Density
- 1.429±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
- form
- white powder
- pka
- 4.48±0.44(Predicted)
- color
- Pale purple to purple
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 3248
- Product name
- VU0155041
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $59
- Updated
- 2021/12/16
- Product number
- 3248
- Product name
- VU0155041
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $249
- Updated
- 2021/12/16
- Product number
- 257053
- Product name
- VU 0155041
- Packaging
- 10mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- D436000
- Product name
- (±)-cis-2-(3,5-Dichlorophenylcarbamoy)cyclohexanecarboxylicAcid
- Packaging
- 500mg
- Price
- $1175
- Updated
- 2021/12/16
- Product number
- API0008269
- Product name
- VU0155041
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $540
- Updated
- 2021/12/16
VU0155041 Chemical Properties,Usage,Production
Uses
Acts as an allosteric modulator (PAM) of mGluR4, part of the class of receptors influencing Parkinson’s disease and it’s expression.
Biological Activity
VU0155041 is a mixed allosteric agonist/positive allosteric modulator (PAM) of mGluR4. VU0155041 is approximately 8-fold more potent than PHCCC and does not show any significant potentiator or antagonist activity at other mGluR subtypes. It is soluble in an aqueous vehicle and intracerebroventricular administration of 31-316 nmol of VU0155041 dose-dependently decreased haloperidol-induced catalepsy and reserpine-induced akinesia in rats. VU0155041 exhibits selectivity for mGluR4 relative to 67 different targets and does not affect the function of striatal NMDA receptors.', 'VU0155041 is a positive allosteric modulator of the metabotropic glutamate receptor subtype 4. It also shows some direct agonist activity, but at a site different from the glutamate binding site. /VU0155041 is approximately 8-fold more potent than PHCCC and enhances the activity of glutamate also about 8-fold. It shows promising anti-Parkinsonian effects in animal models of Parkinsonμs disease.
in vivo
VU0155041 (31 nmol, 93 nmol; i.c.v.) reverses catalepsy induced by the dopamine D2 receptor antagonist Haloperidol (1.5 mg/kg, i.p.) in rats[1].
VU0155041 (93 nnmol, 316 nmol; i.c.v.) reverses Reserpine (HY-N0480)-induced akinesia in rats[1].
| Animal Model: | Third ventricle cannulated (TVC) Male Sprague-Dawley rats (225-255 g)[1] |
| Dosage: | 31 nmol, 93 nmol (10 μL) |
| Administration: | Intracerebroventrical injection, after the Haloperidol (1.5 mg/kg) treatment 2 hours |
| Result: | Decreased the cataleptic effects of Haloperidol, and the effects still presented 30 min after infusion. |
IC 50
Human mGlu4: 798 nM (EC50); Rat mGlu4: 693 nM (EC50)