Synthesis
ChemicalBook > CAS DataBase List > 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid

4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid

Synthesis
Product Name
4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid
CAS No.
168626-74-2
Chemical Name
4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid
Synonyms
Conivaptan-4;Conivaptan impurity D;Conivaptan Impurity 1;Conivaptan intermediate;4-(2-Phenylbenzamido)benzoic acid;Conivaptan hydrochloride Impurity D;4-[(2-phenylbenzoyl)amino]benzoic acid;4-[(2-Biphenylcarbonyl)amino]benzoic acid;4-[(biphenyl-2-carbonyl)amino]benzoic acid;4-[(2-Biphenylylcarbonyl)amino]benzoic acid
CBNumber
CB72510027
Molecular Formula
C20H15NO3
Formula Weight
317.34
MOL File
168626-74-2.mol
More
Less

4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid Property

Melting point:
246-248℃
Boiling point:
474.5±38.0 °C(Predicted)
Density 
1.29
pka
4.26±0.10(Predicted)
InChI
InChI=1S/C20H15NO3/c22-19(21-16-12-10-15(11-13-16)20(23)24)18-9-5-4-8-17(18)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)
InChIKey
VIWLAZSPFNNYTJ-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=C(NC(C2=CC=CC=C2C2=CC=CC=C2)=O)C=C1
More
Less

Safety

HazardClass 
IRRITANT
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Matrix Scientific
Product number
060040
Product name
4-([1,1'-Biphenyl]-2-ylcarboxamido)benzoic acid
Purity
90%
Packaging
5g
Price
$683
Updated
2021/12/16
AK Scientific
Product number
5422AD
Product name
4-([1,1'-Biphenyl]-2-ylcarboxamido)benzoicacid
Packaging
5g
Price
$972
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0077932
Product name
4-[(BIPHENYL-2-CARBONYL)AMINO]BENZOIC ACID
Purity
95.00%
Packaging
5G
Price
$1501.5
Updated
2021/12/16
Crysdot
Product number
CD12134821
Product name
4-([1,1'-Biphenyl]-2-ylcarboxamido)benzoicacid
Purity
95+%
Packaging
1g
Price
$50
Updated
2021/12/16
Crysdot
Product number
CD12134821
Product name
4-([1,1'-Biphenyl]-2-ylcarboxamido)benzoicacid
Purity
95+%
Packaging
5g
Price
$150
Updated
2021/12/16
More
Less

4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid Chemical Properties,Usage,Production

Synthesis

Thionyl chloride (10.4 g, 87.4 mmol) was added to a mixture of biphenyl-2-carboxylic acid (15.0 g, 75.7 mmol) and DMF (0.28 g, 3.83 mmol) in toluene (72 mL) at an internal temperature of 40 ºC. The mixture was stirred at this temperature for approximately 2 h. After completion of the reaction, the mixture was concentrated to dryness at 60 ºC. The resultant residue was then diluted with toluene (36 mL) and concentrated to dryness at 60 ºC, and the process was repeated again to give biphenyl-2- carbonyl chloride as an oil. Acetone (100 mL) was added to the oil, and 4-amino benzoic acid (10.4 g, 75.8 mmol) and N,N-dimethylaniline (10.1 g, 83.3 mmol) were added to the resultant solution at 25 ºC. The mixture was stirred at this temperature for approximately 2 h. Water (100 mL) was then poured into the mixture, and it was stirred at 25 ºC for more than 1 h. The resultant crystals were collected by fifiltration and dissolved in DMF (100 mL) at 25 ºC. The solution was then fifiltered to remove insoluble materials, water (100 mL) was poured into the fifiltrate, and it was stirred at 25 ºC for approximately 2 h. The resultant crystals were collected by fifiltration and dried at 40 ºC to give the amide as white crystals (22.7 g, 95%).

Reference: Tsunoda, T.; Yamazaki, A.; Mase, T.; Sakamoto, S. Org. Process Res. Dev. 2005, 9, 593–598.

4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid Suppliers

China 88 France 1 United States 4 Global 93
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
More
Less

View Lastest Price from 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid manufacturers

Career Henan Chemical Co
Product
4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid 168626-74-2
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

168626-74-2, 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acidRelated Search:

Ammonium benzoate 4-(CHLOROSULFONYL)BENZOIC ACID 2-Methyl-4-(2-methylbenzamido)benzoic acid 2-Biphenylcarboxylic acid N-(4-(2-Methyl-5,6-dihydro-4H-benzo[b]oxazolo[5,4-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxaMide Conivaptan impurity 2-Methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine 2-Methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine Conivaptan hydrochloride 4-BROMO-1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE 2-Methyl-5,6-dihydro-4H-benzo[b]oxazolo[5,4-d]azepine 4-Aminobenzoic acid

  • 4-(2-Phenylbenzamido)benzoic acid
  • 4-[(2-Biphenylcarbonyl)amino]benzoic acid
  • Conivaptan impurity D
  • Conivaptan intermediate
  • Conivaptan-4
  • 4-[[oxo-(2-phenylphenyl)methyl]amino]benzoic acid
  • 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid
  • 4-([1,1'-Biphenyl]-2-ylcarboxamido)benzoic acid
  • 4-[([1,1'-Biphenyl]-2-carbonyl)aMino]benzoic Acid
  • Benzoic acid, 4-[([1,1'-biphenyl]-2-ylcarbonyl)aMino]-
  • Conivaptan hydrochloride Impurity D
  • 4-[([1,1'-biphenyl]-2-ylcarbonyl)amino]Benzoic acid
  • 4-[(2-phenylbenzoyl)amino]benzoic acid
  • 4-([1,1'-biphenyl]-2-carboxamido)benzoic acid
  • 4-[(biphenyl-2-carbonyl)amino]benzoic acid
  • Conivaptan Impurity 1
  • 3'-Formamido-[1,1':4',1''-terphenyl]-2-carboxylic acid
  • 4-[(2-Biphenylylcarbonyl)amino]benzoic acid
  • 168626-74-2