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Vilazodone Hydrochloride

Product Name
Vilazodone Hydrochloride
CAS No.
163521-08-2
Chemical Name
Vilazodone Hydrochloride
Synonyms
CS-796;EMD 68843;SB 659746A;Vilazodone HCl, >=98%;4-Methylenedioxyphenol;Vilazodone hydrochloride;Vilazodone HCl (EMD 68843;Vera trazodone hydrochloride;Vilazodone hydrochloride API;Vilazodone hydrochloride salt
CBNumber
CB72521214
Molecular Formula
C26H28ClN5O2
Formula Weight
477.98582
MOL File
163521-08-2.mol
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Vilazodone Hydrochloride Property

Melting point:
279°C(lit.)
Flash point:
9℃
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
color 
white to beige
Stability:
Hygroscopic
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Safety

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
7-16-36/37-45
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1098
Product name
Vilazodone hydrochloride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$70.8
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1098
Product name
Vilazodone hydrochloride
Purity
≥98% (HPLC)
Packaging
50mg
Price
$289
Updated
2024/03/01
TCI Chemical
Product number
V0149
Product name
Vilazodone Hydrochloride
Purity
>98.0%(HPLC)
Packaging
50mg
Price
$236
Updated
2024/03/01
TCI Chemical
Product number
V0149
Product name
Vilazodone Hydrochloride
Purity
>98.0%(HPLC)
Packaging
200mg
Price
$657
Updated
2024/03/01
Cayman Chemical
Product number
21547
Product name
Vilazodone (hydrochloride)
Purity
≥95%
Packaging
50mg
Price
$93
Updated
2024/03/01
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Vilazodone Hydrochloride Chemical Properties,Usage,Production

Description

Vilazodone is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A (IC50s = 0.2 and 0.5 nM, respectively). It increases extracellular 5-HT in the rat ventral hippocampus and frontal cortex when administered intraperitoneally at doses of 1 and 3 mg/kg. Vilazodone (1 mg/kg, i.p.) decreases immobility in the forced swim test in both rats and mice. Formulations containing vilazodone have been used in the treatment of depression.

Uses

Vilazodone Hydrochloride, is the salt form of Vilazodone (V265000), which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. Antidepressant.

Definition

ChEBI: A hydrochloride obtained by reaction of vilazodone with one equivalent of hydrochloric acid. Used for the treatment of major depressive disorder.

Clinical Use

Althoughseveral synthetic approaches have beenreported,a process-scale synthesis of vilazodone consists of the union of an indole-containing butyl tosylate 284 with a benzofuranyl piperazine whose synthesis is described in the scheme below. Piperazine 280 arises from a Buchwald coupling of commercially available benzofuranyl bromide 279 with piperazine through the use of a unique catalyst system employing the DavePhos ligand. This single coupling step, which has been executed on multigram scale in 70% yield,210 circumvented the need for any protecting group chemistry for either the primary amide within 279 or the piperazine amine functionality. For the preparation of the key indole subunit, Friedel-Crafts acylation of commercially available 5-cyanoindole (281) proceeded in good yield at the 3-position of the indole with 4-chlorobutanoyl chloride in 82% yield. Treatment of the resulting chloroketone with sodium borohydride in refluxing isopropanol converted 282 to the corresponding terminal alcohol 283. Tosylation of this alcohol was followed by displacement with piperazine 280 to give vilazodone hydrochloride (XXV) after acidification.

Synthesis

Vilazodone hydrochloride is a combined serotonin reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist marketed under the trade name Viibryd.202 Viibryd was developed by Merck KGaA (Germany) and approved for the treatment of depression by the U.S. FDA on January 21st, 2011. Vilazodone has been shown to be well-tolerated at higher dosage levels, specifically by not causing significant weight gain or decreased sexual desire or function, which are improvements over existing antidepressant treatments.

storage

Store at -20°C

Vilazodone Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Vilazodone Hydrochloride Suppliers

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View Lastest Price from Vilazodone Hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Vilazodone Hydrochloride 163521-08-2
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-09
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Vilazodone Hydrochloride 163521-08-2
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-10-09
Hebei Best Biological Technology Co., Ltd
Product
Vilazodone Hydrochloride 163521-08-2
Price
US $200.00/g
Min. Order
10g
Purity
99%
Supply Ability
1000t/month
Release date
2022-11-30

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  • Vilazodone HydrochlorideQ: What is Vilazodone Hydrochloride Q: What is the CAS Number of Vilazodone Hydrochloride Q: What is the storage condition of Vilazodone Hydrochloride Q: What are the applications of Vilazodone Hydrochloride
  • 4-Methylenedioxyphenol
  • 2H8]-Vilazodone hydrochloride salt
  • 163521-08-2
  • C26H27N5O2HCl
  • C26H28ClN5O2
  • C26H27N5O2ClH
  • API
  • Inhibitors