NVP-BHG712

Product Name: NVP-BHG712
CAS No.: 940310-85-0
Chemical Name: NVP-BHG712
Synonyms: CS-688;CS-475;NSC5175;NSC 5175;NSC-5175;NVP-BHG712;NVP-BHG712 ，S2202;NVP-BHG712 (BHG712);NVP-BHG712 USP/EP/BP;NVP-BHG 712; NVP BHG 712
CBNumber: CB72522978
Molecular Formula: C26H20F3N7O
Formula Weight: 503.48
MOL File: 940310-85-0.mol

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NVP-BHG712 Property

Density: 1.41
storage temp.: -20°C
solubility: DMSO: >15mg/mL
form: powder
pka: 13.20±0.70(Predicted)
color: white to beige

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HS Code: 2933.59.7000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0333
Product name: NVP-BHG 712
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $153.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0333
Product name: NVP-BHG 712
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $680
Updated: 2025/07/31

TCI Chemical

Product number: N1099
Product name: NVP-BHG 712
Purity: >95.0%(HPLC)
Packaging: 50mg
Price: $410
Updated: 2025/07/31

TCI Chemical

Product number: N1099
Product name: NVP-BHG 712
Purity: >95.0%(HPLC)
Packaging: 10mg
Price: $146
Updated: 2022/04/27

Cayman Chemical

Product number: 18489
Product name: NVP-BHG 712
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

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NVP-BHG712 Chemical Properties,Usage,Production

Uses

NVP-BHG712 is a small molecule specific EphB4, VEGFR2, c-raf, c-src and c-Abl kinase inhibitor with ED50 of 25 nM, 4.2, 0.4, 1.3 and 1.7μM, respectively.

Uses

NVP-BHG712 can be used in biological study and therapeutic use of combinations of kinase inhibitors for treating colorectal cancer.

Definition

ChEBI: 4-methyl-3-[[1-methyl-6-(3-pyridinyl)-4-pyrazolo[3,4-d]pyrimidinyl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide is a member of benzamides.

Biochem/physiol Actions

NVP-BHG712 is a very potent, selective inhbitor of the receptor tyrosine kinase EphB4 (ED50 = 25 nM). NVP-BHG712 blocks Ephrin receptor autophosphorylation and VEGF-induced angiogenesis.

in vivo

NVP-BHG712 (3, 10 and 30 mg/kg, p.o., daily) inhibits VEGF driven tissue growth and angiogenesis^[2].

Animal Model:	Mice arrying chambers^[1].
Dosage:	3, 10 and 30 mg/kg.
Administration:	P.O. daily for 4 days.
Result:	Significantly inhibited VEGF stimulated tissue formation and vascularization at doses of daily 3 mg/kg. Administration of 10 mg/kg/kg p.o. was sufficient to reverse VEGF enhanced tissue formation and vessel growth.

References

[1]. martiny-baron, g., et al., the small molecule specific ephb4 kinase inhibitor nvp-bhg712 inhibits vegf driven angiogenesis. angiogenesis, 2010. 13(3): p. 259-67.
[2]. kathawala, r.j., et al., the small molecule tyrosine kinase inhibitor nvp-bhg712 antagonizes abcc10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study. oncotarget, 2015. 6(1): p. 510-21.
[3]. becerikli, m., et al., ephb4 tyrosine-kinase receptor expression and biological significance in soft tissue sarcoma. int j cancer, 2015. 136(8): p. 1781-91.

NVP-BHG712 Preparation Products And Raw materials

Raw materials

Preparation Products

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NVP-BHG712 Suppliers

Americas 1 China 122 Europe 1 India 1 Japan 1 United States 19 Global 145

AdooQ BioScience, LLC

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940310-85-0, NVP-BHG712Related Search:

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NVP-BHG712

4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide

4-methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide

NVP-BHG712 4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide

4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluorome

NVP-BHG 712; NVP BHG 712

CS-475

CS-688

Benzamide, 4-methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]-

NVP-BHG712 USP/EP/BP

NVP-BHG712 (BHG712)

NSC 5175

NSC5175

NSC-5175

NVP-BHG712, 10 mM in DMSO

NVP-BHG712 ，S2202

940310-85-0

C26H20F3N7O

Inhibitors