[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone

Product Name: [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
CAS No.: 1000669-72-6
Chemical Name: [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
Synonyms: CS-468;KW 2449;KW-2449 100MG;KW2449;KW 2449;KW-2449 ，S2158;KW-2449, 10 mM in DMSO;KW-2449;KW 2449; KW2449;KW-2449 hydrochloride HCL;[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone;(4-(2-(1H-Indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone
CBNumber: CB72554360
Molecular Formula: C20H20N4O
Formula Weight: 332.4
MOL File: 1000669-72-6.mol

More

Less

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Property

Boiling point:: 604.1±55.0 °C(Predicted)
Density: 1.28
storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
pka: 13.76±0.40(Predicted)
form: solid
color: Pale yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 22207
Product name: KW 2449
Purity: ≥98%
Packaging: 5mg
Price: $35
Updated: 2024/03/01

Cayman Chemical

Product number: 22207
Product name: KW 2449
Purity: ≥98%
Packaging: 10mg
Price: $67
Updated: 2024/03/01

Cayman Chemical

Product number: 22207
Product name: KW 2449
Purity: ≥98%
Packaging: 25mg
Price: $149
Updated: 2024/03/01

Cayman Chemical

Product number: 22207
Product name: KW 2449
Purity: ≥98%
Packaging: 50mg
Price: $263
Updated: 2024/03/01

AK Scientific

Product number: X7371
Product name: (E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone
Packaging: 50mg
Price: $290
Updated: 2021/12/16

More

Less

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Chemical Properties,Usage,Production

Description

KW-2449 is a potent multikinase inhibitor (IC50’s: FLT3 = 7 nM, FGFR1 = 36 nM, Abl = 14 nM, Abl-T315 = 4 nM) with anti-leukemic effects.1,2,3

Uses

KW-2449 is a multi-targeted kinase inhibitor of FLT3, ABL, ABLT315I and Aurora kinase with IC50s of 6.6, 14, 4 and 48 nM, respectively.

Definition

ChEBI: [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone is a member of indazoles.

in vivo

Oral administration of KW-2449 shows dose-dependent and significant tumor growth inhibition in FLT3-mutated xenograft model with minimum bone marrow suppression. In FLT3 wild-type human leukemia, it induces the reduction of phosphorylated histone H3, G2/M arrest, and apoptosis. In imatinib-resistant leukemia, KW-2449 contributes to release of the resistance by the simultaneous down-regulation of BCR/ABL and Aurora kinases. Furthermore, the antiproliferative activity of KW-2449 is confirmed in primary samples from AML and imatinib-resistant patients. The inhibitory activity of KW-2449 is not affected by the presence of human plasma protein, such as α1-acid glycoprotein^[1].

target

FLT3

IC 50

Abl: 4 nM (IC₅₀); ABL-T315I: 14 nM (IC₅₀); FGFR1: 36 nM (IC₅₀); Aurora A: 48 nM (IC₅₀); FLT3/D835Y: 1 nM (IC₅₀); FLT3: 6.6 nM (IC₅₀); JAK2: 150 nM (IC₅₀); SRC: 400 nM (IC₅₀); PDFGRα: 1700 nM (IC₅₀)

References

[1] Y. SHIOTSU. KW-2449, a Novel Multi-Kinase Inhibitor Against FLT3, Abl, FGFR1 and Aurora, Suppresses the Growth of AML Both In Vitro and In Vivo .[J]. Blood, 2007, 110 1: 1832-1832. DOI:10.1182/blood.v110.11.1832.1832
[2] KW-2449, a Novel Multi-Kinase Inhibitor, suppresses the growth of leukemia cells with FLTY3 mutations or T315l-mutated BCR/ABL translocation
[3] KEITH W PRATZ. A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response.[J]. Blood, 2009, 113 17: 3938-3946. DOI:10.1182/blood-2008-09-177030

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Suppliers

China 119 France 1 India 1 United States 18 Global 139

Alsachim SAS

Tel: --
Fax: --
Email: sales@alsachim.com
Country: France
ProdList: 424
Advantage: 0

More

Less

View Lastest Price from [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone manufacturers

Career Henan Chemical Co

Product: [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone 1000669-72-6
Price: US $2000.00-1950.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100kg
Release date: 2018-08-04

1000669-72-6, [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanoneRelated Search:

TYRPHOSTIN AG 1296 (+)-Camptothecin (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT SU 4312 FLUSULFAMIDE MK-2206 2HCl Dasatinib Entinostat Veliparib Ibrutinib 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone

KW 2449

(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone

KW2449(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanonehydrochloride

KW-2449;KW 2449; KW2449

[4-[(E)-2-(1H-indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone

KW-2449 100MG

{4-[(E)-2-(1H-Indazol-3-yl)vinyl]phenyl}(1-piperazinyl)methanone

3-[(E)-2-{4-[(PIPERAZIN-1-YL)CARBONYL]PHENYL}ETHENYL]-2H-INDAZOLE

KW2449;KW 2449

CS-468

Methanone, [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-1-piperazinyl-

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone USP/EP/BP

KW-2449 hydrochloride HCL

(4-(2-(1H-Indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone

KW-2449, 10 mM in DMSO

KW-2449 ，S2158

1000669-72-6

Inhibitors

Inhibitor