[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
- Product Name
- [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
- CAS No.
- 1000669-72-6
- Chemical Name
- [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
- Synonyms
- CS-468;KW 2449;KW-2449 100MG;KW2449;KW 2449;KW-2449;KW 2449; KW2449;KW-2449 hydrochloride HCL;[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone;{4-[(E)-2-(1H-Indazol-3-yl)vinyl]phenyl}(1-piperazinyl)methanone;Methanone, [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-1-piperazinyl-;3-[(E)-2-{4-[(PIPERAZIN-1-YL)CARBONYL]PHENYL}ETHENYL]-2H-INDAZOLE
- CBNumber
- CB72554360
- Molecular Formula
- C20H20N4O
- Formula Weight
- 332.4
- MOL File
- 1000669-72-6.mol
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Property
- Boiling point:
- 604.1±55.0 °C(Predicted)
- Density
- 1.28
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (>25 mg/ml)
- pka
- 13.76±0.40(Predicted)
- form
- solid
- color
- Pale yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 22207
- Product name
- KW 2449
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $35
- Updated
- 2024/03/01
- Product number
- 22207
- Product name
- KW 2449
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $67
- Updated
- 2024/03/01
- Product number
- 22207
- Product name
- KW 2449
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $149
- Updated
- 2024/03/01
- Product number
- 22207
- Product name
- KW 2449
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $263
- Updated
- 2024/03/01
- Product number
- X7371
- Product name
- (E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone
- Packaging
- 50mg
- Price
- $290
- Updated
- 2021/12/16
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Chemical Properties,Usage,Production
Description
KW-2449 is a potent multikinase inhibitor (IC50’s: FLT3 = 7 nM, FGFR1 = 36 nM, Abl = 14 nM, Abl-T315 = 4 nM) with anti-leukemic effects.1,2,3
Definition
ChEBI: [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone is a member of indazoles.
target
FLT3
References
Shiotsu et al. (2007) KW-2449, a Novel Multi-Kinase Inhibitor Against FLT3, Abl, FGFR1, and Aurora, Suppresses the Growth of AML Both In Vitro and In Vivo; Blood; 110 1832 Shiotsu et al. (2009) KW-2449, a Novel Multi-Kinase Inhibitor, suppresses the growth of leukemia cells with FLTY3 mutations or T315l-mutated BCR/ABL translocation; Blood; 114 1607 Pratz et al. (2009) A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response; Blood; 113 3938
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Preparation Products And Raw materials
Raw materials
Preparation Products
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Suppliers
View Lastest Price from [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone manufacturers
- Product
- [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone 1000669-72-6
- Price
- US $2000.00-1950.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2018-08-04