Methyl 6-(hydroxymethyl)nicotinate

Product Name: Methyl 6-(hydroxymethyl)nicotinate
CAS No.: 56026-36-9
Chemical Name: Methyl 6-(hydroxymethyl)nicotinate
Synonyms: ethyl 6-(hydroxyMethyl)nicotinate;6-Hydroxymethyl-Nicotinic;METHYL 6-(HYDROXYMETHYL)NICOTINATE;methyl 6-(hydroxymethyl)nicotinate (en);6-HYDROXYMETHYL-NICOTINIC ACID METHYL ESTER;Methyl 2-(hydroxyMethyl)pyridine-5-carboxylate;Methyl 6-(hydroxyMethyl)pyridine-3-carboxylate;6-(Hydroxymethyl)pyridine-3-carboxylate Methyl Ester;3-Pyridinecarboxylicacid, 6-(hydroxymethyl)-, methyl ester;6-(hydroxymethyl)-3-Pyridinecarboxylic acid methyl ester (9CI ACI)
CBNumber: CB7255885
Molecular Formula: C8H9NO3
Formula Weight: 167.16
MOL File: 56026-36-9.mol

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Methyl 6-(hydroxymethyl)nicotinate Property

Melting point:: 75-78℃
Boiling point:: 293.4±30.0 °C(Predicted)
Density: 1.244±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
pka: 13.20±0.10(Predicted)
color: White to Orange to Green
InChI: InChI=1S/C8H9NO3/c1-12-8(11)6-2-3-7(5-10)9-4-6/h2-4,10H,5H2,1H3
InChIKey: QVLONHSXRWCCAE-UHFFFAOYSA-N
SMILES: C1=NC(CO)=CC=C1C(OC)=O
CAS DataBase Reference: 56026-36-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000411
Product name: 6-Hydroxymethyl-nicotinic acid methyl ester
Purity: Aldrich
Packaging: 1g
Price: $463
Updated: 2023/01/07

TCI Chemical

Product number: M2750
Product name: Methyl 6-(Hydroxymethyl)nicotinate
Purity: >97.0%(GC)(T)
Packaging: 200mg
Price: $71
Updated: 2025/07/31

TCI Chemical

Product number: M2750
Product name: Methyl 6-(Hydroxymethyl)nicotinate
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $212
Updated: 2025/07/31

TRC

Product number: M323495
Product name: Methyl 6-(Hydroxymethyl)nicotinate
Packaging: 1g
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 026191
Product name: Methyl 6-(hydroxymethyl)nicotinate
Purity: 98%
Packaging: 1g
Price: $33
Updated: 2021/12/16

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Methyl 6-(hydroxymethyl)nicotinate Chemical Properties,Usage,Production

Synthesis

881-86-7

56026-36-9

Step 1. Synthesis of methyl 6-(hydroxymethyl)nicotinate (55): a mixture of methyl 2,5-pyridinedicarboxylate (54; 100.0 g, 0.51 mol), CaCl2 (227.4 g, 2.05 mol), and THF (1100 mL) was mixed with EtOH (1200 mL), and stirred for 30 min. NaBH4 (48.6 g, 1.28 mol) was added in batches at 0 °C. The reaction mixture was stirred at room temperature for 18 hours. Subsequently, saturated NH4Cl solution (1.5 L) and water (2.0 L) were added slowly and extracted with dichloromethane (3 x 3.0 L). The organic phases were combined, dried with MgSO4 and concentrated under reduced pressure to give methyl 6-(hydroxymethyl)nicotinate 55 (82.0 g, 96% yield).

References

[1] Patent: WO2010/56549, 2010, A1. Location in patent: Page/Page column 103
[2] Journal of Organic Chemistry, 2010, vol. 75, # 3, p. 650 - 659
[3] Inorganic Chemistry, 2015, vol. 54, # 22, p. 10542 - 10558
[4] Patent: US2010/16373, 2010, A1. Location in patent: Page/Page column 16
[5] Patent: US2016/256578, 2016, A1. Location in patent: Paragraph 0124; 0125

Methyl 6-(hydroxymethyl)nicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 6-(hydroxymethyl)nicotinate Suppliers

Americas 1 China 173 Europe 1 India 7 Japan 1 United Kingdom 4 United States 19 Global 206

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View Lastest Price from Methyl 6-(hydroxymethyl)nicotinate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Methyl 6-(hydroxymethyl)nicotinate 56026-36-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100kg
Release date: 2025-09-29

Career Henan Chemical Co

Product: Methyl 6-(hydroxymethyl)nicotinate 56026-36-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: Customized
Release date: 2018-12-14

56026-36-9, Methyl 6-(hydroxymethyl)nicotinateRelated Search:

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6-HYDROXYMETHYL-NICOTINIC ACID METHYL ESTER

METHYL 6-(HYDROXYMETHYL)NICOTINATE

6-Hydroxymethyl-Nicotinic

methyl 6-(hydroxymethyl)nicotinate (en)

ethyl 6-(hydroxyMethyl)nicotinate

Methyl 6-(hydroxyMethyl)pyridine-3-carboxylate

3-Pyridinecarboxylicacid, 6-(hydroxymethyl)-, methyl ester

Methyl 2-(hydroxyMethyl)pyridine-5-carboxylate

6-(Hydroxymethyl)pyridine-3-carboxylate Methyl Ester

3-Pyridinecarboxylic acid, 6-(hydroxymethyl)-, methyl ester (9CI, ACI)

6-(hydroxymethyl)-3-Pyridinecarboxylic acid methyl ester (9CI ACI)

Methyl 6-(Hydroxymethyl)nicotinate, Methyl 6-(hydroxymethyl)nicotinate, 6-Hydroxymethyl-nicotinic acid methyl ester,6-Hydroxymethylnicotinate

56026-36-9

Esters

Pyridines