ChemicalBook > CAS DataBase List > 1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester

1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester

Product Name
1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester
CAS No.
144690-33-5
Chemical Name
1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester
Synonyms
OMSTINT-J;Olmesartan Medoxomil-19;Olmesartan ester impurity 28;Trityl olMesartan ethyl ester;Olmesartan Medoxomil Impurity 28;Olmesartan Medoxomil Impurity 31;Azilsartan medoxomil impurity229;OlMesartan Ethyl Ester Trityl IMpurity;5-(4'-(dibromomethyl)-[1,1'-biphenyl]-2-yl)-1H-tetrazole;1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-...
CBNumber
CB72570964
Molecular Formula
C45H44N6O3
Formula Weight
716.87
MOL File
144690-33-5.mol
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1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester Property

Melting point:
161℃
Boiling point:
889.7±75.0 °C(Predicted)
Density 
1.18±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
13.18±0.29(Predicted)
color 
White to Off-White
Water Solubility 
4.6μg/L at 25℃
LogP
9.64 at 25℃
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Safety

RIDADR 
UN1325
HazardClass 
4.1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
E945628
Product name
Ethyl4-(2-Hydroxypropan-2-yl)-2-propyl-1-((2''-(1-trityl-1H-tetrazol-5-yl)-[1,1''-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate
Packaging
5g
Price
$45
Updated
2021/12/16
TRC
Product number
E945628
Product name
Ethyl4-(2-Hydroxypropan-2-yl)-2-propyl-1-((2''-(1-trityl-1H-tetrazol-5-yl)-[1,1''-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate
Packaging
50g
Price
$175
Updated
2021/12/16
Biosynth Carbosynth
Product number
IH57930
Product name
4-(1-Hydroxy-1-methylethyl)-2-propyl-1[4-[2-(trityltetrazol-5-yl)phenyl]phenyl]methylimidazo-5-carboxylate ethyl
Packaging
250g
Price
$157.5
Updated
2021/12/16
Biosynth Carbosynth
Product number
IH57930
Product name
4-(1-Hydroxy-1-methylethyl)-2-propyl-1[4-[2-(trityltetrazol-5-yl)phenyl]phenyl]methylimidazo-5-carboxylate ethyl
Packaging
500g
Price
$250
Updated
2021/12/16
Biosynth Carbosynth
Product number
IH57930
Product name
4-(1-Hydroxy-1-methylethyl)-2-propyl-1[4-[2-(trityltetrazol-5-yl)phenyl]phenyl]methylimidazo-5-carboxylate ethyl
Packaging
50g
Price
$50
Updated
2021/12/16
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1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester Chemical Properties,Usage,Production

Uses

Tritylolmesartan Ethyl Ester is an impurity of olmesartan medoxomil (O550000), an angiotensin II receptor antagonist and anti-hypertensive drug.

Synthesis

76-83-5

144689-23-6

144690-33-5

To ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[4-[2-(tetrazol-5-yl)phenyl]phenyl]methylimidazole-5-carboxylate (BIH, 100 g, 1 eq.) was added dichloromethane (500 mL, 5 vol.), and stirred until completely dissolved. Triethylamine (32.3 mL, 1.1 eq.) was added and the reaction mixture was cooled to 0 °C - 5 °C. A solution of triphenylchloromethane (63.22 g, 1.08 eq.) in dichloromethane (300 mL, 3 vol.) was slowly added dropwise over 30 min at 0 °C-5 °C. After the dropwise addition was completed, the reaction mixture was warmed to 25°C-30°C with continuous stirring for 12 hours. Triphenylchloromethane (2.92 g, 0.05 eq.) was added additionally and stirring was continued for 3 hours. The reaction was monitored by thin layer chromatography (TLC, unfolding agent: 10% methanol/dichloromethane, UV detection) to confirm complete conversion of BIH. The reaction mixture was cooled to 0°C-5°C, demineralized water (270 mL, 2.7 v/v) was added, and stirred at 25°C-30°C for 15 min. Layers were left to separate and the aqueous phase was extracted with dichloromethane (200 mL, 2 volumes). The organic phases were combined and washed with deionized water (500 mL, 5 volumes). The organic phase was dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure at 40°C-45°C to afford ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[4-[2-(triphenylmethyltetrazol-5-yl)phenyl]phenyl]methylimidazole-5-carboxylate (BIT, 135 g, 89% yield).

References

[1] Patent: EP2891650, 2015, A1. Location in patent: Paragraph 0298-0300
[2] Patent: US2015/239854, 2015, A1. Location in patent: Page/Page column 39

1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester Suppliers

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View Lastest Price from 1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester 144690-33-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-29
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Olmesartan Medoxomil Impurity 31 144690-33-5
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-06-14
Career Henan Chemical Co
Product
1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester 144690-33-5
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-21

144690-33-5, 1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl esterRelated Search:

4,5-Bismethylene-1,3-dioxolan-2-one OlMesartan Lactone IMpurity Olmesartan Dehydro Olmesartan OlMesartan MedoxoMil Ethyl Methyl Analog 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole Trityl olMesartan acid Trityl olMesartan MedoxoMil iMpurity II OlMesartan Methyl Ester 5-[4’-Hydroxymethyl-(1,1’-biphenyl)-2-yl]-1-triphenylmethyltetrazole 4-Cloromethyl-5-methyl-1,3-dioxol-2-one Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate 2,2'-(2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-4,5-diyl)bis(propan-2-ol) 3,6-Dihydro-6,6-diMethyl-2-propyl-3-[[2'-[2-(triphenylMethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-4H-furo[3,4-d]iMidazol-4-one OlMesartan MedoxoMil iMpurity V N-Trityl Olmesartan Ethyl Ester 4-(1-Methoxy-1-methylethyl)-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester Diethyl 2-propylImidazoledicarbonate

  • 1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester
  • Trityl olMesartan ethyl ester
  • OlMesartan Ethyl Ester Trityl IMpurity
  • 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid ethyl ester
  • 1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1
  • Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate
  • OMSTINT-J
  • Olmesartan Medoxomil-19
  • Ethyl 4-(2-hydroxy-2-propanyl)-2-propyl-1-{[2'-(1-trityl-1H-tetra zol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylate
  • Olmesartan Medoxomil Impurity 31
  • Olmesartan Medoxomil Impurity 28
  • 5-(4'-(dibromomethyl)-[1,1'-biphenyl]-2-yl)-1H-tetrazole
  • Olmesartan Medoxomil impurity 2/Olmesartan Ethyl Ester Trityl Impurity/Ethyl 4-(2-Hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate
  • 4-(1-Hydroxy-1-methylethyl)-2-propyl-1[4-[2-(trityltetrazol-5-yl)phenyl]phenyl]methylimidazo-5-carboxylate ethyl
  • 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol
  • 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-...
  • Azilsartan medoxomil impurity229
  • Olmesartan ester impurity 28
  • Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-(2(2-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)ethyl)-1H-imidazole-5-carboxylate
  • Olmesartan Ethyl Ester Trityl Impurity 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2- propyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'- biphenyl]-4-yl]methyl]-, ethyl ester' Ethyl 4-(1-hydroxy-1- methylethyl)-2-propyl-1-[4-[2-(trityltetrazol-5-
  • 2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester
  • Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate (Olmesartan Medoxomi Impurity)
  • Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate
  • 1H-imidazole-5-carboxylic acid, 2-propyl-4-(1-hydroxy-1-methylethyl)-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-,ethyl ester
  • 144690-33-5