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Palonosetron

Product Name
Palonosetron
CAS No.
135729-56-5
Chemical Name
Palonosetron
Synonyms
PALMATINE(P);RS 25233-198;Palonosteron;Unii-5D06587D6r;(S)-2-(1-Azabicyclo[2.2.2]oct-3-yl)-2,4,5,6-tetrahydro-1H-benz[de]isoquinolin-1-one;1H-Benz[de]isoquinolin-1-one, 2-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,4,5,6-tetrahydro-;(3AS)-2-(S)-1-AZABICYCLO[2,2,2]OCT-3-YL)-2,3,3A,4,5,6-HEXAHYDRO-1H-BENZ(D)ISOQUINOLIN-1-ONE;(3AS)-2-[(3S)-1-AZABICYCLO[2.2.2]OCT-3-YL]-2,3,3A,4,5,6-HEXAHYDRO-1H-BENZ[DE]ISOQUINOLIN-1-ONE;Palonosetron (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one
CBNumber
CB7257940
Molecular Formula
C19H22N2O
Formula Weight
294.39
MOL File
135729-56-5.mol
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Palonosetron Property

Boiling point:
511.0±50.0 °C(Predicted)
Density 
1.24
pka
9.77±0.33(Predicted)
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Hazard and Precautionary Statements (GHS)

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Palonosetron Chemical Properties,Usage,Production

Uses

Palonosetron can be used to Anti-emetic; antinauseant.

brand name

Aloxi (Helsinn).

in vivo

In anesthetized rats, Dehydro Palonosetron (RS 42358-197), administered by the intravenous, intraduodenal or transdermal route, dose-dependently inhibited the Bezold-Jarisch reflex induced by 2-methyl 5-HT (ID50:0.05 μg/kg; i.v., 5.7 μg/kg; i.d., and 11.6 μg/chamber, respectively)[1].
Dehydro Palonosetron (RS 42358-197; 0.01 ng/kg-10 mg/kg; oral administration; once) disinhibits behaviour in the mouse suppressed by the aversive situation of the light/dark test box[2].

Animal Model:Male albino BKW mice (30-35 g)[2]
Dosage:0.01 ng/kg, 0.1 ng/kg, 1 ng/kg, 100 ng/kg, 1 μg/kg, 100 μg/kg, 1 mg/kg, 10 mg/kg
Administration: Oral administration; once
Result:Increased the proportion of time mice spent and the number of rearings and line crossings in the light area of the test chamber.

IC 50

5-HT3 Receptor

Palonosetron Preparation Products And Raw materials

Raw materials

Preparation Products

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Palonosetron Suppliers

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View Lastest Price from Palonosetron manufacturers

Career Henan Chemical Co
Product
Palonosetron 135729-56-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kgs
Release date
2020-01-28

135729-56-5, PalonosetronRelated Search:

Tropisetron (S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-5,6,7,8-tetrahydro-1-naphthalenecarboxamide PALMATINE CHLORIDE HYDRATE Palmatine HCL,PALMATINE HYDROCHLORIDE,PALMATINE CHLORIDE PALMATINE,PALMATINE, 98% BY HPLC Palonosetron Hydrochloride Palonosetron 2-(piperidin-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline N-METHYL-N-(PHENYLMETHYL)-4-PIPERIDINEMETHANAMINE N-METHYL-N-(4-PIPERIDINYLMETHYL)-ACETAMIDE Palmatine chloride std.,PALMATINE CHLORIDE(RG) PALMATINE(P) PALMATINE IODIDE PALMATINE CHLORID (S)-(S)-2-(1-AZA-BICYCLO[2.2.2]OCT-3-YL)-2,3,3A,4,5,6-HEXAHYDRO-BENZO[DE]ISOQUINOLIN-1-ONE N-METHYL-N-(4-PIPERIDINYLMETHYL)-BENZAMIDE 1,8-DIMETHYLTETRALINE N-METHYL-N-(2-PHENYLETHYL)-4-PIPERIDINEMETHANAMINE

  • Palonosteron
  • RS 25233-198
  • PALMATINE(P)
  • (3AS)-2-(S)-1-AZABICYCLO[2,2,2]OCT-3-YL)-2,3,3A,4,5,6-HEXAHYDRO-1H-BENZ(D)ISOQUINOLIN-1-ONE
  • (S)-2-(1-Azabicyclo[2.2.2]oct-3-yl)-2,4,5,6-tetrahydro-1H-benz[de]isoquinolin-1-one
  • Unii-5D06587D6r
  • Palonosetron (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one
  • (3AS)-2-[(3S)-1-AZABICYCLO[2.2.2]OCT-3-YL]-2,3,3A,4,5,6-HEXAHYDRO-1H-BENZ[DE]ISOQUINOLIN-1-ONE
  • 1H-Benz[de]isoquinolin-1-one, 2-(3S)-1-azabicyclo[2.2.2]oct-3-yl-2,4,5,6-tetrahydro-
  • 135729-56-5