N-BOC-6-azaspiro[3.4]octan-2-ol
- Product Name
- N-BOC-6-azaspiro[3.4]octan-2-ol
- CAS No.
- 1239319-91-5
- Chemical Name
- N-BOC-6-azaspiro[3.4]octan-2-ol
- Synonyms
- N-BOC-6-azaspiro[3.4]octan-2-ol;6-Boc-6-azaspiro[3.4]octan-2-ol;N-Boc-2-hydroxy-6-aza-spiro[3.4]octane;6-Boc-2-hydroxy-6-aza-spiro[3.4]octane;tert-Butyl 2-Hydroxy-6-azaspiro[3.4]octane-6-carboxylate;tert-butyl 2-(tosyloxy)-6-azaspiro[3.4]octane-6-carboxylate;6-Azaspiro[3.4]octane-6-carboxylic acid, 2-hydroxy-, 1,1-dim...;2-Hydroxy-6-azaspiro[3.4]octane-6-carboxylic acid 1,1-dimethylethyl ester;6-Azaspiro[3.4]octane-6-carboxylic acid, 2-hydroxy-, 1,1-dimethylethyl ester;6-Azaspiro[3.4]octane-6-carboxylic acid, 2-hydroxy-, 1,1-dimethylethyl ester - A7189
- CBNumber
- CB72582875
- Molecular Formula
- C12H21NO3
- Formula Weight
- 227.3
- MOL File
- 1239319-91-5.mol
N-BOC-6-azaspiro[3.4]octan-2-ol Property
- Boiling point:
- 338℃
- Density
- 1.14
- Flash point:
- 156℃
- storage temp.
- 2-8°C
- pka
- 14.97±0.20(Predicted)
- Appearance
- White to light yellow Solid-liquid mixture
- InChI
- InChI=1S/C12H21NO3/c1-11(2,3)16-10(15)13-5-4-12(8-13)6-9(14)7-12/h9,14H,4-8H2,1-3H3
- InChIKey
- KAVBYCOMZDNOFX-UHFFFAOYSA-N
- SMILES
- C1C2(CCN(C(OC(C)(C)C)=O)C2)CC1O
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B701763
- Product name
- tert-Butyl2-Hydroxy-6-azaspiro[3.4]octane-6-carboxylate
- Packaging
- 1g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 4H56-1-158
- Product name
- 6-Boc-2-hydroxy-6-azaspiro[3.4]octane
- Packaging
- 1g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 35870
- Product name
- tert-Butyl2-hydroxy-6-azaspiro[3.4]octane-6-carboxylate
- Purity
- 95%
- Packaging
- 100mg
- Price
- $545
- Updated
- 2021/12/16
- Product number
- A7189
- Product name
- 6-Azaspiro[3.4]octane-6-carboxylicacid,2-hydroxy-,1,1-dimethylethylester
- Purity
- 97.0%
- Packaging
- 5g
- Price
- $640
- Updated
- 2021/12/16
- Product number
- CHM0393958
- Product name
- TERT-BUTYL-2-HYDROXY-6-AZASPIRO[3.4]OCTANE-6-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $731.85
- Updated
- 2021/12/16
N-BOC-6-azaspiro[3.4]octan-2-ol Chemical Properties,Usage,Production
Synthesis
203661-71-6
1239319-91-5
The general procedure for the synthesis of tert-butyl 2-hydroxy-6-azaspiro[3.4]octane-6-carboxylate using 6-Boc-2-oxo-6-azaspiro[3.4]octane as starting material was as follows: to a solution of 6-Boc-2-oxo-6-azaspiro[3.4]octane (19 g, 84.3 mmol) in tetrahydrofuran (THF, 200 mL) at 0 °C, slowly sodium borohydride (NaBH4, 12.8 g, 337.2 mmol) was added. After addition, the reaction mixture was gradually warmed up to ambient temperature and stirred continuously for 6 hours. Upon completion of the reaction, the reaction was quenched with methanol (MeOH) and water (H2O), followed by extraction with ethyl acetate (EtOAc). The organic layers were combined, washed with saturated saline (brine), dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The crude product was purified by fast column chromatography (silica gel (SiO2) as stationary phase and petroleum ether solution of petroleum ether (Hep) to 50% ethyl acetate (EtOAc) as eluent) to afford the target product tert-butyl 2-hydroxy-6-azaspiro[3.4]octane-6-carboxylate (R-6, 12 g, 63% yield).
References
[1] Patent: US2014/45813, 2014, A1. Location in patent: Paragraph 0114
[2] Patent: US2014/275014, 2014, A1. Location in patent: Paragraph 0128; 0129; 0133
[3] Patent: WO2015/116485, 2015, A1. Location in patent: Page/Page column 24; 25
[4] Patent: US2011/319381, 2011, A1. Location in patent: Page/Page column 10
[5] Patent: US2012/129830, 2012, A1. Location in patent: Page/Page column 10
N-BOC-6-azaspiro[3.4]octan-2-ol Preparation Products And Raw materials
Raw materials
Preparation Products
N-BOC-6-azaspiro[3.4]octan-2-ol Suppliers
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- 021-021-58432009 400-005-6266
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- +86-21-34975602-805
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- 021-60455363 18019463053
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View Lastest Price from N-BOC-6-azaspiro[3.4]octan-2-ol manufacturers
- Product
- N-BOC-6-azaspiro[3.4]octan-2-ol 1239319-91-5
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g； 1kg; 25kg
- Release date
- 2020-01-10