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CP-456773 sodium

Product Name
CP-456773 sodium
CAS No.
256373-96-3
Chemical Name
CP-456773 sodium
Synonyms
MCC950 sodium;8-DHF;CPD1600;Crid3 sodium;CP45677 sodium;CP 45677 sodium;CP-45677 sodium;NLRP3 Inhibitor;CP-456773 sodium;CRID3 sodium salt
CBNumber
CB63119754
Molecular Formula
C20H23N2NaO5S
Formula Weight
426.46179
MOL File
256373-96-3.mol
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CP-456773 sodium Property

storage temp. 
room temp
solubility 
Soluble in DMSO:50.0(Max Conc. mg/mL);117.24(Max Conc. mM)
Water:30.0(Max Conc. mg/mL);70.35(Max Conc. mM)
form 
powder
color 
white to beige
Water Solubility 
water: 1mg/mL
DMSO: 50mg/mL
InChI
InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1
InChIKey
LFQQNXFKPNZRFT-UHFFFAOYSA-M
SMILES
O=C(NC1C2CCCC=2C=C2CCCC=12)[N-]S(=O)(=O)C1OC=C(C(C)(O)C)C=1.[Na+]
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Safety

HS Code 
2932990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.38120
Product name
NLRP3 Inhibitor, MCC950 - CAS 256373-96-3 - Calbiochem
Purity
A cell-potent, bioavailable NLRP3 inflammasome activation inhibitor. Effectively blocks caspase-1 & -11 activation, IL-1β processing and IL-1β & IL-6 secretion.
Packaging
10MG
Price
$206
Updated
2025/07/31
Sigma-Aldrich
Product number
PZ0280
Product name
CP-456773 sodium salt
Purity
≥98% (HPLC)
Packaging
5mg
Price
$115
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0280
Product name
CP-456773 sodium salt
Purity
≥98% (HPLC)
Packaging
25mg
Price
$462
Updated
2024/03/01
TCI Chemical
Product number
M3396
Product name
MCC950 Sodium Salt
Packaging
10MG
Price
$141
Updated
2025/07/31
Tocris
Product number
5479
Product name
CRID3sodiumsalt
Purity
≥98%(HPLC)
Packaging
10
Price
$201
Updated
2021/12/16
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CP-456773 sodium Chemical Properties,Usage,Production

Uses

CP-456773 sodium salt has been used :

  • In in vivo experiments to study the neuroprotective action of ketogenic diet.
  • To study the effect of inhibition of NLRP3 (nod-like receptor protein 3) inflammasome activity on tumor progression in mouse models.
  • To study the cholesterol crystal-mediated IL-1b (interleukin-1b) response in placental explants.

Biochem/physiol Actions

CP-456773 is known to inhibit the release of other proinflammatory cytokines such as IL-1α and IL-18. It is also referred to as MCC950.

in vivo

MCC950 reduces Interleukin-1p (IL-1β) production and attenuates the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis. Pre-treatment with MCC950 reduces serum concentrations of IL-1β and IL-6 while it does not considerably decrease the amount of TNF-α. Treatment of mice with MCC950 delays the onset and reduced the severity of EAE. Intracellular cytokine staining and FACS analysis of brain mononuclear cells from mice sacrificed on day 22 shows modestly reduced frequencies of IL-17 and IFN-γ producing CD3+ T cells in MCC950 treated mice in comparison with PBS-treated mice. IFN-γ and particularly IL-17 producing cell numbers are also reduced in both the CD4+ and γδ+ sub-populations of CD3+ T cells[1].

IC 50

NLRP3

storage

+4°C

CP-456773 sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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CP-456773 sodium Suppliers

China 152 India 1 United Kingdom 2 United States 12 Global 167
Hunan Huayi Zhide Pharmaceutical Technology Co., Ltd.
Tel
17752881701
Email
190060276@qq.com
Country
China
ProdList
170
Advantage
58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.
Tel
15387063101
Email
2881924050@qq.com
Country
China
ProdList
9960
Advantage
58
Biokitchen
Tel
021-021-021-31663258 13795219287
Fax
021-31663258
Email
donghuanwen@126.com
Country
China
ProdList
8816
Advantage
58
Chengdu Celes Technology Co., Ltd
Tel
19982073091
Email
2538834896@qq.com
Country
China
ProdList
77
Advantage
58
Deyang Sino Biotech. Co., LTD
Tel
+86-19182167371 +86-19182167371;
Email
service@synlord.com
Country
China
ProdList
110
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9400
Advantage
55
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
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View Lastest Price from CP-456773 sodium manufacturers

Career Henan Chemical Co
Product
CP-456773 sodium 256373-96-3
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
200kg
Release date
2020-03-05

256373-96-3, CP-456773 sodiumRelated Search:

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  • MCC950 sodium (CP-456773 sodium
  • CP-456773 SODIUM; CRID3 SODIUM SALT; MCC-950 SODIUM; CP456773 SODIUM; CRID-3 SODIUM SALT
  • N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt
  • MCC950 (CP-456773) sodium
  • CP-456773 sodium
  • MCC950 sodium
  • CP-456773 sodium salt
  • N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide monosodium salt
  • MCC950(CP-456773)
  • CRID3 sodium salt
  • MCC-950 Sodium, CP-456773
  • CPD1600
  • sodium salt of 1-(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)-3-[4-(1-hydroxy-1-methyl-ethyl)-furan-2-sulfonyl]-urea
  • MCC 950 sodium NEW
  • MCC950 sodium salt
  • MCC950 Sodium Salt (CP-456773)
  • CP-456773 sodium salt >=98% (HPLC)
  • Crid3 sodium
  • N-(1,2,3,5,6,7-Hexahydro-s-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide Sodium
  • Sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)((4-(2-hydroxypropan-2-yl)furan-2-yl)sulfonyl)amide
  • 8-DHF
  • 2-Furansulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-, sodium salt (1:1)
  • CP 456773,MCC-950 sodium,MCC-950,inhibit,Inhibitor,CP456773,NOD-like Receptor (NLR),CRID3,MCC950 sodium,CRID 3,MCC 950,CRID-3
  • 1-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-[[4-(1-hydroxy-1-methyl-ethyl)-2-furyl]sulfonyl]urea
  • CP 45677 sodium
  • CP45677 sodium
  • CP-45677 sodium
  • MCC950 sodium, 10 mM in DMSO
  • NLRP3 Inhibitor, MCC950
  • MCC950 sodium (Synonyms: CP-456773 sodium
  • NLRP3 Inhibitor
  • 256373-96-3
  • C20H23N2O5SNa
  • C20H23N2NaO5S
  • API