N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE
- Product Name
- N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE
- CAS No.
- 23126-82-1
- Chemical Name
- N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE
- Synonyms
- AKOS BBS-00003135;6-Chloro-N-methyl-5-nitro-4-pyrimidinamine;N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE;4-Pyrimidinamine, 6-chloro-N-methyl-5-nitro-
- CBNumber
- CB7260333
- Molecular Formula
- C5H5ClN4O2
- Formula Weight
- 188.57
- MOL File
- 23126-82-1.mol
N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE Property
- Melting point:
- 134 °C
- Boiling point:
- 374.9±42.0 °C(Predicted)
- Density
- 1.582±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -0.74±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C429353
- Product name
- 6-Chloro-N-methyl-5-nitro-4-pyrimidinamine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FC156281
- Product name
- 6-Chloro-N-methyl-5-nitro-4-pyrimidinamine
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FC156281
- Product name
- 6-Chloro-N-methyl-5-nitro-4-pyrimidinamine
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 072587
- Product name
- 6-Chloro-N-methyl-5-nitro-4-pyrimidinamine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $231
- Updated
- 2021/12/16
- Product number
- J50356
- Product name
- 6-Chloro-N-methyl-5-nitro-4-pyrimidinamine
- Packaging
- 250mg
- Price
- $234
- Updated
- 2021/12/16
N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE Chemical Properties,Usage,Production
Synthesis
4316-93-2
74-89-5
23126-82-1
To a stirred solution of 4,6-dichloro-5-nitropyrimidine (1.5 mmol), monomethylamine (0.5 mmol), Pd2(dba)3 (0.01 mmol), R-BINAP (0.03 mmol), and potassium carbonate (0.7 mmol) in toluene (5 mL) was reacted under argon protection for 3.5 hours at room temperature. Upon completion of the reaction, the mixture was filtered and concentrated. The residue was purified by silica gel column chromatography to afford the target product 6-chloro-N-methyl-5-nitro-4-pyrimidinamine.
References
[1] Chinese Chemical Letters, 2017, vol. 28, # 3, p. 583 - 587
[2] Patent: EP1598354, 2005, A1. Location in patent: Page/Page column 90
[3] Journal of Applied Chemistry, 1957, vol. 7, p. 109,112
[4] Journal of the American Chemical Society, 1957, vol. 79, p. 490,493
[5] European Journal of Medicinal Chemistry, 2010, vol. 45, # 8, p. 3389 - 3393
N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE Preparation Products And Raw materials
Raw materials
Preparation Products
N4-METHYL-6-CHLORO-5-NITROPYRIMIDIN-4-AMINE Suppliers
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- 021-31261262/ 49 (0)17662837245
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