ASP 2151

Product Name: ASP 2151
CAS No.: 841301-32-4
Chemical Name: ASP 2151
Synonyms: CS-2753;ASP 2151;Amcnamevir;AMenaMevir;Amenamevil;Amenamevir (ASP2151);ASP 2151 (Amenamevir);ASP2151;ASP 2151;ASP-2151;Rosuvastatin Impurity 184;Amenamevir, 10 mM in DMSO
CBNumber: CB72627341
Molecular Formula: C24H26N4O5S
Formula Weight: 482.55
MOL File: 841301-32-4.mol

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ASP 2151 Property

Density: 1.360±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF:PBS (pH 7.2) (1:20):0.04(Max Conc. mg/mL);0.08(Max Conc. mM)
DMF:2.0(Max Conc. mg/mL);4.14(Max Conc. mM)
form: A solid
pka: 12.60±0.70(Predicted)
color: White to off-white
InChIKey: MNHNIVNAFBSLLX-UHFFFAOYSA-N
SMILES: C1S(=O)(=O)CCC(C(N(C2=C(C)C=CC=C2C)CC(NC2=CC=C(C3N=CON=3)C=C2)=O)=O)C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML4173
Product name: Amenamevir
Purity: ≥98% (HPLC)
Packaging: 1 unit
Price: $399
Updated: 2025/07/31

Cayman Chemical

Product number: 27921
Product name: Amenamevir
Packaging: 1mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 27921
Product name: Amenamevir
Packaging: 25mg
Price: $1652
Updated: 2024/03/01

Cayman Chemical

Product number: 27921
Product name: Amenamevir
Packaging: 5mg
Price: $452
Updated: 2024/03/01

Cayman Chemical

Product number: 27921
Product name: Amenamevir
Packaging: 10mg
Price: $783
Updated: 2024/03/01

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ASP 2151 Chemical Properties,Usage,Production

Description

Amenamevir is an antiviral inhibitor of herpes simplex virus 1 (HSV-1) helicase-primase complex activity. It inhibits recombinant HSV-1 helicase with an IC₅₀ value of 0.078 μM and recombinant HSV-1 primase when used at concentrations greater than or equal to 0.03 μM. Amenamevir inhibits replication of varicella-zoster virus (VZV), HSV-1, and HSV-2 in human embryonic fibroblast (HEF) cells (EC₅₀s = 0.047, 0.036, and 0.028 μM, respectively) and is not cytotoxic to HEF cells with a 50% cytotoxic concentration (CC₅₀) of greater than 30 μM. Amenamevir also inhibits replication of clinical VZV isolates in HEF cells (EC₅₀s = 0.038-0.10 μM). In vivo, it increases survival of cutaneously HSV-1-infected mice in a zosteriform-spread model of progressive HSV-1 infection (ED₅₀ = 1.9 mg/kg twice per day).

Uses

Amenamevir is a helicase-primase inhibitor which has potent antiviral activity against HSVs with an EC50 of 14 ng/mL.

in vivo

Amenamevir (ASP2151) administration accelerates the reduction in virus titer in a dose-dependent manner in the range of 3 to 30 mg/kg/day. Amenamevir treatment decreases both lesion scores and HSV-1 titers in a dose-dependent manner, irrespective of the dosing interval. Based on the correlation curves, the PK parameters at which HSV-1 growth is completely suppressed by oral administration of Amenamevir are estimated to be 10,000 ng/mL or higher for the maximum concentration of drug in serum (C_max), 60 μg ? h/ml or higher for concentration-time curve over 24 h (AUC_24h), and 21 to 24 h for T_>100 . The mean concentration of Amenamevir in plasma at 5 days postinfection increases in a dose-dependent manner, with doses of 3 mg Amenamevir/g or higher significantly reducing the intradermal HSV-1 titer^[1].

IC 50

HSV-1: 7.7-20 ng/mL (IC₅₀); HSV-2: 15-58 ng/mL (IC₅₀)

References

[1] KOJI CHONO. ASP2151, a novel helicase-primase inhibitor, possesses antiviral activity against varicella-zoster virus and herpes simplex virus types 1 and 2.[J]. Journal of Antimicrobial Chemotherapy, 2010, 65 8: 1733-1741. DOI: 10.1093/jac/dkq198

ASP 2151 Preparation Products And Raw materials

Raw materials

Preparation Products

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ASP 2151 Suppliers

China 90 India 3 United States 7 Global 100

Shanghai Kuanghao Chemistry Technology Co., Ltd.

Tel: 1590082856 15900820856
Fax: 021-37285512
Email: 83219210@qq.com
Country: China
ProdList: 77
Advantage: 57

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

ZHIWE CHEMTECH CO LTD

Tel: 021-20221225 13917446399
Fax: QQ:115820162
Email: zwchem@163.com
Country: China
ProdList: 617
Advantage: 61

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

Shanghai Biolang biotechnology Co.,Ltd

Tel: 17764003753
Fax: 13669031409
Email: 2326587775@qq.com
Country: China
ProdList: 188
Advantage: 55

Shanghai Biolang biotechnology Co.,Ltd

Tel: 17764003753
Fax: 13669031409
Email: 2326587775@qq.com
Country: China
ProdList: 188
Advantage: 55

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View Lastest Price from ASP 2151 manufacturers

S&Y Biochem Co.,Ltd

Product: ASP 2151 841301-32-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: kg
Release date: 2024-10-14

Shenzhen Excellent Biotech Co., Ltd.

Product: Amenamevir 841301-32-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000KG
Release date: 2020-08-21

Career Henan Chemical Co

Product: ASP 2151 841301-32-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-24

841301-32-4, ASP 2151Related Search:

Velpatasvir

ASP 2151

AMenaMevir

N-(2,6-Dimethylphenyl)tetrahydro-N-[2-[[4-(1,2,4-oxadiazol-3-yl)phenyl]amino]-2-oxoethyl]-2H-thiopyran-4-carboxamide 1,1-dioxide

ASP 2151 (Amenamevir)

CS-2753

ASP2151;ASP 2151;ASP-2151

N-(2,6-Dimethylphenyl)-N-(2-{[4-(1,2,4-oxadiazol-3-yl)phenyl] amino}-2-oxoethyl)-1,1-dioxothiane-4-carboxamide

N-(2-((4-(1,2,4-Oxadiazol-3-yl)phenyl)amino)-2-oxoethyl)-N-(2,6-dimethylphenyl)tetrahydro-2H-thiopyran-4-carboxamide 1,1-dioxide

Amenamevir (ASP2151)

2H-Thiopyran-4-carboxamide, N-(2,6-dimethylphenyl)tetrahydro-N-[2-[[4-(1,2,4-oxadiazol-3-yl)phenyl]amino]-2-oxoethyl]-, 1,1-dioxide

Amcnamevir

Herpes simplex virus,Amenamevir,Inhibitor,ASP-2151,HSV,ASP 2151,inhibit

Amenamevil

(2E)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-Propenoic acid 1-methylethyl ester

Rosuvastatin Impurity 184

Amenamevir, 10 mM in DMSO

841301-32-4