ETP46464

Product Name: ETP46464
CAS No.: 1345675-02-6
Chemical Name: ETP46464
Synonyms: ETP46464;ETP46464 USP/EP/BP;ETP 46464; ETP46464;ATR Inhibitor III ETP-46464;2-methyl-2-[4-(2-oxo-9-quinolin-3-yl-4H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl]propanenitrile;2-Methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2,4-dihydro-1H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl);2-methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl)phenyl)propanenitrile;Benzeneacetonitrile, α,α-dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-;alpha,alpha-Dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-benzeneacetonitrile;alpha,alpha-Dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-benzeneacetonitrile ETP46464
CBNumber: CB72662737
Molecular Formula: C30H22N4O2
Formula Weight: 470.52
MOL File: 1345675-02-6.mol

More

Less

ETP46464 Property

Boiling point:: 709.3±60.0 °C(Predicted)
Density: 1.310±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥16.13 mg/mL in DMSO
form: solid
pka: 5.10±0.20(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.00508
Product name: ATR Inhibitor III, ETP-46464 - CAS 1345675-02-7 - Calbiochem
Packaging: 10MG
Price: $265
Updated: 2024/03/01

Cayman Chemical

Product number: 19809
Product name: ETP-46464
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 19809
Product name: ETP-46464
Purity: ≥98%
Packaging: 5mg
Price: $134
Updated: 2024/03/01

Cayman Chemical

Product number: 19809
Product name: ETP-46464
Purity: ≥98%
Packaging: 10mg
Price: $249
Updated: 2024/03/01

TRC

Product number: E936900
Product name: ETP-46464
Packaging: 10mg
Price: $305
Updated: 2021/12/16

More

Less

ETP46464 Chemical Properties,Usage,Production

Uses

ETP-46464 is used as an ATR inhibitor in the treatment of cancer-associated mutations.

Biological Activity

etp-46464 is a potent and selective inhibitor for atr (ic50 = 25 nm).atr (atm- and rad3-related) is a member of pikk (phosphatidylinositol 3-kinase-like kinases) that regulates the dna damage response pathways. it is a dna damage sensor that is activated upon genotoxic stresses (e.g. ionizing radiation, uv radiation and dna replication stalling) and phosphorylates its downstream substrates (e.g. p53, brca1 and chek1).etp-46464 abolished the g2/m checkpoint. it caused the presence of micronuclei or completely fragmented nuclei in cells under ionizing radiation. cells treated simultaneously with hydroxyurea and etp-46464 exhibited elevated atm and chk2 phosphorylation. in u2os cells, etp-46464 promoted the breakage of stalked replication forks. [1]

target

mTOR

References

1. toledo li, murga m, zur r et al. a cell-based screen identifies atr inhibitors with synthetic lethal properties for cancer-associated mutations. nat struct mol biol. 2011 jun;18(6):721-7.

ETP46464 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ETP46464 Suppliers

China 87 France 1 India 2 United States 17 Global 107

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4647
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

TargetMol Chemicals Inc.

Tel: 021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7934
Advantage: 58

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
Advantage: 58

More

Less

View Lastest Price from ETP46464 manufacturers

Career Henan Chemical Co

Product: ETP46464 1345675-02-6
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

1345675-02-6, ETP46464Related Search:

KU-55933 (ATM Kinase Inhibitor) Selumetinib ABT-199 ABT 737 VE 822 PHA-680632

Benzeneacetonitrile, α,α-dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-

alpha,alpha-Dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-benzeneacetonitrile ETP46464

2-methyl-2-[4-(2-oxo-9-quinolin-3-yl-4H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl]propanenitrile

ETP46464

alpha,alpha-Dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-benzeneacetonitrile

ETP 46464; ETP46464

2-Methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2,4-dihydro-1H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl)

ETP46464 USP/EP/BP

ATR Inhibitor III ETP-46464

2-methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl)phenyl)propanenitrile

1345675-02-6

Inhibitors

PI3K/Akt/mTOR

Akt

mTOR

PI3K