ETP46464
- Product Name
- ETP46464
- CAS No.
- 1345675-02-6
- Chemical Name
- ETP46464
- Synonyms
- ETP46464;ETP46464 USP/EP/BP;ETP 46464; ETP46464;ATR Inhibitor III ETP-46464;2-methyl-2-[4-(2-oxo-9-quinolin-3-yl-4H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl]propanenitrile;2-Methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2,4-dihydro-1H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl);2-methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl)phenyl)propanenitrile;Benzeneacetonitrile, α,α-dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-;alpha,alpha-Dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-benzeneacetonitrile;alpha,alpha-Dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-benzeneacetonitrile ETP46464
- CBNumber
- CB72662737
- Molecular Formula
- C30H22N4O2
- Formula Weight
- 470.52
- MOL File
- 1345675-02-6.mol
ETP46464 Property
- Boiling point:
- 709.3±60.0 °C(Predicted)
- Density
- 1.310±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥16.13 mg/mL in DMSO
- form
- solid
- pka
- 5.10±0.20(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- 5.00508
- Product name
- ATR Inhibitor III, ETP-46464 - CAS 1345675-02-7 - Calbiochem
- Packaging
- 10MG
- Price
- $265
- Updated
- 2024/03/01
- Product number
- 19809
- Product name
- ETP-46464
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 19809
- Product name
- ETP-46464
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $134
- Updated
- 2024/03/01
- Product number
- 19809
- Product name
- ETP-46464
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $249
- Updated
- 2024/03/01
- Product number
- E936900
- Product name
- ETP-46464
- Packaging
- 10mg
- Price
- $305
- Updated
- 2021/12/16
ETP46464 Chemical Properties,Usage,Production
Uses
ETP-46464 is used as an ATR inhibitor in the treatment of cancer-associated mutations.
Biological Activity
etp-46464 is a potent and selective inhibitor for atr (ic50 = 25 nm).atr (atm- and rad3-related) is a member of pikk (phosphatidylinositol 3-kinase-like kinases) that regulates the dna damage response pathways. it is a dna damage sensor that is activated upon genotoxic stresses (e.g. ionizing radiation, uv radiation and dna replication stalling) and phosphorylates its downstream substrates (e.g. p53, brca1 and chek1).etp-46464 abolished the g2/m checkpoint. it caused the presence of micronuclei or completely fragmented nuclei in cells under ionizing radiation. cells treated simultaneously with hydroxyurea and etp-46464 exhibited elevated atm and chk2 phosphorylation. in u2os cells, etp-46464 promoted the breakage of stalked replication forks. [1]
target
mTOR
References
1. toledo li, murga m, zur r et al. a cell-based screen identifies atr inhibitors with synthetic lethal properties for cancer-associated mutations. nat struct mol biol. 2011 jun;18(6):721-7.
ETP46464 Preparation Products And Raw materials
Raw materials
Preparation Products
ETP46464 Suppliers
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View Lastest Price from ETP46464 manufacturers
- Product
- ETP46464 1345675-02-6
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23