ChemicalBook > CAS DataBase List > 1-(1-Benzothiophen-4-yl)piperazine hydrochloride

1-(1-Benzothiophen-4-yl)piperazine hydrochloride

Product Name
1-(1-Benzothiophen-4-yl)piperazine hydrochloride
CAS No.
913614-18-3
Chemical Name
1-(1-Benzothiophen-4-yl)piperazine hydrochloride
Synonyms
1-(benzo[b]thiophen-4-yl)piperazine hydrochloride;1-Benzo[b]thien-4-yl-piperazine hydrochloride;7-(4-chlorobutoxy)-1-(4-chlorobutyl)quinolin-2(1H)-one;1-Benzo[b]thien-4-ylpiperazine Monohydrochloride;1-benzo[b]thien-4-yl-;Brexpiprazole intermediate;Brexpiprazole Intermediate 2;Brexpiprazole Impurity 9 HCl;Brexpiprazole Impurity 32 HCl;1-Benzo[b]thien-4-yl-piperazinel HCl
CBNumber
CB72662777
Molecular Formula
C12H15ClN2S
Formula Weight
254.7789
MOL File
913614-18-3.mol
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1-(1-Benzothiophen-4-yl)piperazine hydrochloride Property

Melting point:
>250°C (dec.)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly, Heated), Methanol (Very Slightly)
form 
Solid
color 
White
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

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N-Bromosuccinimide Price

TRC
Product number
B194840
Product name
1-Benzo[b]thien-4-yl-piperazineMonohydrochloride
Packaging
5g
Price
$250
Updated
2021/12/16
SynQuest Laboratories
Product number
7H66-5-65
Product name
1-(1-Benzothiophen-4-yl)piperazinehydrochloride
Packaging
250mg
Price
$175
Updated
2021/12/16
Apolloscientific
Product number
OR305616
Product name
1-(1-Benzothiophen-4-yl)piperazinehydrochloride
Packaging
25g
Price
$244
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB139272
Product name
1-Benzo[b]thien-4-ylpiperazine monohydrochloride
Packaging
25g
Price
$250
Updated
2021/12/16
Apolloscientific
Product number
OR305616
Product name
1-(1-Benzothiophen-4-yl)piperazinehydrochloride
Packaging
5g
Price
$116
Updated
2021/12/16
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1-(1-Benzothiophen-4-yl)piperazine hydrochloride Chemical Properties,Usage,Production

Uses

4-Piperazinylbenzothiophene hydrochloride is the raw material for preparing piperazine-substituted benzothiophene, which can be used for the treatment and prevention of mental diseases including central nervous system diseases.

Synthesis


Synthesis of 4-(1-piperazinyl)benzo[b]thiophene hydrochloride 4-Chlorobenzo[b]thiophene (5.00 g), piperazine (5.11 g), palladium acetate (II) (2.7 mg), tri-tert-butylphosphonium tetraphenylborate (6.2 mg), sodium tert-butoxide (8.548 g), and xylene (70 ml) were stirred at 120 to 130°C for 5 hours. After the reaction mixture was cooled to room temperature, water was added thereto, and the layers were separated. The xylene layer was washed with water, and then with saline. After addition of activated carbon, the mixture was stirred at room temperature for 30 minutes. After filtration of the mixture, concentrated hydrochloric acid was added to the filtrate, and the resulting mixture was stirred at room temperature for 30 minutes. The precipitated crystals were collected by filtration and dried to obtain compound. Yield: 6.94 g. 1H-NMR (DMSO-d6) δ ppm; 3.30 (4H, br.s), 3.61 (4H, br.s), 6.97 (1H, d, J = 7.8 Hz), 7.32 (1H, br. dd, J = 8.4, 7.8 Hz), 7.53 (1H, d, J = 5.6 Hz), 7.70 (1H, d, J = 8.4 Hz), 7.76 (1H, d, J = 5.6 Hz), 9.37 (1H, br.s).

1-(1-Benzothiophen-4-yl)piperazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(1-Benzothiophen-4-yl)piperazine hydrochloride Suppliers

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View Lastest Price from 1-(1-Benzothiophen-4-yl)piperazine hydrochloride manufacturers

Jinan Finer Chemical Co., Ltd
Product
1-Benzo[b]thien-4-ylpiperazine monohydrochloride 913614-18-3
Price
US $0.00/Kg/Drum
Min. Order
10g
Purity
99%
Supply Ability
100mt/year
Release date
2021-06-23
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
1-(1-Benzothiophen-4-yl)piperazine hydrochloride 913614-18-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-03-29
Henan Fengda Chemical Co., Ltd
Product
1-(1-Benzothiophen-4-yl)piperazine hydrochloride 913614-18-3
Price
US $35.00-0.90/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-22

913614-18-3, 1-(1-Benzothiophen-4-yl)piperazine hydrochlorideRelated Search:

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  • 1-benzo[b]thien-4-yl-, hydrochloride
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  • 7-(4-chlorobutoxy)-1-(4-chlorobutyl)quinolin-2(1H)-one
  • 1-(benzo[b]thiophen-4-yl)piperazine hydrochloride
  • 1-Benzo[b]thien-4-yl-piperazinel HCl
  • 1-(1-benzothiophene-4-yl)piperazine monohydrochloride
  • PIPERAZINE, 1-BENZO[B]THIEN-4-YL,HYDROCLORIDE
  • 1-(1-Benzothiophene-4-Yl)Piperazine Hydrochloroide -
  • 1-(4-Benzothienyl)piperazine Hydrochloride
  • Piperazine, 1-benzo[b]thien-4-yl-, hydrochloride (1:1)
  • Brexpiprazole intermediate
  • 1-Benzo[b] thien-4-yl-piperzine hydrochloride
  • 1-benzo[b]thiophene-4-yl-piperazine hydrochloride
  • 1-(1-benzo[b]thien-4-yl )piperazine hydrochloride
  • 1-benzo[b]thien-4-yl-Piperazine hydrochloride (1:1)
  • Brexpiprazole Impurity 32 HCl
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  • 913614-18-3