1-(1-Benzothiophen-4-yl)piperazine hydrochloride
- Product Name
- 1-(1-Benzothiophen-4-yl)piperazine hydrochloride
- CAS No.
- 913614-18-3
- Chemical Name
- 1-(1-Benzothiophen-4-yl)piperazine hydrochloride
- Synonyms
- 1-(benzo[b]thiophen-4-yl)piperazine hydrochloride;1-Benzo[b]thien-4-yl-piperazine hydrochloride;7-(4-chlorobutoxy)-1-(4-chlorobutyl)quinolin-2(1H)-one;1-Benzo[b]thien-4-ylpiperazine Monohydrochloride;1-benzo[b]thien-4-yl-;Brexpiprazole intermediate;Brexpiprazole Intermediate 2;Brexpiprazole Impurity 9 HCl;Brexpiprazole Impurity 32 HCl;1-Benzo[b]thien-4-yl-piperazinel HCl
- CBNumber
- CB72662777
- Molecular Formula
- C12H15ClN2S
- Formula Weight
- 254.7789
- MOL File
- 913614-18-3.mol
1-(1-Benzothiophen-4-yl)piperazine hydrochloride Property
- Melting point:
- >250°C (dec.)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly, Heated), Methanol (Very Slightly)
- form
- Solid
- color
- White
Safety
- HS Code
- 2934999090
N-Bromosuccinimide Price
- Product number
- B194840
- Product name
- 1-Benzo[b]thien-4-yl-piperazineMonohydrochloride
- Packaging
- 5g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 7H66-5-65
- Product name
- 1-(1-Benzothiophen-4-yl)piperazinehydrochloride
- Packaging
- 250mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- OR305616
- Product name
- 1-(1-Benzothiophen-4-yl)piperazinehydrochloride
- Packaging
- 25g
- Price
- $244
- Updated
- 2021/12/16
- Product number
- FB139272
- Product name
- 1-Benzo[b]thien-4-ylpiperazine monohydrochloride
- Packaging
- 25g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- OR305616
- Product name
- 1-(1-Benzothiophen-4-yl)piperazinehydrochloride
- Packaging
- 5g
- Price
- $116
- Updated
- 2021/12/16
1-(1-Benzothiophen-4-yl)piperazine hydrochloride Chemical Properties,Usage,Production
Uses
4-Piperazinylbenzothiophene hydrochloride is the raw material for preparing piperazine-substituted benzothiophene, which can be used for the treatment and prevention of mental diseases including central nervous system diseases.
Synthesis
Synthesis of 4-(1-piperazinyl)benzo[b]thiophene hydrochloride 4-Chlorobenzo[b]thiophene (5.00 g), piperazine (5.11 g), palladium acetate (II) (2.7 mg), tri-tert-butylphosphonium tetraphenylborate (6.2 mg), sodium tert-butoxide (8.548 g), and xylene (70 ml) were stirred at 120 to 130°C for 5 hours. After the reaction mixture was cooled to room temperature, water was added thereto, and the layers were separated. The xylene layer was washed with water, and then with saline. After addition of activated carbon, the mixture was stirred at room temperature for 30 minutes. After filtration of the mixture, concentrated hydrochloric acid was added to the filtrate, and the resulting mixture was stirred at room temperature for 30 minutes. The precipitated crystals were collected by filtration and dried to obtain compound. Yield: 6.94 g. 1H-NMR (DMSO-d6) δ ppm; 3.30 (4H, br.s), 3.61 (4H, br.s), 6.97 (1H, d, J = 7.8 Hz), 7.32 (1H, br. dd, J = 8.4, 7.8 Hz), 7.53 (1H, d, J = 5.6 Hz), 7.70 (1H, d, J = 8.4 Hz), 7.76 (1H, d, J = 5.6 Hz), 9.37 (1H, br.s).
1-(1-Benzothiophen-4-yl)piperazine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
1-(1-Benzothiophen-4-yl)piperazine hydrochloride Suppliers
View Lastest Price from 1-(1-Benzothiophen-4-yl)piperazine hydrochloride manufacturers
- Product
- 1-Benzo[b]thien-4-ylpiperazine monohydrochloride 913614-18-3
- Price
- US $0.00/Kg/Drum
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 100mt/year
- Release date
- 2021-06-23
- Product
- 1-(1-Benzothiophen-4-yl)piperazine hydrochloride 913614-18-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2024-03-29
- Product
- 1-(1-Benzothiophen-4-yl)piperazine hydrochloride 913614-18-3
- Price
- US $35.00-0.90/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-22