HJC-0350

Product Name: HJC-0350
CAS No.: 885434-70-8
Chemical Name: HJC-0350
Synonyms: CS-1879;HJC0350;HJC 0350;HJC-0350;HJC-0350;HJC0350;HJC 0350;1-(Mesitylsulfonyl)-2,4-diMethyl-1H-pyrrole;inhibit,HJC-0350,Inhibitor,HJC 0350,HJC0350;2,4-dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole;1H-Pyrrole, 2,4-dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-;2,4-Dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole HJC 0350
CBNumber: CB72668476
Molecular Formula: C15H19NO2S
Formula Weight: 277.38
MOL File: 885434-70-8.mol

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HJC-0350 Property

Boiling point:: 434.6±55.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: soluble5mg/mL, clear
pka: -6.94±0.70(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0820
Product name: HJC0350
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $109
Updated: 2022/05/15

Sigma-Aldrich

Product number: SML0820
Product name: HJC0350
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $425
Updated: 2022/05/15

Cayman Chemical

Product number: 22949
Product name: HJC0350
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 22949
Product name: HJC0350
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 22949
Product name: HJC0350
Purity: ≥98%
Packaging: 10mg
Price: $139
Updated: 2024/03/01

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HJC-0350 Chemical Properties,Usage,Production

Uses

HJC 0350 is a potent and selective inhibitor of EPAC2 and exhibits no inhibition of EPAC1.

Biological Activity

hjc 0350 is a potent and selective antagonist of epac2 with ic50 value of 0.3 μm [1].camp/camp regulated guanine nucleotide exchange factor (epac/camp-gef) is a guanine nucleotide exchange factor for the small gtpases rap1 and rap2 in response to intracellular camp. epac2 is mainly expressed in the central nervous system, pancreas and adrenal gland [1].hjc 0350 is a potent and selective epac2 antagonist. hjc 0350 competed with 8-nbd-camp in binding recombinant fusion protein epac2 with ic50 value of 0.3 μm and exhibited 133-fold more potent than camp, which competed with 8-nbd-camp in binding epac2 with ic50 value of 40 μm. in the presence of 25 μm camp, hjc 0350 (25 μm) inhibited epac2 gef activity but had no effect on epac1-mediated rap1-gdp exchange activity and camp-mediated pka activation, which suggested that hjc 0350 was epac2-specific antagonist. in hek293 cells expressing epac1- or epac2-based fluorescence resonance energy transfer (fret) sensor (epac2-fl or epac1-fl), hjc 0350 (10 μm) completely inhibited the 007-am (a membrane permeable epac selective camp analogue) induced decrease of fret in hek293/epac2-fl cells but had no effect on hek293/epac1-fl cells [1].

storage

Store at +4°C

References

[1]. chen h, tsalkova t, chepurny og, et al. identification and characterization of small molecules as potent and specific epac2 antagonists. j med chem, 2013, 56(3): 952-962.

HJC-0350 Preparation Products And Raw materials

Raw materials

Preparation Products

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HJC-0350 Suppliers

China 52 India 1 United Kingdom 2 United States 13 Global 68

MedChemexpress LLC

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885434-70-8, HJC-0350Related Search:

RO-31-8220 AS-252424 CEP-18770 PD 0325901 Gentamicin sulfate PRT062607 (Hydrochloride)

HJC 0350

HJC0350

HJC-0350

1-(Mesitylsulfonyl)-2,4-diMethyl-1H-pyrrole

2,4-dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole

2,4-Dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole HJC 0350

HJC-0350;HJC0350;HJC 0350

CS-1879

1H-Pyrrole, 2,4-dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-

inhibit,HJC-0350,Inhibitor,HJC 0350,HJC0350

885434-70-8

Inhibitors