ChemicalBook > CAS DataBase List > GSK J1

GSK J1

Product Name
GSK J1
CAS No.
1373422-53-7
Chemical Name
GSK J1
Synonyms
GSK-J1;GSK J1;GCK J1;CS-2305;Histone demethylase inhibitor J1;GSK-J1, H3K27 histone demethylase inhibitor;Histone Lysine Demethylase Inhibitor VII, GSK-J1;Histone Lysine Demethylase Inhibitor VII, GSK-J1 - CAS 1373422-53-7 - Calbiochem;N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyriMidinyl]-|-alanine;β-Alanine, N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-
CBNumber
CB72668658
Molecular Formula
C22H23N5O2
Formula Weight
389.45
MOL File
1373422-53-7.mol
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GSK J1 Property

Boiling point:
608.9±55.0 °C(Predicted)
Density 
1.292±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble15mg/mL, clear
form 
powder
pka
4.20±0.10(Predicted)
color 
white to beige
Stability:
Stable for 2 years from date of purchase? as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey
AVZCPICCWKMZDT-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0709
Product name
GSK-J1
Purity
≥98% (HPLC)
Packaging
5mg
Price
$78
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0709
Product name
GSK-J1
Purity
≥98% (HPLC)
Packaging
25mg
Price
$191.2
Updated
2024/03/01
Tocris
Product number
4593
Product name
GSKJ1
Purity
≥99%(HPLC)
Packaging
10
Price
$216
Updated
2021/12/16
Tocris
Product number
4593
Product name
GSKJ1
Purity
≥99%(HPLC)
Packaging
50
Price
$891
Updated
2021/12/16
Usbiological
Product number
451480
Product name
GSK J1
Packaging
10mg
Price
$460
Updated
2021/12/16
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GSK J1 Chemical Properties,Usage,Production

Description

GSK-J1 (1373422-53-7) is a potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such GSK-J1 is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available, see GSK-J4 (cat.# 10-1394).

Uses

GSK J1 is a selective and potent inhibitor of JMJDE and UTX demethylases.

Definition

ChEBI: 3-[[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-4-pyrimidinyl]amino]propanoic acid is an organonitrogen heterocyclic compound.

Biochem/physiol Actions

GSK-J1 is also termed as 3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate. It may disturb the differentiation of specific neuronal subtypes in growing rat retina.

storage

room temperature (desiccate)

References

1) Kruidenier et al. (2012), A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response; Nature, 488 404

GSK J1 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK J1 Suppliers

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View Lastest Price from GSK J1 manufacturers

Shaanxi Haibo Biotechnology Co., Ltd
Product
GSK J1 1373422-53-7
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-08-29
Career Henan Chemical Co
Product
GSK-J1 1373422-53-7
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1ton
Release date
2020-01-10

1373422-53-7, GSK J1Related Search:

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  • GSK J1
  • GSK-J1
  • N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine
  • GCK J1
  • 3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoic acid
  • N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyriMidinyl]-|-alanine
  • Histone Lysine Demethylase Inhibitor VII, GSK-J1
  • Histone Lysine Demethylase Inhibitor VII, GSK-J1 - CAS 1373422-53-7 - Calbiochem
  • Histone demethylase inhibitor J1
  • CS-2305
  • β-Alanine, N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-
  • N - [2- (2-pyridyl) -6- (1,2,4,5-tetrahydro-3H-3-benzoazo-3-yl) -4-pyrimidinyl] - BETA-alanine
  • GSK-J1, H3K27 histone demethylase inhibitor
  • 1373422-53-7
  • 1343722-53-7
  • API