GSK J1

ChemicalBook > CAS DataBase List > GSK J1

Product Name: GSK J1
CAS No.: 1373422-53-7
Chemical Name: GSK J1
Synonyms: GSK-J1;GSK J1;GCK J1;CS-2305;Histone demethylase inhibitor J1;Histone Lysine Demethylase Inhibitor VII, GSK-J1;Histone Lysine Demethylase Inhibitor VII, GSK-J1 - CAS 1373422-53-7 - Calbiochem;N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyriMidinyl]-|-alanine;β-Alanine, N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-;N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine
CBNumber: CB72668658
Molecular Formula: C22H23N5O2
Formula Weight: 389.45
MOL File: 1373422-53-7.mol

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GSK J1 Property

Boiling point:: 608.9±55.0 °C(Predicted)
Density: 1.292±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble15mg/mL, clear
form: powder
pka: 4.20±0.10(Predicted)
color: white to beige
Stability:: Stable for 2 years from date of purchase? as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey: AVZCPICCWKMZDT-UHFFFAOYSA-N

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0709
Product name: GSK-J1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0709
Product name: GSK-J1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $191.2
Updated: 2024/03/01

Tocris

Product number: 4593
Product name: GSKJ1
Purity: ≥99%(HPLC)
Packaging: 10
Price: $216
Updated: 2021/12/16

Tocris

Product number: 4593
Product name: GSKJ1
Purity: ≥99%(HPLC)
Packaging: 50
Price: $891
Updated: 2021/12/16

Usbiological

Product number: 451480
Product name: GSK J1
Packaging: 10mg
Price: $460
Updated: 2021/12/16

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GSK J1 Chemical Properties,Usage,Production

Description

GSK-J1 (1373422-53-7) is a potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such GSK-J1 is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available, see GSK-J4 (cat.# 10-1394).

Uses

GSK J1 is a selective and potent inhibitor of JMJDE and UTX demethylases.

Definition

ChEBI: 3-[[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)-4-pyrimidinyl]amino]propanoic acid is an organonitrogen heterocyclic compound.

Biochem/physiol Actions

GSK-J1 is also termed as 3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate. It may disturb the differentiation of specific neuronal subtypes in growing rat retina.

storage

room temperature (desiccate)

References

1) Kruidenier et al. (2012), A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response; Nature, 488 404

GSK J1 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK J1 Suppliers

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View Lastest Price from GSK J1 manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: GSK J1 1373422-53-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-29

Career Henan Chemical Co

Product: GSK-J1 1373422-53-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1ton
Release date: 2020-01-10

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GSK J1

GSK-J1

N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-beta-alanine

GCK J1

3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoic acid

N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyriMidinyl]-|-alanine

Histone Lysine Demethylase Inhibitor VII, GSK-J1

Histone Lysine Demethylase Inhibitor VII, GSK-J1 - CAS 1373422-53-7 - Calbiochem

Histone demethylase inhibitor J1

CS-2305

β-Alanine, N-[2-(2-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-

N - [2- (2-pyridyl) -6- (1,2,4,5-tetrahydro-3H-3-benzoazo-3-yl) -4-pyrimidinyl] - BETA-alanine

1373422-53-7

1343722-53-7

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