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AcotiaMide

Product Name
AcotiaMide
CAS No.
185106-16-5
Chemical Name
AcotiaMide
Synonyms
Acofide;AcotiaMide;ACOTIAMIDUM;Acotiamide D4;YM443 free base;Z-338 free base;Acotiamide formate salt;N-{2-[bis(1-methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dime...;N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide;N-(2-(diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide hydrochloride
CBNumber
CB72683927
Molecular Formula
C21H30N4O5S
Formula Weight
450.55
MOL File
185106-16-5.mol
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AcotiaMide Property

Density 
1.246±0.06 g/cm3(Predicted)
storage temp. 
-20°C
pka
7.38±0.50(Predicted)
form 
powder
color 
white to beige
Water Solubility 
H2O: 20mg/mL, clear
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1569
Product name
Acotiamide dihydrochloride
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$67.92
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1569
Product name
Acotiamide dihydrochloride
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$380
Updated
2025/07/31
DC Chemicals
Product number
DC8798
Product name
Acotiamide
Purity
>98%
Packaging
100mg
Price
$200
Updated
2021/12/16
DC Chemicals
Product number
DC8798
Product name
Acotiamide
Purity
>98%
Packaging
250mg
Price
$400
Updated
2021/12/16
CSNpharm
Product number
CSN19809
Product name
Acotiamide
Packaging
50mg
Price
$424
Updated
2021/12/16
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AcotiaMide Chemical Properties,Usage,Production

Uses

Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory[1][2][3].

Definition

ChEBI: Acotiamide is a member of salicylamides.

Biological Activity

Acotiamide is a potent, selective and reversible inhibitor of human and canine stomach-derived acetylcholinesterase (AChE). Acotiamide showed no affinity for dopamine D2 or serotonin 5-HT4 receptors but does have activity as a muscarinic antagonist. It acts as a prokinetic drug through acetylcholinesterase inhibition and muscarinic receptor antagonism, and has been used for the treatment of functional dyspepsia (FD) involving gastric motility dysfunction.

in vivo

Acotiamide (0.3, 1, 3 mg/kg; i.v./3, 10, 30 mg/kg; p.o.) increases the postprandial gastric motility index in a dose-dependent manner[2].
Acotiamide (0.83 mg/kg; i.v.; once) inhibits AChE in rat stomach with an IC50 value of 1.79 μM[3].

Animal Model:Male mongrel dogs (9-11 kg), Male beagle dogs (9.6-12.9 kg)[2]
Dosage:0.3, 1, 3, 10, 30 mg/kg
Administration:Intravenous injection; once
Result:Increased the postprandial gastric motility.
Animal Model:Male Sprague-Dawley rats (aged 6-7 weeks)[3]
Dosage:0.83 mg/kg
Administration:Intravenous injection; once.
Result:Effectively improved functional dyspepsia by inhibiting AChE in rat stomach.

References

[1] Kazuyoshi Y oshii, et al. Physiologically-Based Pharmacokinetic and Pharmacodynamic Modeling for the Inhibition of Acetylcholinesterase by Acotiamide, A Novel Gastroprokinetic Agent for the Treatment of Functional Dyspepsia, in Rat Stomach. Pharmaceutical DOI:10.1007/s11095-015-1787-y
[2] Hiroshi Yamawaki, et al. Acotiamide attenuates central urocortin 2-induced intestinal inflammatory responses, and urocortin 2 treatment reduces TNF-α productions in LPS-stimulated macrophage cell lines. Neurogastroenterol Motil. 2020 Aug;32(8):e13813. DOI:10.1111/nmo.13813
[3] Matsunaga Y, Acotiamide hydrochloride (Z-338), a new selective acetylcholinesterase inhibitor, enhances gastric motility without prolonging QT interval in dogs: comparison with cisapride, itopride, and mosapride. J Pharmacol Exp Ther. 2011 Mar;336(3):791- DOI:10.1124/jpet.110.174847

AcotiaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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AcotiaMide Suppliers

China 90 India 7 United Kingdom 1 United States 3 Global 101
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
TargetMol Chemicals Inc.
Tel
+17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
19962
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
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View Lastest Price from AcotiaMide manufacturers

Moxin Chemicals
Product
Acotiamide 185106-16-5
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
95%+
Supply Ability
10000000
Release date
2025-02-27
Hebei Mingeng Biotechnology Co., Ltd
Product
Acotiamide 185106-16-5
Price
US $200.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg/Month
Release date
2022-11-27
Nanjing Kaitian Chemical Co., LTD
Product
AcotiaMide 185106-16-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2023-02-10

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  • N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide
  • N-(2-(diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide hydrochloride
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  • 4-Thiazolecarboxamide, N-[2-[bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-
  • Acotiamide formate salt
  • N-{2-[bis(1-methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dime...
  • Acotiamide D4
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  • YM443 free base
  • Z-338 free base
  • 185106-16-5
  • C21H30N4O5S