LY-3009120

Product Name: LY-3009120
CAS No.: 1454682-72-4
Chemical Name: LY-3009120
Synonyms: DP 4978;CS-1616;LY-3009120;LY03009120(DP-4978);LY-3009120（DP-4978）;LY3009120; LY-3009120; LY 3009120; DP-4978; DP 4978; DP4978;Raf kinases,DP 4978,inhibit,LY-3009120,DP4978,Autophagy,LY3009120,Raf,LY 3009120,Inhibitor;N-(3,3-dimethylbutyl)-N'-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]-;N-(3,3-Dimethylbutyl)-N'-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]urea;Urea, N-(3,3-dimethylbutyl)-N'-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]-
CBNumber: CB72725629
Molecular Formula: C23H29FN6O
Formula Weight: 424.51
MOL File: 1454682-72-4.mol

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LY-3009120 Property

Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥4.25 mg/mL in DMSO with gentle warming and ultrasonic
form: solid
pka: 13.52±0.70(Predicted)
color: Light yellow to khaki

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21504
Product name: LY3009120
Purity: ≥98%
Packaging: 5mg
Price: $141
Updated: 2024/03/01

Cayman Chemical

Product number: 21504
Product name: LY3009120
Purity: ≥98%
Packaging: 10mg
Price: $253
Updated: 2024/03/01

Cayman Chemical

Product number: 21504
Product name: LY3009120
Purity: ≥98%
Packaging: 25mg
Price: $558
Updated: 2024/03/01

Cayman Chemical

Product number: 21504
Product name: LY3009120
Purity: ≥98%
Packaging: 50mg
Price: $979
Updated: 2024/03/01

Tocris

Product number: 6854
Product name: LY3009120
Purity: ≥98%(HPLC)
Packaging: 10
Price: $101
Updated: 2021/12/16

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LY-3009120 Chemical Properties,Usage,Production

Uses

LY 3009120 is a potent pan-Rad inhibitor used in the inhibition of tumors. Dose-dependant inhibition.

Definition

ChEBI: LY3009120 is a member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine substituted by methylamino, 5-{[(3,3-dimethylbutyl)carbamoyl]amino}-4-fluoro-2-methylphenyl, and methyl groups at positions 2, 6 and 7, respectively. It is a potent pan RAF inhibitor which inhibits BRAF(V600E), BRAF(WT) and CRAF(WT) (IC50 = 5.8, 9.1 and 15 nM, respectively). It also inhibits RAF homo- and heterodimers and exhibits anti-cancer properties. It has a role as a necroptosis inhibitor, an apoptosis inducer, an antineoplastic agent, a B-Raf inhibitor and an autophagy inducer. It is a pyridopyrimidine, a biaryl, an aromatic amine, a member of phenylureas, a member of monofluorobenzenes, an aminotoluene and a secondary amino compound.

Biological Activity

ly3009120 is a pan-raf and raf dimer inhibitor. it inhibits braf wt, craf, wt, brafv600e, and brafv600e+g468a with the ic50 values of 9.1, 15, 5.8, and 17 nm, respectively. [1]raf is family of serine/threonine-protein kinase mediates ras gtpases and the mapk/erk cascade. it involves in proliferation, differentiation, apoptosis, survival and oncogenic transformation. [1]in nras mutant sk-mel2 cells or kras mutant hct116 cells, ly3009120 inhibits the kinase activity of craf in a dose-dependent manner and induces braf/craf heterodimerization. it also blocks phospho-mek and -erk and induces minimal paradoxical activation in ras mutant cells. moreover, treatment of braf v600e a375 melanoma cells by ly3009120 for 24 hr predominantly induces a g0/g1 arrest with more than 95% cells in g0/g1 phase. [1]in nude rats bearing a375 xenograft tumors, oral ly3001920 treatment exerts a dose-dependent inhibition of phospho-mek and –erk. 15 or 30 mg/kg ly3009120 shows near complete tumor regression in nude rats bearing pdx tumors. [1]

storage

Store at -20°C

References

1. peng sb, henry jr, kaufman md et al. inhibition of raf isoforms and active dimers by ly3009120 leads to anti-tumor activities in ras or braf mutant cancers. cancer cell. 2015 sep 14;28(3):384-98.

LY-3009120 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY-3009120 Suppliers

China 77 India 1 United States 12 Global 90

Musechem

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Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
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BOC Sciences

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1454682-72-4, LY-3009120Related Search:

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LY-3009120

Urea, N-(3,3-dimethylbutyl)-N'-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]-

N-(3,3-dimethylbutyl)-N'-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]-

DP 4978

N-(3,3-Dimethylbutyl)-N'-[2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl]urea

LY3009120; LY-3009120; LY 3009120; DP-4978; DP 4978; DP4978

CS-1616

LY-3009120（DP-4978）

LY03009120(DP-4978)

Raf kinases,DP 4978,inhibit,LY-3009120,DP4978,Autophagy,LY3009120,Raf,LY 3009120,Inhibitor

1454682-72-4

C23H29FN6O