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Febuxostat Impurity 7

Product Name
Febuxostat Impurity 7
CAS No.
1350352-70-3
Chemical Name
Febuxostat Impurity 7
Synonyms
3-Descyano-3-((hydroxyimino)methyl) Febuxostat;Febuxostat-17;Febuxostat Impurity M;Febuxostat Impurity 7;Febuxostat impurities 7;Febuxostat Impurity 7 (F);2-(3-((Hydroxyimino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylicacid;sodium-2-(3-((hydroxyimino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate;(Z)-2-(3-((hydroxyimino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid;2-[3-((hydroxyimino)methyl)-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylicacid
CBNumber
CB72741814
Molecular Formula
C16H18N2O4S
Formula Weight
334.39
MOL File
1350352-70-3.mol
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Febuxostat Impurity 7 Property

Melting point:
>215°C (dec.)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly)
form 
Solid
color 
White
InChI
InChI=1S/C16H18N2O4S/c1-9(2)8-22-13-5-4-11(6-12(13)7-17-21)15-18-10(3)14(23-15)16(19)20/h4-7,9,21H,8H2,1-3H3,(H,19,20)
InChIKey
MDMGIABSBHFMNF-UHFFFAOYSA-N
SMILES
S1C(C(O)=O)=C(C)N=C1C1=CC=C(OCC(C)C)C(C=NO)=C1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
D288140
Product name
3-Descyano-3-((hydroxyimino)methyl)Febuxostat
Packaging
1g
Price
$2420
Updated
2021/12/16
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Febuxostat Impurity 7 Chemical Properties,Usage,Production

Uses

3-Descyano-3-((hydroxyimino)methyl) Febuxostat is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor that is used for treating hyperuricemia and chronic gout.

Synthesis

Preparation of 2-[3-((hydroxyimino)methyl)-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid (febuxostat impurity 7) Compound: to pre-cooled sodium hydroxide was added ethyl 2-[3-((hydroxyimino)methyl)-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate (100 g) in methanol (500 mL) solution solution (22.10 g in 500 mL of water). The reaction mixture was heated to 75 C and stirred at the same temperature for 30 minutes. Water (5 g) was added to the reaction mixture and the reaction mixture was cooled to 25 C. Methanol (100 ml) and water (100 ml) were added to the reaction mixture. The pH was adjusted to 2.0-3.0 using aqueous hydrochloric acid. the reaction mixture was stirred for 5 hours. Filter the precipitated solid and wash with methanol and water. Dry the resulting material. Tetrahydrofuran (270 ml) and carbon (2.25 gms) were added to the resulting material. The reaction mixture was stirred for 30 min and filtered through hyflow. The solvent was completely distilled from the filtrate. Methanol (450 ml) was added to the resulting compound and stirred at 60C for 30 min. The reaction mixture was cooled to 25C and stirred for 2 hours. The precipitated solid was filtered and the substance was dried to give the pure title compound febuxostat impurity 7. Yield: 70 g.

Febuxostat Impurity 7 Preparation Products And Raw materials

Raw materials

Preparation Products

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Febuxostat Impurity 7 Suppliers

China 61 India 5 United Kingdom 1 United States 5 Global 72
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1350352-70-3, Febuxostat Impurity 7Related Search:

2-[3-(S)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]phenyl-2-propanol L 768232 Montelukast Michael Adduct R,S-IsoMer cis-Montelukast Epalrestat iMpurity isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate Febuxostat Impurity 14 2-(3-cyano-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid Febuxostat Impurity 6 2,2'-[4-(2-Methylpropoxy)-1,3-phenylene]bis[4-Methyl-5-thiazolecarboxylic Acid 2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid 2-(3-cyano-4-propoxyphenyl)-4-methylthiazole-5-carboxylic acid Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE Febuxostat Impurity 8 4-(2-Methylpropoxy)-1,3-benzenedicarbothioaMide (3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile

  • Febuxostat Impurity 24/(Z)-2-(3-((hydroxyimino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid
  • Febuxostat-17
  • Febuxostat Impurity 7
  • (Z)-2-(3-((hydroxyimino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid
  • Febuxostat Impurity M
  • 3-Descyano-3-((hydroxyimino)methyl) Febuxostat
  • Febuxostat Impurity 7 (F)
  • 2-(3-((Hydroxyimino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylicacid
  • Febuxostat impurities 7
  • 5-Thiazolecarboxylic acid, 2-[3-[(hydroxyimino)methyl]-4-(2-methylpropoxy)phenyl]-4-methyl-
  • 2-[3-((hydroxyimino)methyl)-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylicacid
  • sodium-2-(3-((hydroxyimino)methyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
  • 2-[3-[(Hydroxyimino)methyl]-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid
  • Febuxostat Oxime Impurity: 2-[3-[(Hydroxyimino)methyl]-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid
  • 1350352-70-3