ChemicalBook > CAS DataBase List > tert-Butyl N-hydroxycarbamate

tert-Butyl N-hydroxycarbamate

Product Name
tert-Butyl N-hydroxycarbamate
CAS No.
36016-38-3
Chemical Name
tert-Butyl N-hydroxycarbamate
Synonyms
tert-Butyl hydroxycarbamate;N-BOC-HYDROXYLAMINE;BOC-NH-OH;BOC-HNOH;N-Boc-hydroxyL;BOC hydroxylamine;N-Boc-Hydroxyamine;N-hydroxycarbamate;N-T-BOC HYDROXYLAMINE;LABOTEST-BB LT00233206
CBNumber
CB7274369
Molecular Formula
C5H11NO3
Formula Weight
133.15
MOL File
36016-38-3.mol
More
Less

tert-Butyl N-hydroxycarbamate Property

Melting point:
53-55 °C (lit.)
Boiling point:
245.66°C (rough estimate)
Density 
1.2510 (rough estimate)
refractive index 
1.4120 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform, Methanol
pka
9.31±0.23(Predicted)
form 
Crystalline Powder
color 
White to light pink
Water Solubility 
Slightly soluble in water.
Sensitive 
Moisture Sensitive
BRN 
1756546
InChI
InChI=1S/C5H11NO3/c1-5(2,3)9-4(7)6-8/h8H,1-3H3,(H,6,7)
InChIKey
DRDVJQOGFWAVLH-UHFFFAOYSA-N
SMILES
C(OC(C)(C)C)(=O)NO
CAS DataBase Reference
36016-38-3(CAS DataBase Reference)
More
Less

Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
21
HS Code 
29280090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
226157
Product name
N-Boc-hydroxylamine
Purity
≥98%
Packaging
5g
Price
$97.4
Updated
2024/03/01
Sigma-Aldrich
Product number
226157
Product name
N-Boc-hydroxylamine
Purity
≥98%
Packaging
1g
Price
$26
Updated
2023/06/20
TCI Chemical
Product number
H0848
Product name
tert-Butyl N-Hydroxycarbamate
Purity
>98.0%(GC)
Packaging
5g
Price
$17
Updated
2024/03/01
TCI Chemical
Product number
H0848
Product name
tert-Butyl N-Hydroxycarbamate
Purity
>98.0%(GC)
Packaging
25g
Price
$34
Updated
2024/03/01
Alfa Aesar
Product number
A10349
Product name
N-Boc-hydroxylamine, 98+%
Packaging
1g
Price
$27.65
Updated
2024/03/01
More
Less

tert-Butyl N-hydroxycarbamate Chemical Properties,Usage,Production

Chemical Properties

White to light pink crystalline powder

Uses

N-Boc-hydroxylamine is used in the preparation of azridines by cycloaddition of azides with nitroso Diels-Alder adducts. It acts as a reagent for the synthesis of hydroxylamine derivatives t-butyl-N-(acyloxy)carbamates and N,O-diacylated N-hydroxyarylsulfonamides.

Uses

tert-Butyl N-hydroxycarbamate is used in the preparation of azridines by cycloaddition of azides with nitroso Diels-Alder adducts.

Synthesis Reference(s)

Journal of the American Chemical Society, 81, p. 955, 1959 DOI: 10.1021/ja01513a049
Tetrahedron Letters, 24, p. 231, 1983 DOI: 10.1016/S0040-4039(00)81372-6

Synthesis

A suspension of NH2OH·HCl (9.7 g, 140mmol) and K2CO3 (9.7 g, 700 mmol) in Et2O (60 mL) and H2O (2 mL)was stirred for about 1 h at r.t. with evolution of CO2 gas. A solution of Boc2O (20.0 g, 92 mmol) in Et2O (40 mL) was then added dropwise at 0 °C, and the suspension was stirred at r.t for 12 h. The organic phase was decanted, and the solid was washed with Et2O (3 × 30 mL). The combined organic layers were concentrated, and the residue was recrystallized from cyclohexane/toluene to afford the desired product tert-butyl N-hydroxycarbamate as a white solid.

tert-Butyl N-hydroxycarbamate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

tert-Butyl N-hydroxycarbamate Suppliers

Americas 1 Belgium 3 Canada 1 China 271 Europe 1 Germany 8 India 34 Japan 7 Switzerland 2 The Netherlands 1 United Kingdom 15 United States 53 Global 397
Suzhou Highfine Biotech Co., Ltd
Tel
0512-68311833 13962195826
Fax
0512-68417696
Email
wuhao@highfine.com
Country
China
ProdList
499
Advantage
75
Shanghai Qiude Biochemical Engineering Co., Ltd
Tel
021-37285021 13472570865;
Fax
86-021-51714507
Email
info@pure-chiral.com
Country
China
ProdList
304
Advantage
64
Z IntellecChem & Tech. Co., Ltd
Tel
13179383568; 15050866711
Fax
QQ:2677337387
Email
contact@zintellec.com
Country
China
ProdList
390
Advantage
58
Shandong Yukun Chemical Industry Co. LTD
Tel
18660690289
Email
sales@yukunchem.com
Country
China
ProdList
45
Advantage
58
Chongqing Xingcan Pharmaceutical Technology Co., Ltd.
Tel
15523000485
Email
xingcanyaoye@sina.com
Country
China
ProdList
1686
Advantage
58
BTC Pharmaceutical CO. Ltd
Tel
0513-0513-68015397 18862996710
Fax
0513-68015394
Email
sales12@btcpharm.com
Country
China
ProdList
689
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
4986
Advantage
55
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Sichuan Tongsheng Amino acids Co.,Ltd.
Tel
0838-2809458 13350585791
Fax
+86-838-2274207
Email
pharm@biots.cn
Country
China
ProdList
333
Advantage
66
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9413
Advantage
66
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Jiangxi Kingnord Industrial Limited
Tel
0791-86493591
Fax
+86 791 8649 3642
Email
jeff@kingnord.com
Country
China
ProdList
43
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
021-51613915-820 13611835272
Fax
021 51613951
Email
mmwang@sunwaypharm.cn
Country
China
ProdList
9734
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
ZhengZhou HuaWen Chemical Co.Ltd
Tel
0370-2785118 17550508557
Fax
QQ：3470079902
Email
675141927@qq.com
Country
China
ProdList
3203
Advantage
55
Sci General Material & Chemical Ltd
Tel
21-58388037 13472507714
Fax
0086-21-56829747 Company QQ: 1589045147
Email
1589045147@qq.com
Country
China
ProdList
729
Advantage
55
Wuhan Haizheng Industry & Trade Development Co. Ltd
Tel
027-8866 0053/88660577/88660578
Fax
027-8899 1911
Country
China
ProdList
1073
Advantage
55
Shanghai Hope Chem Co., Ltd.，
Tel
+21-18501659228 18501659228
Fax
sales@hope-chem.com
Email
info@hope-chem.com
Country
China
ProdList
481
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9459
Advantage
58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
18017383231 18017383231
Fax
qq：2817624287
Email
lyh_antaeus@163.com
Country
China
ProdList
9347
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Shanghai Medpep Co., Ltd
Tel
021-65566949 13901795941
Fax
86-21-51861665
Email
market@medpep.com
Country
China
ProdList
177
Advantage
66
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Wuxi Zhangkun Biochemical Technology Co., Ltd.
Tel
+86 0510-85629785
Fax
+86 0510-85625359
Country
China
ProdList
2327
Advantage
58
ShangHai Zexin Chemical Technology Co., Ltd.
Tel
021-60136491 15901897992
Fax
021-60136492
Country
China
ProdList
455
Advantage
55
Shanghai BeiZhuo Biotech Co., Ltd.
Tel
021-61119791,13386096464
Fax
021-50190009
Email
bzswkf@foxmail.com
Country
China
ProdList
3921
Advantage
50
Shanghai Hekang Biotechnology Co., Ltd.
Tel
18939837085
Fax
2880152141(QQ)
Email
youchemicals@gmail.com
Country
China
ProdList
1830
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Shanghai DiBai Chemicals Co., Ltd.
Tel
021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3991
Advantage
60
Shanghai Hobor Chemical Co., Ltd
Tel
21-21-61026752 13918007836
Fax
021-51685238
Email
sales@hoborchem.com
Country
China
ProdList
346
Advantage
60
Zhengzhou HongSheng Pharmaceutical Co., Ltd.
Tel
0371-13526885213 15637198702
Fax
0371-63709726
Email
xpkchem@163.com
Country
China
ProdList
3990
Advantage
58
More
Less

View Lastest Price from tert-Butyl N-hydroxycarbamate manufacturers

Xiamen Yunfan Biotech Co.,Ltd.
Product
tert-Butyl N-hydroxycarbamate 36016-38-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%+
Supply Ability
1200kg/Month
Release date
2024-05-14
Zibo Hangyu Biotechnology Development Co., Ltd
Product
tert-Butyl N-hydroxycarbamate 36016-38-3
Price
US $70.00-700.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-06
Henan Fengda Chemical Co., Ltd
Product
tert-Butyl N-hydroxycarbamate 36016-38-3
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09

36016-38-3, tert-Butyl N-hydroxycarbamateRelated Search:

Buprofezin Butyl acetate tert-Butyl glycinate tert-Butyl 4-aminobenzoate Butyl formate n-Butyl carbamate tert-Butanol 2-Butoxyethanol Hydroxylamine hydrochloride Hydroxylamine sulfate tert-Butyl carbazate Urethane tert-Butyl peroxybenzoate 4-Aminobenzoic acid N-Carbobenzyloxyglycine 4-Hydroxybenzoic acid Cyhalofop-butyl Methylparaben

  • N-Boc-hydroxylamine, >=98%
  • N-tert-Butoxycarbonylhydroxylamine, 98+%
  • N-(tert-Butoxycarbonyl)hydroxylamine~tert-ButylN-hydroxycarbamate
  • N-(T-BUTOXYCARBONYL)-HYDROXYLAMINE
  • N-T-BOC HYDROXYLAMINE
  • N-HYDROXYCARBAMIC ACID TERT-BUTYL ESTER
  • N-BOC-HYDROXYLAMINE
  • TERT-BUTYL N-HYDROXYCARBAMATE 99.0%
  • N-Boc-Hydroxyamine
  • T-BUTYL N-HYDROXYCARBOMATE (N-BOC HYDROXYLAMINE)
  • T-BUTYL N-HYDROXYCARBOMATE
  • PNB(4R,5S,6S)-3-(diphenyloxy)phosphoryloxy-6[(1R)-1-hydoxyethyl]-4-methyl -7-oxo-1-azabicyclo[3,2,0]hept-2-ene-2-caboxylate(MAP or MVP)
  • (t-Butoxycarbonyl)-hydroxylamine
  • N-t-Butyloxycarbonyl-hydroxylamine
  • N-Boc-hydroxylamine N-(tert-Butoxycarbonyl)hydroxylamine N-Hydroxycarbamic Acid tert-Butyl Ester
  • N-hydroxy-, 1,1-dimethylethyl ester
  • Carbamic acid, hydroxy-, 1,1-dimethylethyl ester
  • (Hydroxyamino)formic acid tert-butyl ester
  • tert-Butyl hydroxycarbamate
  • <i>tert</i>-Butyl <i>N</i>-hydroxycarbamate
  • BOC-HNOH
  • BOC-NH-OH
  • T-BUTYL N-HYDROXYCARBAMATE
  • TERT-BUTYL N-HYDROXYCARBAMATE
  • LABOTEST-BB LT00233206
  • N-(TERT-BUTYLOXYCARBONYL)HYDROXYLAMINE
  • N-TERT-BUTOXYCARBONYLHYDROXYLAMINE
  • BOC-Hydroxylamine Tert-Butyl N-hydroxycarbamate
  • Carbamic acid,N-hydroxy-, 1,1-dimethylethyl ester
  • N-Boc-hydroxylamine≥ 99% (HPLC)
  • N-tert-BOC-Hydroxylamine for synthesis
  • N-(tert-Butoxycarbonyl)hyd
  • BOC hydroxylamine
  • 4-hydroxy-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]butanoic acid
  • n-hydroxycarbamate tert butyl ester
  • tert-ButylN-Hydroxycarbamate&gt
  • N-Boc-hydroxyL
  • N-hydroxycarbamate
  • ert-ButylN-hydroxycarbamate
  • N-tert-Boc-Hydroxylamine
  • 36016-38-3
  • C5H11O3N
  • CH33COCONHOH
  • Hydroxylamines
  • Hydroxylamines (N-Substituted)
  • Building Blocks
  • Organic Building Blocks
  • Nitrogen Compounds
  • Protected Amines
  • Hydroxylamines
  • Hydroxylamines (N-Substituted)
  • Naphthyridine,Quinoline
  • API intermediates
  • INTERMEDIATESOFMEROPENAM
  • 1