ChemicalBook > CAS DataBase List > 1,2,3,4-Tetrahydroquinoline

1,2,3,4-Tetrahydroquinoline

Product Name
1,2,3,4-Tetrahydroquinoline
CAS No.
635-46-1
Chemical Name
1,2,3,4-Tetrahydroquinoline
Synonyms
Tetrahydroquinoline;200g;Kusol;200G/1KG/5KG;1-AZATETRALIN;AURORA KA-684;AKOS BBS-00003596;1,2,3,4-Tetrahydroqu;Py-Tetrahydroquinoline;1,2,3,4-Hydroquinoline
CBNumber
CB7286982
Molecular Formula
C9H11N
Formula Weight
133.19
MOL File
635-46-1.mol
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1,2,3,4-Tetrahydroquinoline Property

Melting point:
9-14 °C (lit.)
Boiling point:
113-117 °C/10 mmHg (lit.) 249 °C (lit.)
Density 
1.061 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.593(lit.)
Flash point:
213 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
Liquid
pka
5.09±0.20(Predicted)
color 
Clear pale yellow to yellow
PH
10-11 (111g/l, H2O, 20℃)(as an emulsion)
Odor
at 1.00 % in dipropylene glycol. honey civet animal phenolic
Odor Type
animal
biological source
synthetic
Water Solubility 
<1 g/L (20 ºC)
FreezingPoint 
11.0 to 20.0 ℃
BRN 
116149
LogP
2.290
CAS DataBase Reference
635-46-1(CAS DataBase Reference)
NIST Chemistry Reference
Quinoline, 1,2,3,4-tetrahydro-(635-46-1)
EPA Substance Registry System
1,2,3,4-Tetrahydroquinoline (635-46-1)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
36/37/38-45
Safety Statements 
26-36/37-36-45-53
WGK Germany 
3
TSCA 
Yes
HS Code 
29334990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
87350
Product name
1,2,3,4-Tetrahydroquinoline
Purity
purum, ≥96.0% (GC)
Packaging
500ml
Price
$108
Updated
2024/03/01
Sigma-Aldrich
Product number
87350
Product name
1,2,3,4-Tetrahydroquinoline
Purity
purum, ≥96.0% (GC)
Packaging
100ml
Price
$55.3
Updated
2023/06/20
TCI Chemical
Product number
T0113
Product name
1,2,3,4-Tetrahydroquinoline
Purity
>95.0%(GC)
Packaging
25mL
Price
$21
Updated
2024/03/01
TCI Chemical
Product number
T0113
Product name
1,2,3,4-Tetrahydroquinoline
Purity
>95.0%(GC)
Packaging
100mL
Price
$41
Updated
2024/03/01
Alfa Aesar
Product number
B22750
Product name
1,2,3,4-Tetrahydroquinoline, 99%
Packaging
100g
Price
$42.65
Updated
2024/03/01
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1,2,3,4-Tetrahydroquinoline Chemical Properties,Usage,Production

Chemical Properties

Clear pale yellow to yellow liquid. It is easily oxidized in air and may acquire a pale amber colour if exposed to air and daylight. Solidifies in the cold.

Uses

1,2,3,4-Tetrahydroquinoline is a reagent used in the synthesis of N-substituted benzoyl-1,2,3,4-tetrahydroquinolyl-1-carboxamides displaying fungicidal activity.

Definition

ChEBI: A member of the class of quinolines that is the 1,2,3,4-tetrahydro derivative of quinoline.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 34, p. 3905, 1986 DOI: 10.1248/cpb.34.3905
Tetrahedron, 52, p. 1631, 1996 DOI: 10.1016/0040-4020(95)00991-4

Synthesis

1,2,3,4-Tetrahydroquinoline is synthesised using quinoline N-oxide as a raw material by chemical reaction. The specific synthesis steps are as follows:
General procedure: In a 1.5 mL reaction vial, B(C6F5)3 (0.025 mmol, 5.0 mol %) was dissolved in chloroform (0.60 mL), towhich diethylsilane (1.75 mmol, 3.5 equiv) was added. After shaking briefly, quinolines (1a-p, 0.50 mmol, 1.0equiv) was subsequently added to the above catalyst solution under argon atmosphere. The reaction mixturewas stirred at 25-65 oC for 6-24 h for the reaction of 1a-h, and at 25-100 oC for 2-24 h for the reaction of 1i-p,then allowed to cool down to room temperature and concentrated under reduced pressure to give the crudeproduct. This reaction mixture was then treated with 0.25 N HCl ethereal solution (7 mL) and stirred at roomtemperature for 1 h to give the solid residue, which was subsequently washed with ether. The solid residue wasthen dissolved or suspended in MeOH (1.0 mL) and neutralized with Na2CO3·H2O (0.5 g) at 0 oC. After stirringfor 2 h, MeOH was removed under reduced pressure, and the neutralized reaction residue was dissolved inCH2Cl2 and washed with brine (5 mL) and water (5 mL). The crude product was then obtained from the organicphase of CH2Cl2 solution and finally purified by column chromatography on silica gel to give 2a-h(EtOAc/Hexane = 1/9) and 2i-p (EtOAc/Hexane = 3/7).

1,2,3,4-Tetrahydroquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2,3,4-Tetrahydroquinoline Suppliers

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View Lastest Price from 1,2,3,4-Tetrahydroquinoline manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
1,2,3,4-Tetrahydroquinoline 635-46-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2024-03-01
WUHAN FORTUNA CHEMICAL CO., LTD
Product
1,2,3,4-Tetrahydroquinoline 635-46-1
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min GC
Supply Ability
1000KGS
Release date
2021-06-28
hebei hongtan Biotechnology Co., Ltd
Product
1,2,3,4-Tetrahydroquinoline 635-46-1
Price
US $80.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
500
Release date
2024-03-20

635-46-1, 1,2,3,4-TetrahydroquinolineRelated Search:

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