ChemicalBook > CAS DataBase List > Estradiol

Estradiol

Product Name
Estradiol
CAS No.
57-91-0
Chemical Name
Estradiol
Synonyms
α-Estradiol;BETA-ESTRADIOL;B-ESTRADIOL;ALPHA-ESTRADIOL;17B-ESTRADIOL;Alfatradiol;17α-estradiol;17A-ESTRADIOL;17ALPHA-ESTRADIOL;Estradiol EP Impurity B
CBNumber
CB7289534
Molecular Formula
C18H24O2
Formula Weight
272.39
MOL File
57-91-0.mol
More
Less

Estradiol Property

Melting point:
176-180 °C(lit.)
alpha 
D20 +53 to +56° (c = 0.9 in dioxane)
Boiling point:
355.44°C (rough estimate)
Density 
1.0708 (rough estimate)
refractive index 
1.4800 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
ethanol: 50 mg/mL, clear, colorless
form 
powder
pka
10.27±0.60(Predicted)
color 
white with slight yellow
Water Solubility 
3.9mg/L(25 ºC)
Merck 
14,3704
CAS DataBase Reference
57-91-0(CAS DataBase Reference)
NIST Chemistry Reference
Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0)
EPA Substance Registry System
Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0)
More
Less

Safety

Hazard Codes 
T,Xn
Risk Statements 
45-48-40
Safety Statements 
53-45-24/25-22
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
RTECS 
KG3750000
F 
8-10
HS Code 
29372390
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H341Suspected of causing genetic defects

H351Suspected of causing cancer

H362May cause harm to breast-fed children

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P273Avoid release to the environment.

P308+P313IF exposed or concerned: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E8750
Product name
α-Estradiol
Purity
powder, ≥98% (TLC)
Packaging
1g
Price
$449.4
Updated
2024/03/01
Sigma-Aldrich
Product number
46542
Product name
α-Estradiol
Purity
VETRANAL
Packaging
100mg
Price
$156
Updated
2024/03/01
Cayman Chemical
Product number
20776
Product name
17α-Estradiol
Purity
≥98%
Packaging
50mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
20776
Product name
17α-Estradiol
Purity
≥98%
Packaging
100mg
Price
$76
Updated
2024/03/01
Sigma-Aldrich
Product number
E8750
Product name
α-Estradiol
Purity
powder, ≥98% (TLC)
Packaging
100mg
Price
$120
Updated
2024/03/01
More
Less

Estradiol Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.

Definition

ChEBI: An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer).

Biological Activity

Endogenous estrogen receptor ligand (K i values are 0.2 and 1.2 nM for ER α and ER β receptors respectively).

Biochem/physiol Actions

Estradiol (known as alpha Estradiol or 17 alpha Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture.17-estradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer′s disease and ischemic stroke.

target

Beta Amyloid | Bcl-2/Bax | Caspase | PARP | Estrogen receptor | GABA Receptor | Progestogen receptor

storage

Room temperature

Purification Methods

17-Estradiol recrystallises from aqueous EtOH (80%) as the hemihydrate and differs from the -anomer (below) by not precipitating with digitonin in 80% aqueous EtOH. The diacetate [1474-52-8] crystallises from aqueous EtOH in needles with m 139-140o. The 3-benzoate crystallises in three forms m 158o, 153o and 63o.

Estradiol Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Estradiol Suppliers

Canada 2 China 248 China Hong Kong 1 Europe 1 France 2 Germany 8 Hungary 1 India 15 Italy 1 Japan 5 Poland 1 Slovakia 1 South Korea 1 Spain 1 Switzerland 1 The Netherlands 1 United Kingdom 6 United States 45 Global 341
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
3868
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Santa Cruz Biotechnology, Inc.
Tel
--
Fax
--
Email
scbt@scbt.com
Country
United States
ProdList
3597
Advantage
60
Altan Corporation
Tel
--
Fax
--
Email
OrderingService@AltanBiochemicals.com
Country
United States
ProdList
1161
Advantage
30
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
Advanced ImmunoChemical Incorporated
Tel
--
Fax
--
Email
etech@advimmmuno.com
Country
United States
ProdList
238
Advantage
71
Worthington Biochemical Corporation
Tel
--
Fax
--
Email
office@worthington-biochem.com
Country
United States
ProdList
109
Advantage
77
Zymed Laboratories Inc.
Tel
--
Fax
--
Country
United States
ProdList
3068
Advantage
86
Assay Designs, Inc.
Tel
--
Fax
--
Email
info@assaydesigns.com
Country
United States
ProdList
47
Advantage
77
C/D/N Isotopes
Tel
--
Fax
--
Email
info@cr200.it
Country
United States
ProdList
386
Advantage
68
Invitrogen Corporation
Tel
--
Fax
--
Email
supplycenters@invitrogen.com
Country
United States
ProdList
86
Advantage
86
Lab Express
Tel
--
Fax
--
Email
sales@labexpress.com
Country
United States
ProdList
1577
Advantage
67
Sciencelab.com, Inc.
Tel
--
Fax
--
Email
accounting@sciencelab.com
Country
United States
ProdList
4159
Advantage
82
www.vwrsp.com
Tel
--
Fax
--
Email
B2B@VWR.com
Country
United States
ProdList
622
Advantage
86
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
EMD Biosciences, Inc.
Tel
--
Fax
--
Email
technical@calbiochem.com
Country
United States
ProdList
6529
Advantage
66
LKT Laboratories, Inc.
Tel
--
Fax
--
Email
info@lktlabs.com
Country
United States
ProdList
2164
Advantage
64
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
Crescent Chemical Co., Inc.
Tel
--
Fax
--
Email
sales@creschem.com
Country
United States
ProdList
4597
Advantage
68
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
Steraloids Inc.
Tel
--
Fax
--
Email
sales@steraloids.com
Country
United States
ProdList
2357
Advantage
68
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
Upstate
Tel
--
Fax
--
Email
info@upstate.com
Country
United States
ProdList
876
Advantage
76
Cerilliant Corporation
Tel
--
Fax
--
Email
techserv@cerilliant.com
Country
United States
ProdList
1629
Advantage
69
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
Research Plus, Inc.
Tel
--
Fax
--
Email
respls@aol.com
Country
United States
ProdList
3674
Advantage
51
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
ChromaDex
Tel
--
Fax
--
Email
sales@chromadex.com
Country
United States
ProdList
2501
Advantage
76
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
More
Less

View Lastest Price from Estradiol manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
17α-Estradiol 57-91-0
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
50kg/month
Release date
2021-06-03
Hangzhou Hyper Chemicals Limited
Product
17-alpha Estradiol 57-91-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
USP, BP, GMP
Supply Ability
5,000KG
Release date
2024-05-08
Wuhan Cell Pharmaceutical Co., Ltd
Product
Estradiol 57-91-0
Price
US $9.90/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2023-05-17

57-91-0, EstradiolRelated Search:

BETA-ESTRADIOL 3-BENZOATE,BETA-ESTRADIOL BENZOATE,B-ESTRADIOL-3-BENZOATE BETA-ESTRADIOL 17-VALERATE EPIMESTROL Inositol Estradiol Cypionate Acid Red 94 Quinestrol β-Estradiol Ethynyl estradiol ESTRADIOL 17-HEPTANOATE,BETA-ESTRADIOL-17-ENANTHATE 1,3,5(10)-ESTRATRIEN-2,3-DIOL-17-ONE 2-METHYL ETHER 3-ACETATE 17-ETHYLENEKETAL (16b,17a)-Estra-1,3,5(10)-triene-3,16,17-triol Oracon 1,3,5(10)-ESTRATRIEN-2,3-DIOL-17-ONE 3-METHYL ETHER 17-ETHYLENEKETAL 17-EPIESTRIOL 17ALPHA-ESTRADIOL-2,4-D2 BETA-ESTRADIOL 3-METHYL ETHER DELTA-9(11)-ESTRADIOL

  • 1,3,5-estratriene-3,17-alpha-diol
  • 1,3,5-Estratriene-3,17alpha-diol
  • 17alpha-Oestradiol
  • 3,17alpha-Dihydroxyestra-1,3,5(10)-triene
  • 3,17-alpha-dihydroxyoestra-1,3,5(10)-triene
  • 3,17alpha-Dihydroxyoestra-1,3,5(10)-triene
  • 5(10)-triene-3,17-diol,(17-alpha)-estra-3
  • epiestradial
  • Estra-1,3,5(10)-triene-3,17alpha-diol
  • Estra-1,3,5(10)-triene-3,17-diol, (17alpha)-
  • Estradiol, 17alpha-
  • Oestra-1,3,5(10)-triene-3,17alpha-diol
  • Oestradiol-17alpha
  • oestradiol-17-alpha
  • Ethinylestradiol Impurity 12（Ethinylestradiol EP Impurity L）
  • 1,3,5(10)-estratriene-3,17α-diol
  • A-ESTRADIOL
  • (8S,9S,13S,14S,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta
  • 17A-ESTRADIOL-CARC USP28
  • 1,3,5-Estratriene-3,17β-diol, 3,17β-Dihydroxy-1,3,5(10)-estratriene
  • C02537
  • α-Estradiol,1,3,5(10)-Estratriene-3,17α-diol, 3,17α-Dihydroxy-1,3,5(10)-estratriene, Epiestradiol
  • 13β-Methyl-1,3,5(10)-gonatriene-3,17α-diol
  • 17-Epiestradiol
  • 17α-Oestradiol
  • 3,17α-Dihydroxyoestra-1,3,5(10)-triene
  • Alfatradiol
  • Epiestrol
  • IMp. L (EP): Estra-1,3,5(10)-triene-3,17a-diol (17a-Estradiol
  • ESTRADIOL, 17a-(P)
  • 17-epi-Estradiol (Estradiol IMpurity B)
  • Epiestradiol 17a-Estradiol
  • 17a-Estradiol solution,100ppm
  • (8R,9S,13S,14S,17R)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
  • Estradiol Impurity 2(Estradiol EP Impurity B)
  • 3-O-Methyl-6-oxo 17&beta
  • 4-Methyl-17&alpha
  • 2-Methoxy-d3 17&beta
  • α-Estradiol 57-91-0
  • 7Α-Estriol
  • 17-O-Acetyl-3-O-methyl-6-oxo 17&beta
  • 2-Bromo 17&beta
  • 4-Methoxy 17&beta
  • Estradiol EP Impurity B
  • 2-Hydroxy-17&beta
  • 4-Carboxyl-17&beta
  • 4-Formyl-17&beta
  • 3-O-Methyl 17&alpha
  • 4-Bromo 17&beta
  • (4-Methyl-d3)-17&alpha
  • 4-Hydroxy-17&beta
  • 2-Formyl-17&beta
  • B-ESTRADIOL
  • BETA-ESTRADIOL
  • CIS-ESTRADIOL
  • EPIESTRADIOL
  • E 2
  • DIOGYN