5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine
- Product Name
- 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine
- CAS No.
- 1225037-39-7
- Chemical Name
- 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine
- Synonyms
- PQR309;CS-2024;PI3K-IN-2;Bimiralisib;PQR-309, >98%;PQR309 Bimiralisib;Bimiralisib (PQR309);PQR309;PQR 309;PQR-309;Bimiralisib (PQR309)(free base);BIMIRALISIB;PQR309;PQR 309;PQR-309
- CBNumber
- CB73039400
- Molecular Formula
- C17H20F3N7O2
- Formula Weight
- 411.38
- MOL File
- 1225037-39-7.mol
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine Property
- Boiling point:
- 643.7±65.0 °C(Predicted)
- Density
- 1.418±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:22.0(Max Conc. mg/mL);53.48(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);24.31(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);4.86(Max Conc. mM) - form
- A crystalline solid
- pka
- 4.92±0.10(Predicted)
- color
- White to gray
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 23441
- Product name
- Bimiralisib
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 23441
- Product name
- Bimiralisib
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $155
- Updated
- 2024/03/01
- Product number
- 23441
- Product name
- Bimiralisib
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $290
- Updated
- 2024/03/01
- Product number
- 23441
- Product name
- Bimiralisib
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $638
- Updated
- 2024/03/01
- Product number
- CS-4672
- Product name
- Bimiralisib
- Purity
- 98.74%
- Packaging
- 100mg
- Price
- $640
- Updated
- 2021/12/16
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine Chemical Properties,Usage,Production
Description
Bimiralisib is a potent and orally bioavailable inhibitor of phosphatidylinositol 3-kinases (PI3Ks; IC50s = 33, 661, 708, and 451 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively) and the mammalian target of rapamycin (mTOR; IC50 = 89 nM). It is selective for these kinases over a panel of cell surface and nuclear receptors, membrane channels, transporters, kinases, proteases, and phosphodiesterases at a concentration of 10 μM. Bimiralisib has anticancer activity with an average GI50 value of 0.7 μM across the National Cancer Institute (NCI) 60 human cancer cell line panel. In vivo, bimiralisib (5-15 mg/kg) reduces tumor growth in a dose-dependent manner in a PC3 prostate cancer mouse xenograft model. Formulations containing bimiralisib are under clinical investigation for the treatment of relapsed and refractory lymphoma and advanced solid tumors.
Uses
Bimiralisib is an orally bioavailable PI3K/mTOR inhibitor for cancer
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine manufacturers
- Product
- 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine 1225037-39-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%~99%
- Supply Ability
- per week 100kg
- Release date
- 2019-09-05