ChemicalBook > CAS DataBase List > 1-(Trifluoroacetyl)imidazole

1-(Trifluoroacetyl)imidazole

Product Name
1-(Trifluoroacetyl)imidazole
CAS No.
1546-79-8
Chemical Name
1-(Trifluoroacetyl)imidazole
Synonyms
TFAI;TRIFLUOROACETYLIMIDAZOLE;TFBI;TrifluorobutyrliMidazole;TrifluorobutyryliMidazole;N-TRIFLUOROACETYLIMIDAZOLE;1-(TRIFLUOROACETYL)IMIDAZOLE;1-(trifluoroacetyl)-1h-imidazole;1-(Trifluoroacetyl)imidazole 98%;N-Trifluoroacetylimidazole, 98+%
CBNumber
CB7308204
Molecular Formula
C5H3F3N2O
Formula Weight
164.09
MOL File
1546-79-8.mol
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1-(Trifluoroacetyl)imidazole Property

Boiling point:
137 °C(lit.)
Density 
1.442 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.424(lit.)
Flash point:
113 °F
storage temp. 
2-8°C
solubility 
sol most common solvents, e.g. ether, THF.
pka
0.78±0.10(Predicted)
form 
clear liquid
color 
Colorless to Yellow to Orange
Specific Gravity
1.442
Water Solubility 
reacts
Sensitive 
Moisture Sensitive
BRN 
608904
CAS DataBase Reference
1546-79-8(CAS DataBase Reference)
NIST Chemistry Reference
N-Trifluoroacetylimidazole(1546-79-8)
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Safety

Hazard Codes 
Xi,F,C
Risk Statements 
10-36/37/38-34-22
Safety Statements 
26-36/37-45-36/37/39-16
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
F 
10-21
Hazard Note 
Flammable/Moisture Sensitive/Keep Cold
TSCA 
T
HazardClass 
3
PackingGroup 
III
HS Code 
29332900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
346128
Product name
1-(Trifluoroacetyl)imidazole
Purity
98%
Packaging
10g
Price
$101
Updated
2025/07/31
Sigma-Aldrich
Product number
346128
Product name
1-(Trifluoroacetyl)imidazole
Purity
98%
Packaging
1g
Price
$31.5
Updated
2023/06/20
TCI Chemical
Product number
T0670
Product name
1-(Trifluoroacetyl)imidazole
Purity
>98.0%(T)
Packaging
5g
Price
$51
Updated
2025/07/31
TCI Chemical
Product number
T0670
Product name
1-(Trifluoroacetyl)imidazole
Purity
>98.0%(T)
Packaging
25g
Price
$257
Updated
2025/07/31
Sigma-Aldrich
Product number
394920
Product name
1-(Trifluoroacetyl)imidazole
Purity
for GC derivatization
Packaging
10x1ml
Price
$331
Updated
2022/05/15
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1-(Trifluoroacetyl)imidazole Chemical Properties,Usage,Production

Chemical Properties

Colorless to pink liquid

Uses

1-(Trifluoroacetyl)imidazole was used as a derivating agent to sequentially derivatize functional groups like amino groups, in a study demonstrating trimethylsilyl esters of aromatic and aliphatic sulfonic acids.

Preparation

N,N′-Carbonyldiimidazole (20.5 g) is dissolved in 100 ml of dry THF and treated dropwise with 28.8 g of Trifluoroacetic Acid in 80 mL of dry THF. The resulting solution is cooled for several hours. Removal of the solvent and distillation of the filtrate gives 14.4 g of material. Alternatively, Imidazole (25.8 g) in 120 mL of dried THF is treated dropwise, with cooling, with 39.9 g of Trifluoroacetic Anhydride in 50 mL of dried THF. Filtration, removal of solvent, and distillation gives 24.8 g of 1-(Trifluoroacetyl)imidazole.

General Description

1-(Trifluoroacetyl)imidazole is a derivatizing reagent.

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations

storage

store under nitrogen, carefully excluding water. Irritant; moisture sensitive; keep cold; flammable.

1-(Trifluoroacetyl)imidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(Trifluoroacetyl)imidazole Suppliers

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View Lastest Price from 1-(Trifluoroacetyl)imidazole manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
1-(Trifluoroacetyl)imidazole 1546-79-8
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2025-09-24
Shaanxi Dideu New Materials Co. Ltd
Product
1-(Trifluoroacetyl)imidazole 1546-79-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2024-11-13
Shaanxi Dideu Medichem Co. Ltd
Product
1-(Trifluoroacetyl)imidazole 1546-79-8
Price
US $0.10/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10
Release date
2024-08-19

1546-79-8, 1-(Trifluoroacetyl)imidazoleRelated Search:

Imidazole Acetyl tributyl citrate Sodium triacetoxyborohydride Methyltriacetoxysilane Triclobendazole FLUOROACETAMIDE 2,2,2-TRIFLUOROETHYLAMINE Trifluoroacetamide 1H-Imidazole-1-carboxaldehyde 1-Acetylimidazole ACETYL FLUORIDE 2-AMINO-5-TRIFLUOROMETHYL-4-TRIFLUOROACETYL-IMIDAZOLE 2,2-DIFLUOROACETAMIDE 2,2-DIFLUOROETHYLAMINE 1-(Trifluoroacetyl)imidazole

  • 1H-Imidazole, 1-(trifluoroacetyl)-
  • N-TRIFLUOROACETYLIMIDAZOLE
  • TRIFLUOROACETYLIMIDAZOLE
  • TFAI
  • 1-(trifluoroacetyl)-1h-imidazole
  • 1-(TRIFLUOROACETYL)IMIDAZOLE
  • 1-(TRIFLUOROACETYL)IMIDAZOLE, DERIVATI-Z ATION REAGENT
  • 1-(Trifluoroacetyl)imidazole, 97.5%, derivatization grade
  • 1-(Trifluoroacetyl)imidazole 98%
  • 2,2,2-Trifluoro-1-(1H-imidazol-1-yl)
  • 1-(TRIFLUOROACETYL)IMIDAZOLE, DERIVATIZA TION GRADE
  • 1H-Imidazole, 1-(trifluoroacetyl)- (9CI)
  • 1-(Trifluoroacetyl)-1H-imidazole 98%
  • 1-(Trifluoroacetyl)-1H-imidazole98%
  • N-Trifluoroacetylimidazole, 98+%
  • Trifluoromethyl(1H-imidazole-1-yl) ketone
  • 1-(Trifluoroacetyl)imidazole,95%
  • 1-(Trifluoroacetyl)imidazole,98%
  • 2,2,2-trifluoro-1-(1H-iMidazol-1-yl)ethan-1-one
  • 2,2,2-trifluoro-1-(1H-iMidazol-1-yl)-Ethanone
  • TFBI
  • TrifluorobutyrliMidazole
  • TrifluorobutyryliMidazole
  • 1-(1H-Imidazol-1-yl)-2,2,2-trifluoroethan-1-one, 2-(1H-Imidazol-1-yl)-2-oxo-1,1,1-trifluoroethane
  • TFAI (N-(trifluoroacetyl) iMidazole)
  • Ethanone, 2,2,2-trifluoro-1-(1H-iMidazol-1-yl)-
  • 1-(Trifluoroacetyl)imidazole &gt
  • 2,2,2-Trifluoro-1-imidazol-1-yl-ethanone
  • TIANFUCHEM--1546-79-8---1-(Trifluoroacetyl)imidazole
  • 2,2,2-Trifluoro-1-(1H-imidazol-1-yl)ethanone,95%
  • 2,2,2-Trifluoro-1-(1H-imidazol-1-yl)ethanone - [T2796]
  • 1546-79-8
  • 1543-79-8
  • H6F3FeO3
  • GC Derivatizing Reagents
  • Protection & Derivatization Reagents (for Synthesis)
  • Acylation (GC Derivatizing Reagents)
  • Acylation Reagent
  • Acylation (GC Derivatizing Reagents)
  • Analytical Chemistry
  • GC Derivatizing Reagents
  • Protection & Derivatization Reagents (for Synthesis)
  • Synthetic Organic Chemistry
  • Building Blocks
  • Acylation ReagentsBuilding Blocks
  • Analytical/Chromatography
  • Derivatization Reagents
  • Heterocyclic Building Blocks
  • Imidazoles
  • Imidazol&Benzimidazole
  • Heterocyclic Compounds
  • ACETYLHALIDE