ChemicalBook > CAS DataBase List > (Z)-Guggulsterone

(Z)-Guggulsterone

Product Name
(Z)-Guggulsterone
CAS No.
95975-55-6
Chemical Name
(Z)-Guggulsterone
Synonyms
GUGGULSTERONE;NSC 37445;Stersterone;GUGULSTERONE;GUGGULSTERONE Z;GUGGULESTERONES;GUGGULESTERONE Z;Coumarin sterone;CIS GUGGULSTERONE;Guggulsterone E&Z
CBNumber
CB7309069
Molecular Formula
C21H28O2
Formula Weight
312.45
MOL File
95975-55-6.mol
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(Z)-Guggulsterone Property

Boiling point:
463.3±45.0 °C(Predicted)
Density 
1.10±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 5 mg/mL
form 
powder
color 
light yellow
CAS DataBase Reference
95975-55-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
37
Safety Statements 
36
WGK Germany 
3
HS Code 
29147000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
G852003
Product name
Z/E-Guggulsterone
Packaging
10mg
Price
$95
Updated
2021/12/16
Biosynth Carbosynth
Product number
FG41868
Product name
(Z&E)-Guggulsterone
Packaging
10g
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-0029421
Product name
Guggulsterone
Purity
99.81%
Packaging
5mg
Price
$70
Updated
2021/12/16
Biosynth Carbosynth
Product number
FG41868
Product name
(Z&E)-Guggulsterone
Packaging
25g
Price
$100
Updated
2021/12/16
ApexBio Technology
Product number
B6925
Product name
Guggulsterone
Packaging
5mg
Price
$110
Updated
2021/12/16
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(Z)-Guggulsterone Chemical Properties,Usage,Production

Uses

Guggulsterone is a broad spectrum steroid receptor ligand. Gum resin of Commiphora mukul marketed as an antihyperlipidemic drug.

Definition

ChEBI: Guggulsterone is a 3-hydroxy steroid. It has a role as an androgen.

Biological Activity

Broad spectrum steroid receptor ligand; binds with high affinity to mineralocorticoid receptors (K i = 39 nM) and lower affinity to progesterone, androgen and glucocorticoid receptors (K i values are 201, 240 and 224 nM respectively). Functions primarily as an antagonist of these receptors, with the exception of the progesterone receptor where it displays partial agonist effects. Also exerts hypolipidemic activity, likely via antagonism of the receptor for bile acids (farnesoid X receptor; FXR).

in vivo

Guggulsterone (orally; 100 mg/kg once per day for 8 days) significantly improved the survival rates of wild-type mice with TNBS-induced colitis[2].

Animal Model:Wild-type mice with TNBS-induced colitis[2]
Dosage:100 mg/kg
Administration:Orally; once per day; for 8 days
Result:Improved the survival rates of wild-type mice with TNBS-induced colitis.

IC 50

JNK; Caspase

(Z)-Guggulsterone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (Z)-Guggulsterone manufacturers

Wuhan Senwayer Century Chemical Co.,Ltd
Product
Guggulsterone 95975-55-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99% min
Supply Ability
20 tons
Release date
2024-12-12
Career Henan Chemical Co
Product
(Z)-Guggulsterone 95975-55-6
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
10kg
Release date
2018-12-18

95975-55-6, (Z)-GuggulsteroneRelated Search:

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