ChemicalBook > CAS DataBase List > (Z)-Guggulsterone
(Z)-Guggulsterone
- Product Name
- (Z)-Guggulsterone
- CAS No.
- 95975-55-6
- Chemical Name
- (Z)-Guggulsterone
- Synonyms
- GUGGULSTERONE;NSC 37445;Stersterone;GUGULSTERONE;GUGGULSTERONE Z;GUGGULESTERONES;GUGGULESTERONE Z;Coumarin sterone;CIS GUGGULSTERONE;Guggulsterone E&Z
- CBNumber
- CB7309069
- Molecular Formula
- C21H28O2
- Formula Weight
- 312.45
- MOL File
- 95975-55-6.mol
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(Z)-Guggulsterone Property
- Boiling point:
- 463.3±45.0 °C(Predicted)
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 5 mg/mL
- form
- powder
- color
- light yellow
- CAS DataBase Reference
- 95975-55-6(CAS DataBase Reference)
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N-Bromosuccinimide Price
TRC
- Product number
- G852003
- Product name
- Z/E-Guggulsterone
- Packaging
- 10mg
- Price
- $95
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FG41868
- Product name
- (Z&E)-Guggulsterone
- Packaging
- 10g
- Price
- $50
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0029421
- Product name
- Guggulsterone
- Purity
- 99.81%
- Packaging
- 5mg
- Price
- $70
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FG41868
- Product name
- (Z&E)-Guggulsterone
- Packaging
- 25g
- Price
- $100
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B6925
- Product name
- Guggulsterone
- Packaging
- 5mg
- Price
- $110
- Updated
- 2021/12/16
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(Z)-Guggulsterone Chemical Properties,Usage,Production
Uses
Guggulsterone is a broad spectrum steroid receptor ligand. Gum resin of Commiphora mukul marketed as an antihyperlipidemic drug.
Definition
ChEBI: Guggulsterone is a 3-hydroxy steroid. It has a role as an androgen.
Biological Activity
Broad spectrum steroid receptor ligand; binds with high affinity to mineralocorticoid receptors (K i = 39 nM) and lower affinity to progesterone, androgen and glucocorticoid receptors (K i values are 201, 240 and 224 nM respectively). Functions primarily as an antagonist of these receptors, with the exception of the progesterone receptor where it displays partial agonist effects. Also exerts hypolipidemic activity, likely via antagonism of the receptor for bile acids (farnesoid X receptor; FXR).
in vivo
Guggulsterone (orally; 100 mg/kg once per day for 8 days) significantly improved the survival rates of wild-type mice with TNBS-induced colitis[2].
| Animal Model: | Wild-type mice with TNBS-induced colitis[2] |
| Dosage: | 100 mg/kg |
| Administration: | Orally; once per day; for 8 days |
| Result: | Improved the survival rates of wild-type mice with TNBS-induced colitis. |
IC 50
JNK; Caspase
(Z)-Guggulsterone Preparation Products And Raw materials
Raw materials
Preparation Products
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(Z)-Guggulsterone Suppliers
- Tel
- --
- Fax
- --
- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91
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View Lastest Price from (Z)-Guggulsterone manufacturers
Wuhan Senwayer Century Chemical Co.,Ltd
- Product
- Guggulsterone 95975-55-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99% min
- Supply Ability
- 20 tons
- Release date
- 2024-12-12
Career Henan Chemical Co
- Product
- (Z)-Guggulsterone 95975-55-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 10kg
- Release date
- 2018-12-18
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