2,5-Difluorobenzaldehyde
- Product Name
- 2,5-Difluorobenzaldehyde
- CAS No.
- 2646-90-4
- Chemical Name
- 2,5-Difluorobenzaldehyde
- Synonyms
- TIMTEC-BB SBB006570;2,5-Difluorobenzalde;Difluorobenzaldehyde;2,5-fluorobenzaldehyde;2-CHLORO-4-ETHOXYANILINE;2,5-DIFLUOROBENZALDEHYDE;2,9-Difluoroacetophenone;2,5-Difluoro Benzaldehydes;2,5-Difluorobenzaldehyde>2,5-Difluorobenzaldehyde98%
- CBNumber
- CB7310342
- Molecular Formula
- C7H4F2O
- Formula Weight
- 142.1
- MOL File
- 2646-90-4.mol
2,5-Difluorobenzaldehyde Property
- Melting point:
- 67-69 °C
- Boiling point:
- 67-69 °C/17 mmHg (lit.)
- Density
- 1.308 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.498(lit.)
- Flash point:
- 138 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Liquid
- Specific Gravity
- 1.308
- color
- Clear colorless to yellow
- Sensitive
- Air Sensitive
- BRN
- 2573664
- InChI
- InChI=1S/C7H4F2O/c8-6-1-2-7(9)5(3-6)4-10/h1-4H
- InChIKey
- VVVOJODFBWBNBI-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC(F)=CC=C1F
- CAS DataBase Reference
- 2646-90-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39-36/37
- RIDADR
- UN 1989 3/PG 3
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 3.2
- PackingGroup
- III
- HS Code
- 29130000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 265187
- Product name
- 2,5-Difluorobenzaldehyde
- Purity
- 98%
- Packaging
- 5g
- Price
- $48.8
- Updated
- 2025/07/31
- Product number
- 265187
- Product name
- 2,5-Difluorobenzaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $31.6
- Updated
- 2023/06/20
- Product number
- D2637
- Product name
- 2,5-Difluorobenzaldehyde
- Purity
- >96.0%(GC)
- Packaging
- 5g
- Price
- $48
- Updated
- 2025/07/31
- Product number
- D2637
- Product name
- 2,5-Difluorobenzaldehyde
- Purity
- >96.0%(GC)
- Packaging
- 25g
- Price
- $144
- Updated
- 2025/07/31
- Product number
- 265187
- Product name
- 2,5-Difluorobenzaldehyde
- Purity
- 98%
- Packaging
- 25g
- Price
- $92.3
- Updated
- 2023/06/20
2,5-Difluorobenzaldehyde Chemical Properties,Usage,Production
Chemical Properties
clear light yellow liquid
Uses
2,5-Difluorobenzaldehyde was used in the synthesis of fluorinated analog by Henry condensation with nitroethane.
General Description
The emission and absorption spectra of 2,5-difluorobenzaldehyde were studied.
Synthesis
540-36-3
93-61-8
2646-90-4
Example 3 Synthesis of 2,5-difluorobenzaldehyde Procedure: to a stirred solution of 194.5 g (1.70 mol) of 1,4-difluorobenzene dissolved in 2 ml of anhydrous tetrahydrofuran was added dropwise 1.70 mol (2.2 M hexane solution) of n-butyllithium at -60°C, at a rate maintaining the temperature below -55°C. The reaction mixture was stirred below -50°C for 45 minutes, followed by continued stirring in the range of -50°C to -45°C for 1.5 hours. The solution was cooled to -30°C and 230 g of N-methylformanilide dissolved in 300 ml of tetrahydrofuran was added dropwise over 30 minutes. The mixture was stirred at -50°C for 1 hour, followed by a slow warming to -30°C over 15 minutes. The reaction mixture was poured into ice water and neutralized to pH 6-7 with 10% sulfuric acid solution, followed by three extractions with hexane. The combined organic phases were sequentially washed once each with 1N sulfuric acid solution and saturated sodium chloride solution and concentrated to give an oil. Purification by reduced pressure distillation (64°-65°C, 20 mm Hg) gave 187.5 g (77.5%) of 2,5-difluorobenzaldehyde.
References
[1] Patent: US4654336, 1987, A
2,5-Difluorobenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,5-Difluorobenzaldehyde manufacturers
- Product
- 2,5-Difluorobenzaldehyde 2646-90-4
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-19
- Product
- 2,5-Difluorobenzaldehyde 2646-90-4
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-08-03
- Product
- 2,5-Difluorobenzaldehyde 2646-90-4
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2018-08-15