ChemicalBook > CAS DataBase List > Itopride hydrochloride

Itopride hydrochloride

Product Name: Itopride hydrochloride
CAS No.: 122892-31-3
Chemical Name: Itopride hydrochloride
Synonyms: Itax;HC-803;Ganato;hsr803;Ganaton;ITOPRIDE HCL;ITOPRIDE HYDROCHLORIDE;ltopride Hydrochloride;Itopride Hydrochloride >Itopride Hydrochloride - API
CBNumber: CB7310786
Molecular Formula: C20H27ClN2O4
Formula Weight: 394.89
MOL File: 122892-31-3.mol

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Itopride hydrochloride Property

Melting point:: 194-1950C
storage temp.: 2-8°C
solubility: H2O: ≥48mg/mL
form: powder
color: white to tan
Water Solubility: H2O: ≥48mg/mL
λmax: 258nm(MeOH)(lit.)
Merck: 14,5244
InChI: InChI=1S/C20H26N2O4.ClH/c1-22(2)11-12-26-17-8-5-15(6-9-17)14-21-20(23)16-7-10-18(24-3)19(13-16)25-4;/h5-10,13H,11-12,14H2,1-4H3,(H,21,23);1H
InChIKey: ZTOUXLLIPWWHSR-UHFFFAOYSA-N
SMILES: C1(C(=O)NCC2=CC=C(OCCN(C)C)C=C2)=CC=C(OC)C(OC)=C1.Cl
CAS DataBase Reference: 122892-31-3(CAS DataBase Reference)

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Safety

Hazard Codes: N
Risk Statements: 50
Safety Statements: 61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
RTECS: CV4552000
HS Code: 2924.29.7790

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0033
Product name: Itopride hydrochloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $120
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0033
Product name: Itopride hydrochloride
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $448.4
Updated: 2025/07/31

TCI Chemical

Product number: I0948
Product name: Itopride Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $27
Updated: 2025/07/31

TCI Chemical

Product number: I0948
Product name: Itopride Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $82
Updated: 2025/07/31

TRC

Product number: I931500
Product name: Itopride Hydrochloride
Packaging: 10mg
Price: $85
Updated: 2021/12/16

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Itopride hydrochloride Chemical Properties,Usage,Production

Description

Itopride, a gastroprokinetic benzamide derivative was launched in Japan for the relief of gastrointestinal symptoms in patients with chronic gastritis. ltopride is a dopamine D₂-receptor antagonist that stimulates acetylcholine (Ach) release on the postganglionic cholinergic neurons to cause Ach accumulation at muscarinic receptors and, therefore, enhances Ach-induced gastric contractions. In animal models, itopride was reported to increase GI transit and gastric emptying.

Chemical Properties

Crystalline Solid

Originator

Hokuriku (Japan)

Uses

Dopamine D2-receptor antagonist with anticholinesterase activity. Gastroprokinetic

Uses

Dopamine D2 receptor blockade,acetylcholinesterase inhibitor

Uses

Anti-Spasmodics

brand name

Ganaton

General Description

Itopride hydrochloride is a new prokinetic drug.

Biochem/physiol Actions

Itopride hydrochloride enhances the gastrointestinal motility by blocking the activity of dopamine on the D2 receptors, on the post-synaptic cholinergic nerves and by inducing the liberation of acetylcholine in the myenteric plexus. It also inhibits the hydrolysis of the released acetylcholine with the help of acetylcholinesterase.

Synthesis

122898-67-3

122892-31-3

The general procedure for the synthesis of N-(4-(2-(dimethylamino)ethoxy)benzyl)-3,4-dimethoxybenzamide hydrochloride using etopride as a raw material is as follows: 16 kg of dry etopride and 56 kg of sec-butanol from Example 4 were added to a reactor and heated to 50-55°C until completely dissolved. 4.8 kg of 37% hydrochloric acid solution was added slowly and dropwise, during which the pH of the reaction mixture was monitored to ensure that it was below 2.0. The reaction mixture was stirred continuously at 50-55°C for at least 30 minutes. The mixture was then cooled to 15-25 °C and centrifuged. The precipitate was washed with 16.0 kg of sec-butanol. Finally, the product was dried at 70-80 °C to obtain 16.5 kg of itopride hydrochloride with HPLC purity of more than 99.8%. The yield of the reaction was 93.7% compared to etopride.

in vitro

itopride was found to inhibit both ache and horse serum butyrylcholinesterase (buche). the itopride ic50 against ache was, however, 100-fold less than that against buche. the recovery of ache activity inhibited by low dose of neostigmine was partial, but that inhibited by itopride was complete. double reciprocal plots showed that both vmax and km were affected by itopride, indicating a "mixed" type inhibition, although primarily being an uncompetitive one. in addition, the inhibitory effect of itopride on cholinesterase (che) activity in guinea pig gastrointestine was much weaker than that on pure ache [1].

in vivo

previoius animal study showed that in conscious dogs with implanted strain gauge force transducers, itopride could stimulate contractile activity in the gastrointestinal tract from stomach to colon. whereas, mosapride was able to stimulate contractile activity only in the gastric antrum and ileum. moreover, in rats s andguinea pig, itopride could accelerate colonic luminal transit, however, both mosapride and cisapride failed to enhance colonic transit. such findings suggested that itopride had a stimulatory action on propelling colonic luminal contents, colonic peristalsis, which was quite different from mosapride and cisapride [2].

IC 50

2.04 μm

References

[1] iwanaga y,kimura t,miyashita n,morikawa k,nagata o,itoh z,kondo y. characterization of acetylcholinesterase-inhibition by itopride. jpn j pharmacol.1994 nov;66(3):317-22.
[2] tsubouchi t,saito t,mizutani f,yamauchi t,iwanaga y. stimulatory action of itopride hydrochloride on colonic motor activity in vitro and in vivo. j pharmacol exp ther.2003 aug;306(2):787-93.

Itopride hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Itopride hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Itopride hydrochloride 122892-31-3
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%min HPLC
Supply Ability: 100KGS
Release date: 2021-07-23

Baoji Guokang Healthchem Co., Ltd.

Product: Itopride hydrochloride 122892-31-3
Price: US $476.00/KG
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 1000KG
Release date: 2021-06-08

Hebei Chuanghai Biotechnology Co., Ltd

Product: Itopride Hydrochloride 122892-31-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10mt
Release date: 2025-03-10

122892-31-3, Itopride hydrochlorideRelated Search:

Tiapride hydrochloride Tribenuron methyl Topotecan hydrochloride PHENYL VALERATE Kresoxim-methyl METSULFURON METHYL Dimethylamine hydrochloride Chlorantraniliprole Benzamide 4-Dimethylaminobenzaldehyde Methyl salicylate EPINASTINE HYDROCHLORIDE Dimethoxymethane Thiophanate-methyl Methyl Ethambutol dihydrochloride Eperisone hydrochloride Etilefrine hydrochloride

hsr803

n-((4-(2-(dimethylamino)ethoxy)phenyl)methyl)-3,4-dimethoxybenzamidemonohydr

n-((4-(2-(dimethylamino)ethoxy)phenyl)methyl)-3,4-dimethoxy-benzamidmonohy

n-((4-(2-(dimethylamino)ethoxy)phenyl)methyl)-3,4-dimethoxy-benzamidmonohydrochloride

n-(4-(2-(dimethylamino)ethoxy)benzyl)-3,4-dimethoxidebenzamidehydrochloride

n-[[4-(2-dimethylaminoethoxy)phenyl]methyl]-3,4-dimethoxy-benzamide hydrochloride

ITOPRIDE HCL

ITOPRIDE HYDROCHLORIDE

Ganato

HC-803

Itax

N-(4-(2-(dimethylamino)ethoxy)benzyl)-3,4-dimethoxybenzmide

N-[4-(2-Dimethylaminoethoxy)benzyl]-3,4-

N-[4-(2-Dimethylaminoethoxy)benzyl]-3,4-dimethoxybenzamidehydrochloride

N-[4-(2-DIMETHYLAMINOETHOXY)BENZYL]-3,4-DIMETHOXYBENZAMIDE HCL

Ganaton

BenzaMide,N-[[4-[2-(diMethylaMino)ethoxy]phenyl]Methyl]-3,4-diMethoxy-, hydrochloride(1:1)

N-[p-[2-(dimethylamino)ethoxy]benzyl]veratramide hydrochloride

Itopride HydrochlorideItopride

Itopride Hydrochloride &gt

Itopride hydrochloride USP/EP/BP

ltopride Hydrochloride

Itopride HydrochlorideQ: What is Itopride Hydrochloride Q: What is the CAS Number of Itopride Hydrochloride Q: What is the storage condition of Itopride Hydrochloride Q: What are the applications of Itopride Hydrochloride

Itopride Hydrochloride - API

Itopride Hydrochloride, ≥ 98.0%

Itopride hydrochloride, 10 mM in DMSO

122892-31-3

C20H27ClN2O4

C20H26N2O4HCl

C20H26N2O4ClH

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