Chrysin

ChemicalBook > CAS DataBase List > Chrysin

Product Name: Chrysin
CAS No.: 480-40-0
Chemical Name: Chrysin
Synonyms: 5,7-DIHYDROXYFLAVONE;5,7-Dihydroxy-2-phenyl-4H-chromen-4-one;Crysin;CHRYSINE;hrysin;CHRYSIN;NSC 407436;Chrysin-RM;CHRYSIN(RG);Chrysin >
CBNumber: CB7312472
Molecular Formula: C15H10O4
Formula Weight: 254.24
MOL File: 480-40-0.mol

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Chrysin Property

Melting point:: 284-286 °C(lit.)
Boiling point:: 357.45°C (rough estimate)
Density: 1.2693 (rough estimate)
refractive index: 1.4872 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 6.50±0.40(Predicted)
form: Crystalline Powder
color: Yellow
λmax: 348 nm
Merck: 14,2256
BRN: 233276
Stability:: Stable. Incompatible with strong oxidizing agents.
InChIKey: RTIXKCRFFJGDFG-UHFFFAOYSA-N
LogP: 3.520
CAS DataBase Reference: 480-40-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-36-26
WGK Germany: 3
RTECS: LK8329050
F: 10
HazardClass: IRRITANT
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C80105
Product name: Chrysin
Purity: 97%
Packaging: 25g
Price: $161
Updated: 2024/03/01

Sigma-Aldrich

Product number: 95082
Product name: Chrysin
Purity: analytical standard
Packaging: 50mg
Price: $132
Updated: 2024/03/01

TCI Chemical

Product number: C1652
Product name: Chrysin
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $87
Updated: 2024/03/01

Alfa Aesar

Product number: L14178
Product name: 5,7-Dihydroxyflavone, 98%
Packaging: 5g
Price: $36.65
Updated: 2024/03/01

Alfa Aesar

Product number: L14178
Product name: 5,7-Dihydroxyflavone, 98%
Packaging: 25g
Price: $121
Updated: 2024/03/01

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Chrysin Chemical Properties,Usage,Production

Description

Chrysin is a natural flavonoid with antioxidant, anti-inflammatory, and anticancer properties. It blocks COX-2 gene expression, PGE2 production, and hydroxyl radical formation in LPS-induced RAW 264.7 cells. Chrysin inhibits insulin-induced HIF-1α expression (~50% at 10 μM) in human prostate cancer DU145 cells and blocks DU145 xenograft-induced angiogenesis in vivo. In a mouse model of ischemia/reperfusion injury, chrysin decreased pro-inflammatory gene expression and oxidative stress, resulting in a reduction of infarct volume and neurological defects.

Chemical Properties

beige powder or Pale yellow prismatic crystal (crystallized from methanol) with a melting point of 285°C. This substance is soluble in alkali hydroxide solution and acetone, slightly soluble in ether, ethanol and chloroform, insoluble in water.

Uses

Chrysin is a flavanoid with anti-inflammatory effect and potential protective effects against cancer and cardiovascular disease. Studies show that Chrysin is central benzodiazepine receptor ligand with possible anxiolytic effects. Chrysin was initially believed to have aromatase inhibitor but recent in vivo studies have disproved that. Dyes and metabolites.

Definition

ChEBI: Chrysin is a dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7. It has a role as an anti-inflammatory agent, an antineoplastic agent, an antioxidant, a hepatoprotective agent, an EC 2.7.11.18 (myosin-light-chain kinase) inhibitor and a plant metabolite. It is a dihydroxyflavone and a 7-hydroxyflavonol.

Biological Functions

Chrysin, also referred to as 5,7-dihydroxyflavone, is a naturally occurring antioxidant flavonoi. It holds immense potential for diverse applications and is being investigated as a potential therapeutic agent for various conditions and diseases. Research on chrysin has revealed its antioxidant, anti-inflammatory, anti-cancer, and anti-diabetic properties, along with its ability to modulate the activity of specific enzymes, hormones, and neurotransmitters. Its therapeutic potential extends to areas like oncology, diabetes, and neurological disorders. Although the precise mechanism of action of chrysin is not yet fully comprehended, research suggests its ability to modulate the activity of enzymes, hormones, and neurotransmitters. For instance, it has shown the potential to influence the activity of aromatase, an enzyme involved in estrogen production. Moreover, chrysin has exhibited inhibitory effects on cancer cell growth and inflammation by influencing the activity of specific enzymes and hormones. It was discovered that Chrysin inhibits HIF-1α (hypoxia-inducible factor-1α) and induces apoptosis.

target

NOS | COX | TNF-α | PGE | IL Receptor | PI3K | Akt | Caspase | NF-kB | TGF-β/Smad

Source

The main sources of chrysin are honey and propolis, of which the content of chrysin in honey is 5.3 mg/kg and that in propolis is 28 g/L. In addition, chrysin is also found in various vegetables, fruits, herbs, and even mushrooms. Another source of populin is an endophytic fungus Chaetomium globosum, which is related to Chaetomorpha media from India. In addition, chrysin exists in the form of glycosides in walnut, walnut skin, walnut flower and pericarp passion fruit, and in the form of 6-c-arabinoside-8-c-glucoside or glucuronic acid ester in Pinellia ternata.

Chrysin Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Phloroglucinol dihydrate Benzoyl chloride

Preparation Products

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Chrysin Suppliers

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View Lastest Price from Chrysin manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Chrysin 480-40-0
Price: US $50.00-10.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 5000kg/ week
Release date: 2024-04-23

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Chrysin 480-40-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 500kg/month
Release date: 2023-01-10

Baoji Guokang Bio-Technology Co., Ltd.

Product: Chrysin 480-40-0
Price: US $255.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10000KG
Release date: 2021-06-02

480-40-0, ChrysinRelated Search:

Benzo[b]thien-2-ylboronic acid 2,2-Bis(hydroxymethyl)butyric acid 1,3-Dihydroxyacetone (ethylenedioxy)dimethanol FLAVONE 3-Diethylaminophenol PHENYL VALERATE Triclosan 1-Hydroxyethylidene-1,1-diphosphonic acid Butylated Hydroxytoluene 7-HYDROXYFLAVONE 2,2-Bis(hydroxymethyl)propionic acid 1-Octacosanol D-Pinitol Evodiamine AVICULARIN MORIN Phenylacetic acid

AKOS NCG1-0026

5,7-DIHYDROXYFLAVONE

5,7-dihydroxy-2-phenyl-4h-benzo[b]pyran-4-one

5,7-DIHYDROXY-2-PHENYL-CHROMEN-4-ONE

LABOTEST-BB LT00440772

CHRYSIN

CHRYSINE

Chrysin 99.0%min

CHRYSIN (5,7-HYDROXYFLAVONE)

Chrysin Extract

4H-1-Benzopyran-4-one,5,7-dihydroxy-2-phenyl-

Chrysidenon 1438

5,7-Dihydroxy-2-phenyl-4H-chromen-4-one

Chrysin, 99+% 25GR

Chrysin, 99+% 5GR

Crysin

NSC 407436

Chrysin (6CI)

5,7-dihydroxy-2-phenyl-4h-1-benzopyran-4-one

5,7-dihydroxy-flavon

Chrysin, 99+%

CHRYSIN(RG)

5,7-DIHYDROXYFLAVONE(CHRYSIN)

Chrysin 5,7-

Chrysinic acid

Chrysin-5,7-dihydroxy

Nano Liposomal 5,7-Dihydroxyflavone

5,7-dihydroxy-2-phenyl-1-benzopyran-4-one

Chrysin 480-40-0

Flavone, 5,7-dihydroxy- (7CI,8CI)

hrysin

5,7-Dihydroxyflavone 5,7-Dihydroxy-2-phenyl-4H-benzo[b]pyran-4-one

5,7-dihydroxy-2-phenyl-4h-1-benzopyran-4-on

Chrysin &gt

Chrysin Powder Extract

5, 7-Dihydroxyflavone 480-40-0 Chrysin

1,2,3,4-TETRAHYDRO-1,1,4,4-TETRAMETHYLNAPHTHALENE 6683-46-1

Chrysin 99%min

CHRYSIN(P) 100mg

CHRYSIN(P) 10mg

CHRYSIN(P) 500mg

Chrysin-RM

Chrysin, Antioxidant flavonoid

480-40-0

48-40-0

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