ChemicalBook > CAS DataBase List > Chrysin

Chrysin

Product Name
Chrysin
CAS No.
480-40-0
Chemical Name
Chrysin
Synonyms
5,7-DIHYDROXYFLAVONE;5,7-Dihydroxy-2-phenyl-4H-chromen-4-one;Crysin;CHRYSINE;hrysin;CHRYSIN;NSC 407436;Chrysin-RM;CHRYSIN(RG);Chrysin >
CBNumber
CB7312472
Molecular Formula
C15H10O4
Formula Weight
254.24
MOL File
480-40-0.mol
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Chrysin Property

Melting point:
284-286 °C(lit.)
Boiling point:
357.45°C (rough estimate)
Density 
1.2693 (rough estimate)
refractive index 
1.4872 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
6.50±0.40(Predicted)
form 
Crystalline Powder
color 
Yellow
Merck 
14,2256
BRN 
233276
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
RTIXKCRFFJGDFG-UHFFFAOYSA-N
LogP
3.520
CAS DataBase Reference
480-40-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
3
RTECS 
LK8329050
F 
10
HazardClass 
IRRITANT
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C80105
Product name
Chrysin
Purity
97%
Packaging
25g
Price
$161
Updated
2024/03/01
Sigma-Aldrich
Product number
95082
Product name
Chrysin
Purity
analytical standard
Packaging
50mg
Price
$132
Updated
2024/03/01
TCI Chemical
Product number
C1652
Product name
Chrysin
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$87
Updated
2024/03/01
Alfa Aesar
Product number
L14178
Product name
5,7-Dihydroxyflavone, 98%
Packaging
5g
Price
$36.65
Updated
2024/03/01
Alfa Aesar
Product number
L14178
Product name
5,7-Dihydroxyflavone, 98%
Packaging
25g
Price
$121
Updated
2024/03/01
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Chrysin Chemical Properties,Usage,Production

Description

Chrysin is a natural flavonoid with antioxidant, anti-inflammatory, and anticancer properties. It blocks COX-2 gene expression, PGE2 production, and hydroxyl radical formation in LPS-induced RAW 264.7 cells. Chrysin inhibits insulin-induced HIF-1α expression (~50% at 10 μM) in human prostate cancer DU145 cells and blocks DU145 xenograft-induced angiogenesis in vivo. In a mouse model of ischemia/reperfusion injury, chrysin decreased pro-inflammatory gene expression and oxidative stress, resulting in a reduction of infarct volume and neurological defects.

Chemical Properties

beige powder or Pale yellow prismatic crystal (crystallized from methanol) with a melting point of 285°C. This substance is soluble in alkali hydroxide solution and acetone, slightly soluble in ether, ethanol and chloroform, insoluble in water.

Uses

Chrysin is a flavanoid with anti-inflammatory effect and potential protective effects against cancer and cardiovascular disease. Studies show that Chrysin is central benzodiazepine receptor ligand with possible anxiolytic effects. Chrysin was initially believed to have aromatase inhibitor but recent in vivo studies have disproved that. Dyes and metabolites.

Definition

ChEBI: Chrysin is a dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7. It has a role as an anti-inflammatory agent, an antineoplastic agent, an antioxidant, a hepatoprotective agent, an EC 2.7.11.18 (myosin-light-chain kinase) inhibitor and a plant metabolite. It is a dihydroxyflavone and a 7-hydroxyflavonol.

Biological Functions

Chrysin, also referred to as 5,7-dihydroxyflavone, is a naturally occurring antioxidant flavonoi. It holds immense potential for diverse applications and is being investigated as a potential therapeutic agent for various conditions and diseases. Research on chrysin has revealed its antioxidant, anti-inflammatory, anti-cancer, and anti-diabetic properties, along with its ability to modulate the activity of specific enzymes, hormones, and neurotransmitters. Its therapeutic potential extends to areas like oncology, diabetes, and neurological disorders. Although the precise mechanism of action of chrysin is not yet fully comprehended, research suggests its ability to modulate the activity of enzymes, hormones, and neurotransmitters. For instance, it has shown the potential to influence the activity of aromatase, an enzyme involved in estrogen production. Moreover, chrysin has exhibited inhibitory effects on cancer cell growth and inflammation by influencing the activity of specific enzymes and hormones. It was discovered that Chrysin inhibits HIF-1α (hypoxia-inducible factor-1α) and induces apoptosis.

target

NOS | COX | TNF-α | PGE | IL Receptor | PI3K | Akt | Caspase | NF-kB | TGF-β/Smad

Source

The main sources of chrysin are honey and propolis, of which the content of chrysin in honey is 5.3 mg/kg and that in propolis is 28 g/L. In addition, chrysin is also found in various vegetables, fruits, herbs, and even mushrooms. Another source of populin is an endophytic fungus Chaetomium globosum, which is related to Chaetomorpha media from India. In addition, chrysin exists in the form of glycosides in walnut, walnut skin, walnut flower and pericarp passion fruit, and in the form of 6-c-arabinoside-8-c-glucoside or glucuronic acid ester in Pinellia ternata.

Chrysin Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Phloroglucinol dihydrate Benzoyl chloride

Preparation Products

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Chrysin Suppliers

Americas 1 Australia 1 Belgium 1 Canada 5 China 494 Czech Republic 1 Europe 4 France 2 Germany 11 India 14 Japan 3 Poland 1 Slovakia 1 Spain 1 Switzerland 5 United Kingdom 13 United States 64 Global 622
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View Lastest Price from Chrysin manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Chrysin 480-40-0
Price
US $50.00-10.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
5000kg/ week
Release date
2024-04-23
BINBO BIOLOGICAL CO.,LTD
Product
Chrysin 480-40-0
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000 kg
Release date
2024-11-27
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Chrysin 480-40-0
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
500kg/month
Release date
2023-01-10

480-40-0, ChrysinRelated Search:

Benzo[b]thien-2-ylboronic acid 2,2-Bis(hydroxymethyl)butyric acid 1,3-Dihydroxyacetone (ethylenedioxy)dimethanol FLAVONE 3-Diethylaminophenol PHENYL VALERATE Triclosan 1-Hydroxyethylidene-1,1-diphosphonic acid Butylated Hydroxytoluene 7-HYDROXYFLAVONE 2,2-Bis(hydroxymethyl)propionic acid 1-Octacosanol D-Pinitol Evodiamine AVICULARIN MORIN Phenylacetic acid

  • AKOS NCG1-0026
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  • Nano Liposomal 5,7-Dihydroxyflavone
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  • Chrysin Powder Extract
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  • 1,2,3,4-TETRAHYDRO-1,1,4,4-TETRAMETHYLNAPHTHALENE 6683-46-1
  • Chrysin 99%min
  • CHRYSIN(P) 100mg
  • CHRYSIN(P) 10mg
  • CHRYSIN(P) 500mg
  • Chrysin-RM
  • 480-40-0
  • 48-40-0
  • Food & Beverage Standards
  • Food Residue Analysis
  • Chromatography
  • Enzyme Inhibitors
  • Flavonoids
  • Chemopreventive Agents
  • Cancer Research
  • Analytical Standards
  • BioChemical
  • Analytical Chromatography Product Catalog
  • chemical reagent
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  • standardized herbal extract