ChemicalBook > CAS DataBase List > 7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE

7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE

Product Name
7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE
CAS No.
75450-34-9
Chemical Name
7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE
Synonyms
CGP;CGP 37157;CGP-37157 ，E0002;CGP37157, 10 mM in DMSO;1-benzothiazepine-2(3H)-one;7-Chloro-5-(2-chlorophenyl)-1;CGP 37157, Na+-Ca2+ exchange inhibitor;CGP-37157 - CAS 75450-34-9 - Calbiochem;CGP 37157,CGP37157,Inhibitor,CGP-37157,inhibit,Na+/Ca2+ Exchanger;7-chloro-5-(2-chlorophenyl)benzo[e][1,4]thiazepin-2(1H,3H,5H)-one
CBNumber
CB7314153
Molecular Formula
C15H11Cl2NOS
Formula Weight
324.22
MOL File
75450-34-9.mol
More
Less

7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE Property

Boiling point:
479.8±45.0 °C(Predicted)
Density 
1.384±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥20mg/mL
form 
White solid
pka
12.20±0.40(Predicted)
color 
white
Stability:
Stable for 2 years from date of purchase as supplied. Solution in DMSO may be stored at -20°C for up to 3 months.
More
Less

Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50
Safety Statements 
61
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C8874
Product name
CGP-37157
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$162.45
Updated
2025/07/31
Sigma-Aldrich
Product number
220005
Product name
CGP-37157
Packaging
5mg
Price
$230
Updated
2024/03/01
TCI Chemical
Product number
C3956
Product name
CGP 37157
Packaging
5MG
Price
$152
Updated
2025/07/31
TCI Chemical
Product number
C3956
Product name
CGP 37157
Packaging
25MG
Price
$456
Updated
2025/07/31
Cayman Chemical
Product number
15611
Product name
CGP 37157
Purity
≥99%
Packaging
10mg
Price
$144
Updated
2024/03/01
More
Less

7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE Chemical Properties,Usage,Production

Description

CGP-37157 (75450-34-9) inhibits?the mitochondrial Na+-Ca2+?exchanger (NCX) in isolated heart mitochondria, IC50=0.36 μM.1?Does not inhibit the plasmalemmal NCX.2? Also inhibits voltage-gated Ca2+?channels in intact cells and therefore its use in cellular studies must employ adequate controls.3? Prevents sudden death in a Guinea pig model of heart failure.4?Displays pronounced cytoprotective effects in chromaffin cells5?and in neuronal injury models.6?Blood-brain barrier permeant.

Uses

7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one is a specific inhibitor of the mitochondrial Na+/Ca2+ exchanger.

Uses

CGP-37157 has been used as a mitochondrial sodium-calcium exchanger (mNCX) inhibitor to study the role of normal mitochondrial calcium dynamics in sustaining dendritic spinogenesis.

Definition

ChEBI: 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2-one is a benzothiazepine.

General Description

CGP-37157 is a benzothiazepine compound, which is derived from clonazepam. It functions as a sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) antagonist and ryanodine receptor channels (RyR) agonist. CGP-37157 regulates intracellular signaling of calcium in smooth, cardiac and skeletal muscle cells and non-muscle systems.

Biological Activity

Selective antagonist of the mitochondrial Na + -Ca 2+ exchanger (IC 50 = 0.4 μ M).

Biochem/physiol Actions

Specific inhibitor of mitochondrial Na+/Ca2+ exchange as well as sarcoplasmic reticulum calcium-stimulated ATPase and possibly other calcium channels.

storage

Room temperature

References

[1] D A COX. Selectivity of inhibition of Na(+)-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157.[J]. Journal of Cardiovascular Pharmacology, 1993, 21 4: 595-599. DOI:10.1097/00005344-199304000-00013
[2] IYUKI NAMEKATA  Hikaru T  Shogo Hamaguchi. Pharmacological discrimination of plasmalemmal and mitochondrial sodium-calcium exchanger in cardiomyocyte-derived H9c2 cells.[J]. Biological & pharmaceutical bulletin, 2015, 38 1: 147-150. DOI:10.1248/bpb.b14-00525
[3] KYLE T BARON  Stanley A T. CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root ganglion neurons[J]. European journal of pharmacology, 1997, 340 2: Pages 295-300. DOI:10.1016/s0014-2999(97)01433-7
[4] TING LIU. Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a Guinea pig model of heart failure.[J]. Circulation research, 2014, 115 1: 44-54. DOI:10.1161/circresaha.115.303062
[5] SANTOS M NICOLAU. Mitochondrial Na+/Ca2+-exchanger blocker CGP37157 protects against chromaffin cell death elicited by veratridine.[J]. Journal of Pharmacology and Experimental Therapeutics, 2009, 330 3: 844-854. DOI:10.1124/jpet.109.154765
[6] A RUIZ  C M  E Alberdi. CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels[J]. Cell Death & Disease, 2014, 5 4: e1156-e1156. DOI:10.1038/cddis.2014.134

7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE Suppliers

China 78 Germany 2 India 1 United Kingdom 6 United States 14 Global 101
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Focus Biomolecules
Tel
--
Fax
--
Email
sales@focusbiomolecules.com
Country
United States
ProdList
1284
Advantage
58
Abcam Limited
Tel
--
Fax
--
Email
us.orders@abcam.com
Country
United States
ProdList
6001
Advantage
50
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
EMD Biosciences, Inc.
Tel
--
Fax
--
Email
technical@calbiochem.com
Country
United States
ProdList
6529
Advantage
66
BIOMOL INTERNATIONAL, LP
Tel
--
Fax
--
Email
info@biomol.com
Country
United States
ProdList
1499
Advantage
77

75450-34-9, 7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONERelated Search:

POLYGODIAL Dofetilide 3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone Melatonine BONGKREKIC ACID Probenecid FCCP Mirin VERATRIDINE COENZYME Q2 CITRININ BA, 3NH4 CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE DECYLUBIQUINONE (S)-PBMC (PBMC) 2-[(Diphenylmethyl)thio]acetamide 7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE

  • 7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE
  • CGP 37157
  • 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one
  • 4,1-Benzothiazepin-2(3H)-one, 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-
  • 7-chloro-5-(2-chlorophenyl)benzo[e][1,4]thiazepin-2(1H,3H,5H)-one
  • CGP-37157 - CAS 75450-34-9 - Calbiochem
  • 1-benzothiazepine-2(3H)-one
  • 7-Chloro-5-(2-chlorophenyl)-1
  • 7-Chloro-5-(2-chlorophenyl)-3,5-dihydrobenzo[e][1,4]thiazepin-2(1H)-one
  • CGP 37157,CGP37157,Inhibitor,CGP-37157,inhibit,Na+/Ca2+ Exchanger
  • 7-Chloro-5-(2-chlorophenyl)-1,5-dihydrobenzo[e][1,4]thiazepin-2(3H)-one
  • CGP 37157, Na+-Ca2+ exchange inhibitor
  • CGP37157, 10 mM in DMSO
  • CGP
  • CGP-37157 ，E0002
  • 75450-34-9
  • C15H12ClNOS
  • Ion transporter and other ion channel
  • Signalling