Talniflumate
- Product Name
- Talniflumate
- CAS No.
- 66898-62-2
- Chemical Name
- Talniflumate
- Synonyms
- somalgen;ba7602-06;TALNIFLUMATE;Talniflumate, >=99%;Talniflumate (BA 7602-06);TALNIFLUMATE(INTERMEDIATE);phthalidyl2-(3-trifluoromethylanilino)nicotinate;2-(α,α,α-Trifluoro-m-toluidino)nicotinic acid phthalidyl ester;phthalidyl2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinate;2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinicacidphthalidylester
- CBNumber
- CB7315594
- Molecular Formula
- C21H13F3N2O4
- Formula Weight
- 414.33
- MOL File
- 66898-62-2.mol
Talniflumate Property
- Melting point:
- 165-167°C
- Boiling point:
- 534.6±50.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- Chlorform (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 2.72±0.10(Predicted)
- form
- Solid
- color
- Off-White to Pale Yellow
- λmax
- 287nm(CHCl3)(lit.)
- Merck
- 14,9044
- Stability:
- Acid Sensitive, Moisture Sensitive
Safety
- RTECS
- QT2999200
- HS Code
- 2933.39.9200
- Toxicity
- LD50 orally in rats: 12000 mg/kg (Los)
N-Bromosuccinimide Price
- Product number
- SML1710
- Product name
- Talniflumate
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $86
- Updated
- 2024/03/01
- Product number
- SML1710
- Product name
- Talniflumate
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $350
- Updated
- 2024/03/01
- Product number
- T3101
- Product name
- Talniflumate
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 1g
- Price
- $327
- Updated
- 2024/03/01
- Product number
- T3101
- Product name
- Talniflumate
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 200mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 29623
- Product name
- Talniflumate
- Packaging
- 5mg
- Price
- $38
- Updated
- 2024/03/01
Talniflumate Chemical Properties,Usage,Production
Chemical Properties
White to pale yellow crystalline powder
Originator
Somalgen,Bago,Argentina,1972
Uses
Talniflumate is a nonaspirin and nonsteroidal anti-inflammatory drug.
Uses
Anti-inflammatory; analgesic.
Definition
ChEBI: 2-[3-(trifluoromethyl)anilino]-3-pyridinecarboxylic acid (3-oxo-1H-isobenzofuran-1-yl) ester is a member of benzofurans.
Manufacturing Process
49 ml of triethylamine were added to a suspension of 2-(3'-
trifluoromethylanilino)nicotinic acid (70.6 g in 250 ml of dimethylformamide).
After stirring for 30 minutes 53.3 g of 3-bromophthalide were added. The
reaction mixture was maintained at 25°C to 30°C during 4 hours. Ethyl
acetate (750 ml) was poured into the reaction mixture. This solution was
filtered and extracted with water (4 x 250 ml), discarding the water layer.
The organic layer was dried with anhydrous magnesium sulfate and then
filtered. The solution was concentrated under vacuum at 30°C to 35°C until
reduced to half of its original volume and then cooled to 5°C to allow the
crystallization of the compound. Thus, the cake was filtered, washed with cool
ethyl acetate, and dried under vacuum. Yield: 74% (76.7 g) of phthalidyl
ester of 2-(3'-trifluoromethylanilino)-pyridin-3-carboxylic acid, melting point:
165°C to 167°C.
brand name
Somalgen (Laboratorio Bago, S.A., Argentina).
Therapeutic Function
Antiinflammatory, Analgesic
Biological Activity
Calcium-activated chloride channel (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release in cell culture and animal models. Possesses anti-inflammatory actions via inhibition of cyclooxygenases and inhibits Cl - /HCO 3 - exchanger activity. Increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.
Talniflumate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Talniflumate manufacturers
- Product
- (3-oxo-1H-2-benzofuran-1-yl) 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylate 66898-62-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons/month
- Release date
- 2020-01-09