Talniflumate

ChemicalBook > CAS DataBase List > Talniflumate

Product Name: Talniflumate
CAS No.: 66898-62-2
Chemical Name: Talniflumate
Synonyms: somalgen;ba7602-06;TALNIFLUMATE;Talniflumate, >=99%;Talniflumate (BA 7602-06);TALNIFLUMATE(INTERMEDIATE);phthalidyl2-(3-trifluoromethylanilino)nicotinate;2-(α,α,α-Trifluoro-m-toluidino)nicotinic acid phthalidyl ester;phthalidyl2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinate;2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinicacidphthalidylester
CBNumber: CB7315594
Molecular Formula: C21H13F3N2O4
Formula Weight: 414.33
MOL File: 66898-62-2.mol

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Talniflumate Property

Melting point:: 165-167°C
Boiling point:: 534.6±50.0 °C(Predicted)
Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: Chlorform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 2.72±0.10(Predicted)
form: Solid
color: Off-White to Pale Yellow
λmax: 287nm(CHCl3)(lit.)
Merck: 14,9044
Stability:: Acid Sensitive, Moisture Sensitive

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Safety

RTECS: QT2999200
HS Code: 2933.39.9200
Toxicity: LD50 orally in rats: 12000 mg/kg (Los)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1710
Product name: Talniflumate
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $86
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1710
Product name: Talniflumate
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $350
Updated: 2024/03/01

TCI Chemical

Product number: T3101
Product name: Talniflumate
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $327
Updated: 2024/03/01

TCI Chemical

Product number: T3101
Product name: Talniflumate
Purity: >98.0%(HPLC)(N)
Packaging: 200mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 29623
Product name: Talniflumate
Packaging: 5mg
Price: $38
Updated: 2024/03/01

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Talniflumate Chemical Properties,Usage,Production

Chemical Properties

White to pale yellow crystalline powder

Originator

Somalgen,Bago,Argentina,1972

Uses

Talniflumate is a nonaspirin and nonsteroidal anti-inflammatory drug.

Uses

Anti-inflammatory; analgesic.

Definition

ChEBI: 2-[3-(trifluoromethyl)anilino]-3-pyridinecarboxylic acid (3-oxo-1H-isobenzofuran-1-yl) ester is a member of benzofurans.

Manufacturing Process

49 ml of triethylamine were added to a suspension of 2-(3'- trifluoromethylanilino)nicotinic acid (70.6 g in 250 ml of dimethylformamide). After stirring for 30 minutes 53.3 g of 3-bromophthalide were added. The reaction mixture was maintained at 25°C to 30°C during 4 hours. Ethyl acetate (750 ml) was poured into the reaction mixture. This solution was filtered and extracted with water (4 x 250 ml), discarding the water layer.
The organic layer was dried with anhydrous magnesium sulfate and then filtered. The solution was concentrated under vacuum at 30°C to 35°C until reduced to half of its original volume and then cooled to 5°C to allow the crystallization of the compound. Thus, the cake was filtered, washed with cool ethyl acetate, and dried under vacuum. Yield: 74% (76.7 g) of phthalidyl ester of 2-(3'-trifluoromethylanilino)-pyridin-3-carboxylic acid, melting point: 165°C to 167°C.

brand name

Somalgen (Laboratorio Bago, S.A., Argentina).

Therapeutic Function

Antiinflammatory, Analgesic

Biological Activity

Calcium-activated chloride channel (hCLCA1/mCLCA3) blocker; reduces mucin synthesis and release in cell culture and animal models. Possesses anti-inflammatory actions via inhibition of cyclooxygenases and inhibits Cl - /HCO 3 - exchanger activity. Increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.

Talniflumate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Talniflumate manufacturers

Career Henan Chemical Co

Product: (3-oxo-1H-2-benzofuran-1-yl) 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylate 66898-62-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons/month
Release date: 2020-01-09

66898-62-2, TalniflumateRelated Search:

4-Dimethylaminopyridine Tris(hydroxymethyl)aminomethane Dihydromyrcenol Cyhalofop-butyl 2,5-PYRIDINEDICARBOXYLIC ACID Glycine 3-Aminopyridine FLURBIPROFEN AXETIL Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Quinolinic acid ALTRENOGEST 2-Aminopyridine PHENYL VALERATE 2-(Methylamino)pyridine-3-methanol Niflumic acid 2-(Methylamino)pyridine-3-carboxylic acid Benzyl nicotinate Phenylacetic acid

2-(alpha,alpha,alpha-trifluoro-m-toluidino)-nicotinicaciphthalidylester

3-ftalidilicodelacido2-((3-(trifluormetil)fenil)amino)-3-piridincarboxilic

3-phthalidylesterof2-((3-(trifluoromethyl)phenyl)amino)-3-pyridinecarboxyl

Talniflumate, >=99%

2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinicacidphthalidylester

2-[3-(trifluoromethyl)anilino]-3-pyridinecarboxylic acid (3-oxo-1H-isobenzofuran-1-yl) ester

(3-oxo-1H-2-benzofuran-1-yl) 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylate

ba7602-06

phthalidyl2-(3-trifluoromethylanilino)nicotinate

phthalidyl2-(alpha,alpha,alpha-trifluoro-m-toluidino)nicotinate

somalgen

2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO]-3-PYRIDINECARBOXYLIC ACID 1,3-DIHYDRO-3-OXO-1-ISOBENZOFURANYL ESTER

3-pyridinecarboxylic acid 2-{[(3-trifluoromethyl)phenyl]amino}-1,3-dihydro-3-oxo-1-soenzofuranyl ester

TALNIFLUMATE

TALNIFLUMATE(INTERMEDIATE)

2-(α,α,α-Trifluoro-m-toluidino)nicotinic acid phthalidyl ester

2-[[3-(Trifluoromethyl)phenyl]amino]nicotinic acid 1,3-dihydro-3-oxoisobenzofuran-1-yl ester

2-[[3-(Trifluoromethyl)phenyl]amino]-1,3-dihydro-3-oxo-1-isobenzofuranyl3-pyridinecarboxylicacidester

3-Pyridinecarboxylic acid, 2-[[3-(trifluoromethyl)phenyl]amino]-, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester

Talniflumate (BA 7602-06)

3-Oxo-1,3-dihydroisobenzofuran-1-yl 2-((3-(trifluoromethyl)phenyl)amino)nicotinate

66898-62-2

66898-62

C21H13F3N2O4